Effects of SCH 23390 and sulpiride on the behaviors evoked by amphetamine and apomorphine in adult cats

Motles, E; Gómez, Ariel; Tetas, Montserrat; Gonzalez, Magali

doi:10.1016/0278-5846(93)90027-p

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…With the higher dose, the pigeons showed signs of marked sedation. Dopamine antagonists generally, and SCH-23390 particularly, are known to induce sedation at higher doses (Lublin, Gerlach, & Peacock, 1993;Motles, Gomez, Tetas, & Gonzales, 1993). In a preliminary experiment we used 3 pigeons with on-target injection sites (see Figure 1) that were food de-prived to 80% of their normal body weight.…”

Section: Drugsmentioning

confidence: 99%

Behavioral Sensitization to Apomorphine in Pigeons (Columba livia): Blockade by the D₁ Dopamine Antagonist SCH-23390.

Acerbo¹,

Delius²

2004

Behavioral Neuroscience

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Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SCH-23390 on both the sensitized response and the CR. When coadministered with apomorphine, SCH-23390 inhibited the initial response to apomorphine, prevented the development of sensitization, and impaired the maintenance of an already developed sensitization. However, SCH-23390 had no effect on the retrieval of a previously established CR. It is concluded that the activation of D(1) receptors in the caudal avian striatum is necessary for the acquisition and maintenance of the sensitization, but not for the expression, of the CR.

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Section: Drugsmentioning

confidence: 99%

Behavioral Sensitization to Apomorphine in Pigeons (Columba livia): Blockade by the D₁ Dopamine Antagonist SCH-23390.

Acerbo¹,

Delius²

2004

Behavioral Neuroscience

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“…in a volume of 1 μl/site. Because dopamine antagonists, and SCH23390 particularly, can induce sedation and motor impairments at higher doses (Lublin et al, 1993;Motles et al, 1993), we gave both drugs at 3 μg/μl, in a dose previously found to block behavioral sensitization by i.c. apomorphine without causing motor or motivational defects (Acerbo and Delius, 2004).…”

Section: Drug Preparation and Ic Administrationmentioning

confidence: 99%

Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks

Xiao

Song

2010

European Journal of Pharmacology

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In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various behavioral paradigms, such as one-trial passive avoidance learning. However, it is not yet clear whether the dopaminergic system of these regions is responsible for associative learning underlying cue-elicited drug reward. In this study, a 6-day conditioning schedule in day-old chicks with i.p. morphine (2 mg/kg) was used to compare the effects of intracerebrally injected dopamine D(1) receptor antagonist, SCH23390, and D(2) antagonist, spiperone. The antagonists were injected bilaterally (3 microg/site) into either the medial striatum or the intermediate medial mesopallium, and tests were conducted on morphine-induced conditioned place preference or locomotor activity. The acquisition of place preference was significantly inhibited by SCH23390 in either the medial striatum or the intermediate medial mesopallium, but not by spiperone. However, in the medial striatum, but not in the intermediate medial mesopallium, the locomotor activity was blocked by both SCH23390 and spiperone. These data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine D(1) system may play an important role in the development of opiate reward.

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Behavioral effects evoked by SKF 38393 and LY 171555 in adult cats

Motles

Tetas

Gómez

1995

Physiology & Behavior

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Effects of SCH 23390 and sulpiride on the behaviors evoked by amphetamine and apomorphine in adult cats

Cited by 6 publications

References 23 publications

Behavioral Sensitization to Apomorphine in Pigeons (Columba livia): Blockade by the D₁ Dopamine Antagonist SCH-23390.

Behavioral Sensitization to Apomorphine in Pigeons (Columba livia): Blockade by the D₁ Dopamine Antagonist SCH-23390.

Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks

Behavioral effects evoked by SKF 38393 and LY 171555 in adult cats

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