Effects of <scp>l</scp>-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis

Li, Yanfei; Xie, Yuchen; Qiu, Chensheng; Yu, Bowen; Yang, Fangzheng; Cheng, Yuanchao; Zhong, Weizhen; Yuan, Junhua

doi:10.1039/d2fo02930h

Food Funct.

2023

DOI: 10.1039/d2fo02930h

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Effects of l-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis

Yanfei Li

Yuchen Xie

Chensheng Qiu

et al.

Abstract: Background: L-carnitine supplementation has been utilized against glucolipid metabolism disruption. However, to the best of our knowledge, no meta-analysis had analyzed the effects of L-carnitine supplementation on insulin resistance, fasting...

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2024

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Cited by 2 publications

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Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs

Karimi,

Pirzad,

Pourfaraji

et al. 2024

Front. Med.

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BackgroundChronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality. This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients.MethodsA comprehensive search was conducted across the online databases from inception to June 2024 to identify randomized clinical trials (RCTs) evaluating the effects of L-carnitine on lipid profiles in hemodialysis patients. Data extraction and quality assessment were performed, focusing on primary outcomes, including changes in triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), and secondary outcomes including blood pressure (BP) and body mass index (BMI).ResultsA total of 28 RCTs were eligible for the current systematic review, including 1,340 hemodialysis patients (671 intervention, 669 control). There were no significant differences in the mean change of TG (SMD: −0.006; 95% CI, −0.272 to 0.259; P = 0.95), TC (SMD: −0.086; 95% CI, −0.253 to −0.079; P = 0.29), HDL (SMD: 0.060; 95% CI, −0.057 to 0.177; P = 0.29), LDL (SMD: −0.075; 95% CI, −0.274 to 0.123; P = 0.43), VLDL (SMD: −0.064; 95% CI, −0.272 to 0.142; P = 0.51), BMI (SMD: −0.025; 95% CI, −0.139 to 0.088; P = 0.56), systolic BP (SMD: 0.055; 95% CI, −0.110 to 0.220; P = 0.43), and diastolic BP (SMD: −0.028; 95% CI, 0.156 to 0.099; P = 0.56). The same insignificant findings were observed after conducting a subgroup analysis based on the route of administration (intravenous vs. Oral).ConclusionL-carnitine supplementation does not significantly change and improve the serum lipid profile, including TG, TC, HDL, LDL, and VLDL levels. Additionally, it has no notable effects on BMI, systolic, or diastolic BP.

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Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs

Karimi,

Pirzad,

Pourfaraji

et al. 2024

Front. Med.

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Evaluation of the effect of the antioxidant complex “BESTFertil-DHA” on spermogram parameters and the index of sperm DNA fragmentation in men from infertile couples with metabolic syndrome

Gamidov,

Popova,

Shatylko

et al. 2024

Androl. genit. hir.

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Introduction. Antioxidant therapy is the optimal type of treatment for idiopathic male infertility due to the good ratio of efficacy and safety. Considering that oxidative stress is one of the pathogenetic links in sperm DNA damage, antioxidant drugs can also reduce the DNA fragmentation index. Men who are overweight or severely obese have a high risk of sexual dysfunction and reproductive disorders. Antioxidant therapy plays a leading role in infertility associated with metabolic syndrome. The main active ingredients in «BESTFertil-DHA» are L-carnitine, eicosapentaenoic and docosahexaenoic acids, the action of which is complemented by other components, which makes the use of the complex attractive in combination with male infertility and metabolic syndrome. However, it is unknown how well they work with a combination of these pathological conditions. Aim. Is to evaluate the effectiveness of administration of Russian complex «BESTFertil-DHA» on spermogram parameters and the index of sperm DNA fragmentation in men from infertile couples with metabolic syndrome. Materials and methods. The study included 60 patients divided into cohort A- 26 patients with metabolic syndrome, cohort B- 34 patients without metabolic syndrome. All patients received «BESTFertil-DHA». All patients underwent a spermogram, an analysis for the fermentation of sperm DNA, blood for sex hormones, markers of metabolic syndrome on the first visit, and on the 2nd visit after therapy. Results. In cohort A, significant results were observed in terms of weight, BMI, C-reactive protein level, and HOMA-IR index. There is a significant improvement in the parameters of the spermogram, a decrease in the index of fragmentation of sperm DNA, a decrease in estradiol, normalization of the T/E2 index. In cohort B, changes in weight, BMI and a number of spermological parameters were observed, there were no changes in metabolic and endocrine parameters. Conclusion. Combined antioxidant therapy in the form of a complex of nutrients «BESTFertil-DHA» effectively reduces the index of fragmentation of sperm DNA and leads to normalization of spermogram parameters, both in the general cohort of patients and among men with metabolic syndrome. Moreover, in the latter, the «BESTFertilDHA» complex in combination with measures to reduce body weight gives additional therapeutic effects, affecting carbohydrate metabolism, aromatization of testosterone and the severity of systemic inflammation

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Effects of l-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis

Abstract: Background: L-carnitine supplementation has been utilized against glucolipid metabolism disruption. However, to the best of our knowledge, no meta-analysis had analyzed the effects of L-carnitine supplementation on insulin resistance, fasting...

Cited by 2 publications

References 55 publications

Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs

Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs

Evaluation of the effect of the antioxidant complex “BESTFertil-DHA” on spermogram parameters and the index of sperm DNA fragmentation in men from infertile couples with metabolic syndrome

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