Effects of <scp>l</scp>-lactide and <scp>d</scp>,<scp>l</scp>-lactide in poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) on the bulk states of triblock copolymers, and their thermogellation and biodegradation in water

Chen, Chang; Lin, Chen; Cao, Liqin; Shen, Wen; Yu, Lin; Ding, Jiandong

doi:10.1039/c3ra47494a

Cited by 30 publications

(27 citation statements)

References 65 publications

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“…40 Chen et al in a similar study to Yu et al synthesised ABA copolymers but the composition of the A block was varied which was based on GA and L-lactide (LLA) while the B block was based on EO. 49 However the T gel increased upon increasing the LLA/GA ratio while the CGC remained at similar values. 49 This contradictory result regarding the T gel was probably due to the significant influence of the stereochemistry that counteracted the hydrophobic content effect as will be discussed later on.…”

Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 94%

“…49 However the T gel increased upon increasing the LLA/GA ratio while the CGC remained at similar values. 49 This contradictory result regarding the T gel was probably due to the significant influence of the stereochemistry that counteracted the hydrophobic content effect as will be discussed later on. In another study on ABA triblock copolymers where the A blocks were based on both caprolactone (CL) and GA, of different ratios, whereas the B block consisted, as in the previous study, 48 of EO.…”

Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 94%

“…57 Two studies on ABA triblocks were reported. 49,58 In the first study, two series of polymers were investigated where the B block was kept constant; EO based, while the A block was varied by being based either on GA and LLA or GA and DLLA. 49 The copolymers of each series possessed different compositions; discussed previously.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

“…49,58 In the first study, two series of polymers were investigated where the B block was kept constant; EO based, while the A block was varied by being based either on GA and LLA or GA and DLLA. 49 The copolymers of each series possessed different compositions; discussed previously. For the polymers with higher lactide (LA)/GA ratio, the T gel of the DLLA based copolymer was lower than that of the LLA based one; determined after visual tests.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

“…49 In the second study ABA triblocks copolymers with A and B based on LLA or DLLA and EO, respectively, were studied by visual and rheological tests. 58 According to visual tests, above a certain concentration, the LLA and DLLA based copolymers did and did not gel, respectively.…”

Section: Effect Of Stereochemistrymentioning

confidence: 99%

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Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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Thermoresponsive gels are exciting polymeric materials with many biomedical applications in medical devices, drug delivery, tissue engineering and bio-printing. Also, they have great potential to be used in 3-D printing and thus in the fabrication of many different devices and materials. As it is crucial for the application of these gels to be able to control and tailor the gelation temperature and concentration this was the main focus and point of discussion of this feature article. Thus, it is discussed in detail how by varying the molar mass, composition, stereochemistry and architecture the thermoresponsive properties of these gels are altered.

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Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 94%

Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 94%

Section: Effect Of Stereochemistrymentioning

confidence: 99%

Section: Effect Of Stereochemistrymentioning

confidence: 99%

Section: Effect Of Stereochemistrymentioning

confidence: 99%

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Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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Thermoresponsive Multiblock Copolymers: Chemistry, Properties and Applications

Constantinou

Georgiou

2018

Temperature‐Responsive Polymers

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Amphiphilic polylactide‐poly(ethylene oxide)‐poly(propylene oxide) block copolymers: Self‐assembly behavior and cell affinity

Loiola

Farias

Portugal

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Polylactide (PLA) is a biodegradable polyester recognized for its potential use as a biomedical material. Poly(ethylene oxide) (PEO) and copolymers based on PEO and poly(propylene oxide) (PPO) are biocompatible polyethers widely applied in the biomedical field, particularly as macromolecular nonionic surfactants. In this work, PLA blocks were attached to the PEO and to the PEO and PPO‐based triblock copolymer PEO–PPO–PEO, through ring‐opening polymerization of racemic lactide (rac‐LA) to obtain the amphiphilic triblock PLA–PEO–PLA and pentablock PLA–PEO–PPO–PEO–PLA copolymers containing hydrophilic/hydrophobic blocks with variable block mass ratios. The copolymers were evaluated for chemical composition, molar mass, and thermal properties, and they were used to prepare self‐assemble aggregates in water from tetrahydrofuran polymer solutions. The combination of scattering light experiments and microscopy techniques revealed the spherical morphology of the aggregates with diameters around 180–200 nm, which comprises a hydrophobic PLA core and a hydrophilic polyether shell. The aggregates are nontoxic to human cervical cancer cell line — HeLa cells, as determined by MTS assay, and the aggregates are potential candidates to be applied in the encapsulation of hydrophobic compounds. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2203–2213

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Effects of l-lactide and d,l-lactide in poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) on the bulk states of triblock copolymers, and their thermogellation and biodegradation in water

Abstract: In this study, the effects of l-lactide and d,l-lactide on the thermogelling and biodegradation behaviors of PLGA-PEG-PLGA copolymers were revealed.

Cited by 30 publications

References 65 publications

Tuning the gelation of thermoresponsive gels

Tuning the gelation of thermoresponsive gels

Thermoresponsive Multiblock Copolymers: Chemistry, Properties and Applications

Amphiphilic polylactide‐poly(ethylene oxide)‐poly(propylene oxide) block copolymers: Self‐assembly behavior and cell affinity

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