Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert

Aigner, Thomas; Mitchell, S. J.; Aggleton, John Patrick; DeLong, Mahlon R.; Struble, Robert G.; Price, Donald L.; Wenk, Gary L.; Mishkin, Mortimer

doi:10.1007/bf00210833

Cited by 106 publications

(25 citation statements)

References 42 publications

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“…Cholinergic agonists, cholinesterase inhibitors, and hippocampal grafts of cholinergic neurons have been reported to restore memory function after these lesions and to improve memory function in normal rats and mice (26)(27)(28)(29)(30). Our findings demonstrate that ACh infusion ivt or intrahippocampally can ameliorate a NBM-MSA lesioninduced memory deficit for a short period oftime and that this treatment can be effectively repeated in the same animal.…”

Section: Methodssupporting

confidence: 52%

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

Mastropaolo

Nadi

Ostrowski

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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Galanin coexists with acetylcholine in medial septal neurons projecting to the ventral hippocampus, a projection thought to modulate memory functions. Neurochemical lesions of the nucleus basalis-medial septal area in rats impaired choice accuracy on a delayed alternation t-maze task. Acetylcholine (7.5 or 10 ,sg intraventricularly or 1 ,.g microinjected into the ventral hippocampus) significantly improved performance in the lesioned rats. Atropine (5 mg/kg intraperitoneally or 10 ,.g intraventricularly), but not mecamylamine (3 mg/kg intraperitoneally or 20 ,ug intraventricularly), blocked this action of acetylcholine, suggesting involvement of a muscarinic receptor. Galanin (100-500 ng intraventricularly or 200 ng into the ventral hippocampus) attenuated the ability of acetylcholine to reverse the deficit in working memory in the lesioned rats. The antagonistic interaction between galanin and acetylcholine suggests that endogenous galanin may inhibit cholinergic function in memory processes, particularly in pathologies such as Alzheimer disease that involve degeneration of basal forebrain neurons.Galanin (GAL) is a 29-amino acid peptide (1) localized in many regions of the mammalian central nervous system (2-5). Immunohistochemical studies revealed the coexistence of GAL and choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), in the medial septal nucleus and nucleus basalis/diagonal band complex of primates (6, 7).In the rat, GAL coexists with ACh in the medial septal neurons projecting to the ventral hippocampus but not in the nucleus basalis neurons projecting to the cerebral cortex (8, 9). The localization of this peptide in the septo-hippocampal pathway, and the high density of GAL binding sites labeled with 1251I-labeled GAL in the ventral hippocampus (10), raise the possibility of a functional role for GAL in memory processes. To investigate the functional significance of the GAL-ACh coexistence, rats were microinjected with GAL, ACh, GAL plus ACh, or saline before behavioral testing with a t-maze delayed alternation task, in which performance was disrupted by lesions of the nucleus basalis-medial septal area (11). MATERIALS AND METHODSMale Sprague-Dawley rats, 200 g (starting weight), were housed in a temperature and humidity controlled vivarium, with lights on from 0700 to 1900. Lesions of the nucleus basalis magnocellularis (NBM) and medial septal area (MSA) were performed according to the methods of Wenk and coworkers (12). Briefly, rats were anesthetized with sodium pentobarbital (50 mg/kg, i.p.) and intracerebrally microinjected through 31-gauge hypodermic tubing with ibotenic acid (in isotonic phosphate-buffered saline, pH 7.7, shielded from light; Sigma), at five individual stereotaxic sites: 1.3 and 1.7 mm posterior to bregma, bilaterally 2.6 mm lateral to the midline, and 7.5 mm ventral to the surface of the skull with 4 ,ug in 0.4 ,ul over 2.5 min for NBM, and 0.8 mm anterior to bregma, at the midline, and 6.5 mm ventral to the surface of the skull with 6 ,u...

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Section: Methodssupporting

confidence: 52%

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

Mastropaolo

Nadi

Ostrowski

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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“…More specifically, prefrontal ACh has been implicated in working memory processes as demonstrated by behavioral tasks including delayed nonmatching to sample (Broersen et al, 1995) and object recognition tests (Aigner et al, 1987;Giovannini et al, 1998;Scali et al, 1994). Furthermore, cognitive-enhancing drugs can increase ACh release in the prefrontal cortex (Scali et al, 1994;Yamamoto et al, 1994) whereas direct application of the muscarinic cholinergic receptor antagonist scopolamine into the frontal cortex (Mouton et al, 1988) or the hippocampus (Messer et al, 1991) impairs working memory.…”

Section: A Potential Role Of Da D 3 Receptors In the Effect Of Apds Omentioning

confidence: 99%

Selective Antagonism at Dopamine D3 Receptors Enhances Monoaminergic and Cholinergic Neurotransmission in the Rat Anterior Cingulate Cortex

Lacroix

Hows

Shah

et al. 2002

Neuropsychopharmacol

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Recent neuroanatomical and functional investigations focusing on dopamine (DA) D 3 receptors have suggested a potential role of this receptor in psychiatric diseases such as schizophrenia and drug dependence. In line with the key role of the prefrontal cortex in psychiatric disorders, the present study aimed at assessing the effects of the acute systemic administration of the selective DA D 3 receptor antagonist SB-277011-A on the in vivo extracellular levels of monoamines (DA, norepinephrine (NE), and serotonin (5-HT)) and acetylcholine (ACh) in the anterior cingulate subregion of the medial prefrontal cortex. The in vivo neurochemical profile of SB-277011-A (10 mg/kg, i.p.) in the anterior cingulate cortex was compared with both typical and atypical antipsychotics including clozapine (10 mg/kg, s.c.), olanzapine (10 mg/kg, s.c.), sulpiride (10 mg/kg, s.c.), and haloperidol (0.5 mg/kg, s.c.). The acute administration of SB-277011-A, clozapine, and olanzapine produced a significant increase in extracellular levels of DA, NE, and ACh without affecting levels of 5-HT. Sulpiride also significantly increased extracellular DA, but with a delayed onset over SB-277011-A, clozapine, and olanzapine. In contrast, haloperidol failed to alter any of the three monoamines and ACh in the anterior cingulate cortex. These findings add to a growing body of evidence suggesting a differentiation between typical and atypical antipsychotic drugs (APDs) in the anterior cingulate cortex and a role of DA D 3 receptors in desired antipsychotic drug profile. Similar to their effects on DA and NE, SB-277011-A, clozapine, and olanzapine increased extracellular levels of ACh, whereas haloperidol and sulpiride did not alter ACh. The results obtained in the present study provide evidence of the important role of DA D 3 receptors in the effect of pharmacotherapeutic agents that are used for the treatment of psychiatric disorders such as schizophrenia and drug dependence.

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“…At doses higher than those proposed for incorporation in pretreatment regimens, scopolamine has been shown to affect performance on a range of cognitive tasks in rhesus monkeys (Aigner et al 1987;Taffe et al1999), and Ridley et al (1984) showed that administration of scopolamine resulted in both impaired acquisition of object-reward associations and impairments in transfer of that association to long-term memory in marmosets. Such object discrimination impairments in marmosets have been shown to be reversible by cholinergic agonists, such as arecoline (Carey et al 1992).…”

Section: Introductionmentioning

confidence: 97%

Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus)

et al. 2003

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Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert

Cited by 106 publications

References 42 publications

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.

Selective Antagonism at Dopamine D3 Receptors Enhances Monoaminergic and Cholinergic Neurotransmission in the Rat Anterior Cingulate Cortex

Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus)

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