Effects of seasonal and pandemic influenza on health‐related quality of life, work and school absence in England: Results from the Flu Watch cohort study

Fragaszy, Ellen; Warren‐Gash, Charlotte; White, Peter J; Zambon, Maria; Edmunds, W. John; Nguyen‐Van‐Tam, Jonathan S; Hayward, Andrew

doi:10.1111/irv.12506

Cited by 56 publications

(57 citation statements)

References 21 publications

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“…Comparing our study to the Flu Watch prospective cohort study, we found that the QALY loss for an RSV episode is less than the QALY loss for a confirmed Influenza H1N1 episode, which is estimated to have mean 4·4 × 10 −3 (range -2·5–18·2 × 10 −3 ) across all ages. 22 However, our estimates are similar to the QALY loss for cases of respiratory disease in the same study which were not confirmed to be Influenza, but were confirmed to suffer from a fever and reported coughing/sore throat (mean 2·6 × 10 −3 (range -69·2–39·7 × 10 −3 ) across all ages). We cannot compare the QALY loss due to the confirmed RSV episodes in children under the age of five (3·823 × 10 −3 (95% CI 0·492–12·766 × 10 −3 )), with values from the Flu Watch because the confirmed RSV infections were recruited dependent on an infection being severe and requiring medical attention.…”

Section: Discussionsupporting

confidence: 79%

Estimates for quality of life loss due to RSV

Hodgson

Atkins

Baguelin

et al. 2018

Preprint

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33 34A number of vaccines against Respiratory Syncytial Virus (RSV) infection are approaching 35 licensure. Deciding which RSV vaccine strategy, if any, to introduce, will partly depend on cost-36 effectiveness analyses, which compares the relative costs and health benefits of a potential 37 vaccination programme. Health benefits are usually measured in Quality Adjusted Life Year 38 (QALY) loss, however, there are no QALY loss estimates for RSV that have been determined 39 using standardised instruments. Moreover, in children under the age of five years in whom 40 severe RSV episodes predominantly occur, there are no appropriate standardised instruments 41 to estimate QALY loss. We estimated the QALY loss due to RSV across all ages by developing 42 a novel regression model which predicts the QALY loss without the use of standardised 43 instruments. To do this, we conducted a surveillance study which targeted confirmed episodes 44 in children under the age of five years (confirmed cases) and their household members who 45 experienced symptoms of RSV during the same time (suspected cases.) All participants were 46 asked to complete questions regarding their health during the infection, with the suspected 47 cases aged 5-14 and 15+ years old additionally providing Health-Related Quality of Life (HR-48 QoL) loss estimates through completing EQ-5D-3L-Y and EQ-5D-3L instruments respectively. 49The questionnaire responses from the suspected cases were used to calibrate the regression 50 model. The calibrated regression model then used other questionnaire responses to predict the 51 HR-QoL loss without the use of EQ-5D instruments. The age-specific QALY loss was then 52 calculated by multiplying the HR-QoL loss on the worst day predicted from the regression 53 model, with estimates for the duration of infection from the questionnaires and a scaling 54 factoring for disease severity. Our regression model for predicting HR-QoL loss estimates that 55 for the worst day of infection, suspected RSV cases in persons five years and older who do and 56 do not seek healthcare have an HR-QoL loss of 0·616 (95% CI 0·155-1·371) and 0·405 (95% 57 CI 0·111-1·137) respectively. This leads to a QALY loss per RSV episode of 1·950 × 10 -3 (95% 58 CI 0·185 × 10 -3 -9·578 × 10 -3 ) and 1·543 × 10 -3 (95% CI 0·136 × 10 -3 -6·406 × 10 -3 ) respectively. 59For confirmed cases in a child under the age of five years who sought healthcare, our model 60 predicted a HR-QoL loss on the worst day of infection of 0·820 (95% CI 0·222-1·450) resulting 61 in a QALY loss per RSV episode of 3·823 × 10 -3 (95% CI 0·492 × 10 -3 -12·766 × 10 -3 ). Combing 62 these results with previous estimates of RSV burden in the UK, we estimate the annual QALY 63 loss of healthcare seeking RSV episodes as 1,199 for individuals aged five years and over and 64 1,441 for individuals under five years old. The QALY loss due to an RSV episode is less than 65 the QALY loss due to an Influenza episode. These results have important implications for 66 . CC-BY-ND 4.0 Inter...

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Section: Discussionsupporting

confidence: 79%

Estimates for quality of life loss due to RSV

Hodgson

Atkins

Baguelin

et al. 2018

Preprint

Self Cite

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“…Eighteen population‐specific articles have been included in this Special Edition—including five from Asia, four from Africa, four from Europe, three from North America, and one each from South America and the Middle East . (Figure and Table ) This reflects a broad geographical breadth of new research, and these data will add to our understanding of the burden of disease worldwide, especially in LMICs.…”

Section: New Series Of Burden Studiesmentioning

confidence: 99%

“…The most common outcomes were deaths attributable to influenza, used in nine studies, and severe acute respiratory infections (SARI) or its equivalent, used in eight studies . Another seven studies measured excess or absolute hospitalizations due to influenza, and five studies measured community or outpatient visits . Some studies were less representative for the entire country than others—there were 10 studies that collected data from across the country, although most national estimates were calculated with the help of extrapolations and appropriate adjustments for demographic differences …”

Section: New Series Of Burden Studiesmentioning

confidence: 99%

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Advances in measuring influenza burden of disease

Lee

Goh

et al. 2018

Influenza Resp Viruses

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“…The IPW-PS analysis, however, showed different results in the sensitivity analysis. Previous studies reported differently about difference of QOL score and duration of symptoms between influenza and ILI [32,33], so further work would be helpful in this specific area.…”

Section: Discussionmentioning

confidence: 93%

The Characteristics of Influenza-Like Illness Management in Japan

Tsuzuki

Yoshihara²

2020

Preprint

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Background: This study aimed to make a quantitative assessment of the management of influenza-like illnesses in Japanese healthcare settings. Methods: We analysed participants’ healthcare-seeking behaviour and physicians’ practice in January 2019 using an online survey of 200 households in Japan. Quality of life score, quality-adjusted life years lost, the duration of symptoms, and the duration of absence from work were compared between influenza group and influenza-like illness group with one-to-one propensity score matching. Missing data were imputed using multiple imputation. Results: In total, 261 of the 600 (43.5%) participants had at least one episode of influenza-like illness during January 2019. Of these, 194 (75.5%) visited healthcare facilities, 167 (86.1%) within 2 days of onset of symptoms. A total of 169 out of 191 (88.5%) received a rapid influenza diagnostic test and 101 were diagnosed with influenza, of whom 95.0% were treated with antivirals. The median quality-adjusted life-years lost was 0.0055 (interquartile range, IQR 0.0040–0.0072) and median absence from work for a single episode of influenza-like illness was 2 days (IQR 1–5 days). Conclusions: In Japan, most people with influenza-like illnesses visit healthcare facilities soon after symptoms first occur and receive a diagnostic test. Those with influenza are usually treated with antivirals. Absence from work was longer for influenza than other similar illnesses.

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Effects of seasonal and pandemic influenza on health‐related quality of life, work and school absence in England: Results from the Flu Watch cohort study

Cited by 56 publications

References 21 publications

Estimates for quality of life loss due to RSV

Estimates for quality of life loss due to RSV

Advances in measuring influenza burden of disease

The Characteristics of Influenza-Like Illness Management in Japan

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