Effects of sea buckthorn (Hippophae rhamnoides L.) on factors related to metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trial

Abstract

The purpose of this meta‐analysis is to explore whether the supplement of sea buckthorn affects the factors related to metabolic syndrome. The related RCTs from five databases were systematically searched and comprehensively random effects model was used to calculate SMD and 95% CI. The Cochrane deviation risk tool was used to evaluate the deviation risk. Fifteen studies were involved in the meta‐analysis. First, sea buckthorn supplementation reduced triglycerides [−0.722 (−1.129, −0.316); p < .001], total cholesterol [−0.345 (−0.639, −0.051); p = .021], low density lipoprotein cholesterol [−0.396 (−0.755, −0.037); p = .031], and increased high density lipoprotein cholesterol [0.370 (0.056, 0.684); p = .021] in overall subjects. Second, subgroup analysis showed that sea buckthorn supplementation reduced lipids only in people with abnormal lipid metabolism. Third, sea buckthorn had no effect on blood sugar, blood pressure, and BMI of the overall subjects. Sea buckthorn may affect the lipid metabolism in circulation, but it cannot affect blood glucose, blood pressure, and BMI. These indicators are closely associated with metabolic syndrome. This study may contribute to the development and utilization of sea buckthorn, and may provide a new and safer way for the prevention and treatment of metabolic syndrome. The limitation of this study is high heterogeneity, even if subgroup analysis is used. However, more clinical studies are needed to determine the real effect of sea buckthorn on metabolic syndrome.

The effects of medicinal and food homologous substances on blood lipid and blood glucose levels and liver function in patients with nonalcoholic fatty liver disease: a systematic review of randomized controlled trials

“…Currently, there is a growing trend of systematic evaluations being conducted on medicinal and food homologous substances both domestically and internationally [ 31 – 33 ]. However, they are all focused on a single substance and have not been discussed and analyzed from the category of medicinal and food homologous substances.…”

“…Therefore, this systematic evaluation was carried out. In a meta-analysis examining the effects of sea-buckthorn on factors related to metabolic syndrome [ 31 ], it was determined that sea-buckthorn can effectively improve blood lipid levels in individuals with unhealthy lipid profiles, while having no significant impact on those who are already healthy. A systematic review was conducted to investigate the effects of turmeric on liver enzymes in patients with NAFLD [ 32 ], the study found that high-dose administration of turmeric can be used as a treatment for NAFLD.…”

Isorhamnetin: what is the in vitro evidence for its antitumor potential and beyond?

“…fruit as folk medicine. Hippophae rhamnoides L., is widely used in medicine by the Chinese Pharmacopoeia and the World Pharmacopoeia ( Geng et al, 2022 ). Notably, among the constituents, ISO accounts for the most important and representative ingredients of H. rhamnoides L .…”

“…These modern pharmacological studies supported most traditional uses of H. rhamnoides L. fruit as folk medicine. Hippophae rhamnoides L., is widely used in medicine by the Chinese Pharmacopoeia and the World Pharmacopoeia (Geng et al, 2022). Notably, among the constituents, ISO accounts for the most important and representative ingredients of H. rhamnoides L. It is rich in nutrients, bioactive substances and various amino acids required by the human body, especially high in vitamins.…”

Sea buckthorn plant as a functional food ingredient, with antioxidant and anti-inflammatory properties

“…The fatty acids, organic acids, amino acids, vitamins and minerals are also present in H. rhamnoides L. preparations (Sławińska et al, 2023b;Wang et al, 2022;Żuchowski, 2023). Moreover, it is a valuable plant with many biological and pharmacological properties described over the last 2 years by many authors: antioxidant (Nowak et al, 2022;, antimicrobial (Nowak et al, 2022;Wang et al, 2022), treating metabolic syndrome (Geng et al, 2022;Chen et al, 2023), anticancer (Visan et al, 2023), anti-osteoporosis (Park et al, 2022), antihyperlipidemic (Kopčeková et al, 2023), anti-inflammatory (Laskowska et al, 2022;Zhou et al, 2023), antifatigue effect (An et al, 2023), dermatological (Skowrońska and Bazylko, 2023), neuroprotective (Lan et al, 2023), hepatoprotective (Ma et al, 2023).…”