Effects of seco-steroids purified from Physalis angulata L., Solanaceae, on the viability of Leishmania sp

Guimarães, Elisalva Teixeira; Lima, Milena S.; Santos, Luciane Amorim; Ribeiro, Ícaro José Santos; Tomassini, Therezinha Coelho Barbosa; Santos, Ricardo Ribeiro dos; Santos, Washington Luis Conrado dos; Soares, Milena Botelho Pereira

doi:10.1590/s0102-695x2010005000036

Cited by 32 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it is not possible to directly compare the inhibitory effects of this study with our results, since authors used axenic amastigote cultures instead of amastigotes inside host cells. In previous reports, Guimarães et al [14, 15] showed that physalins B, F and G, purified from stems of P. angulata, were able to reduce promastigote (IC 50 = 6.8, 1.4, and 9.2 μM, respectively) and axenic amastigotes number (IC 50 = 0.21 and 0.18 μM for Physalin B and F, respectively) and percentage of Leishmania -infected macrophages at concentrations non-cytotoxic to macrophages. However, no reports have described morphological alterations in parasites.…”

Section: Discussionmentioning

confidence: 97%

“…The phytochemistry of P.angulata is known to contain glucocorticoids, flavonoids, withanolides and physalins [13]. Among the compounds thought to be responsible for the leishmanicidal effects of P. angulata are the physalins, which have been mostly isolated from the plant’s stems and leaves [14, 15]. In addition, antiprotozoal effect of physalins was also been reported against Plasmodium sp .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis

Silva

Rodrigues

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundLeishmaniasis is an infectious disease caused by various species of the protozoan parasites of the Leishmania genus and transmitted by phlebotomine sandflies. The protozoa multiply in phagocytic cells, mainly macrophages, which play an important role defending the organism from pathogens. The most effective treatment for leishmaniasis is the chemotherapy and besides the high cost, these drugs are toxic and require a long period of treatment. Currently, some herbal products are considered an important alternative source of a new leishmanicidal agent, which includes the plant Physalis angulata, . We evaluated effects of an aqueous extract from roots of Physalis angulata (AEPa) on Leishmania proliferation, morphology and also determined whether physalins were present in the extract contributing to the knowledge of its pharmacological efficacy.MethodsMorphological alterations were determined by light microscopy, transmission and scanning electron microscopy. Host cell viability was evaluated by MTT, and propidium iodide. AEPa were submitted in full HRESITOF analysis.ResultsAEPa promoted a dose-dependent reduction on promastigotes (IC50 = 39.5 μg/mL ± 5.1) and amastigotes (IC50 = 43.4 μg/mL ± 10.1) growth. This growth inhibition was associated with several morphological alterations observed in promastigote forms. No cytotoxic effect in mammalian cells was detected (IC50 > 4000 μg/mL). Furthemore, the presence of physalins A, B, D, E, F, G and H were described, for the first time, in the P. angulata root.ConclusionsResults demonstrate that AEPa effectively promotes antileishmanial activity with several important morphological alterations and has no cytotoxic effects on host cells.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0717-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis

Silva

Rodrigues

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Even being a species with wide ecological adaptation, information about their cultivation still is scarce (Muniz et al 2011, Guimarães et al 2010, Lima et al 2006, Briguenti & Madeira 2007). This characteristic is contrasting, mainly because P. angulata is a species widely used in popular medicine as anti-coagulant, anti-leukemic, anti-mutagenic, anti-inflammatory, anti-spasmodic, antiseptic, analgesic and treatment of diabetes, among others (Lin et al 1992) thus, was expected that more information about their cultivation were available.…”

Section: Introductionmentioning

confidence: 99%

Physalis angulata L. (Solanaceae): a potential host-plant of stink bugs Edessa meditabunda F. (Hemiptera, Pentatomidae)

Krinski

2013

Biota Neotrop.

View full text Add to dashboard Cite

Physalis angulata is native to South America. In Brazil is popularly known as camapú, balãozinho, juá-de-capote, bucho-de-rã, camambu, mata-fome, bate-testa and balão-rajado. Even being a species with wide ecological adaptation the studies on pest insects associated with these plants are incipient. Thus, this study reports for the first time the occurrence of stink bugs Edessa meditabunda on plants P. angulata in the Amazon region. Resumo: Physalis angulata é nativa da América do Sul. No Brasil é popularmente conhecida como camapú, balãozinho, juá-de-capote, bucho-de-rã, camambu, mata-fome, bate-testa e balão-rajado. Mesmo sendo uma espécie com ampla adaptação ecológica, os estudos sobre a presença de possíveis insetos pragas associados a estas plantas são incipientes. Desta forma, este trabalho relata pela primeira vez a ocorrência de percevejos Edessa meditabunda em plantas de P. angulata na região amazônica. Palavras-chave: inseto-praga, planta reservatório, percevejo asa-preta, região Neotropical. 337Physalis angulata: a potential host-plant of stink bugs Edessa meditabunda

show abstract

“…Physalins (Fig. 2) have both anti-leishmanial and anti-malarial potential [54, 55]. Four types of physalins B, D, G and F (Fig.…”

Section: Active Phyto-compounds Against Leishmania and Plasmodia Paramentioning

confidence: 99%

Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites

Tariq

Adnan

Amber

et al. 2016

Ann Clin Microbiol Antimicrob

View full text Add to dashboard Cite

BackgroundLeishmaniasis and malaria are the two most common parasitic diseases and responsible for large number of deaths per year particularly in developing countries like Pakistan. Majority of Pakistan population rely on medicinal plants due to their low socio-economic status. The present review was designed to gather utmost fragmented published data on traditionally used medicinal plants against leishmaniasis and malaria in Pakistan and their scientific validation.MethodsPub Med, Google Scholar, Web of Science, ISI Web of knowledge and Flora of Pakistan were searched for the collection of data on ethnomedicinal plants. Total 89 articles were reviewed for present study which was mostly published in English. We selected only those articles in which complete information was given regarding traditional uses of medicinal plants in Pakistan.ResultsTotal of 56 plants (malaria 33, leishmaniasis 23) was found to be used traditionally against reported parasites. Leaves were the most focused plant part both in traditional use and in in vitro screening against both parasites. Most extensively used plant families against Leishmaniasis and Malaria were Lamiaceae and Asteraceae respectively. Out of 56 documented plants only 15 plants (Plasmodia 4, Leishmania 11) were assessed in vitro against these parasites. Mostly crude and ethanolic plant extracts were checked against Leishmania and Plasmodia respectively and showed good inhibition zone. Four pure compounds like artemisinin, physalins and sitosterol extracted from different plants proved their efficacy against these parasites.ConclusionsPresent review provides the efficacy and reliability of ethnomedicinal practices and also invites the attention of chemists, pharmacologist and pharmacist to scientifically validate unexplored plants that could lead toward the development of novel anti-malarial and anti-leishmanial drugs.

show abstract

Effects of seco-steroids purified from Physalis angulata L., Solanaceae, on the viability of Leishmania sp

Cited by 32 publications

References 13 publications

In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis

In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis

Physalis angulata L. (Solanaceae): a potential host-plant of stink bugs Edessa meditabunda F. (Hemiptera, Pentatomidae)

Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites

Contact Info

Product

Resources

About