Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study

Kohmura, Kunihiro; Iwamoto, Kunihiro; Aleksić, Branko; Sasada, Kazumi; Kawano, Naoki; Katayama, Hiroto; Noda, Yukihiro; Noda, Akiko; Iidaka, Tetsuya; Ozaki, Norio

doi:10.1007/s00213-012-2885-8

Cited by 27 publications

(18 citation statements)

References 28 publications

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“…For example, Kohmura et al (2013) examined the effects of sedative antidepressants on NIRS signals in a randomized controlled trial. They found that the administration of mirtazapine (15 mg for 8 consecutive days) increased [oxy-Hb] values during VFT, whereas trazodone (25 mg for 8 days) and a placebo did not have any significant effects on NIRS signals.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies including healthy volunteers have shown the significant effects of antidepressants on NIRS signals (Tsujii et al, 2007, Tsujii et al, 2009, Kohmura et al, 2013), although studies including patients with psychiatric disorders have shown inconsistent results (Noda et al, 2012, Takizawa et al, 2014). Moreover, investigations of the effects of other psychotropic drugs, such as benzodiazepines and antipsychotics, on NIRS signals are rare.…”

Section: Introductionmentioning

confidence: 99%

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High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study

Takamiya

Hirano

Ebuchi

et al. 2017

NeuroImage: Clinical

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BackgroundRecent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown.MethodsWe conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). We investigated the associations between the DDD of psychotropic medications and oxygenated hemoglobin (oxy-Hb) in single channel levels.LimitationsRetrospective study design and small sample size are the main limitations.ResultsMultiple regression analysis revealed that one channel in the right temporoparietal region had a significant association with antidepressant DDD controlling for age, sex, depression severity, and the DDD of antipsychotics and benzodiazepines. Moreover, high doses of antidepressants had significant effects on NIRS signals compared with low doses, in group comparisons.ConclusionsThe dose-dependent impact of antidepressants on NIRS signals should be taken into account when interpreting NIRS data.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study

Takamiya

Hirano

Ebuchi

et al. 2017

NeuroImage: Clinical

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“…Second, in this study, 13 subjects were taking psychotropic medications. Given that antidepressants have been reported to affect hemodynamic responses,37 a medication effect cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Hirosawa¹,

Narumoto²,

Nishida³

et al. 2013

NDT

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BackgroundNear-infrared spectroscopy has helped our understanding of the neurobiological mechanisms of psychiatric disorders and has advantages including noninvasiveness, lower cost, and ease of use compared with other imaging techniques, like functional magnetic resonance imaging. The verbal fluency task is the most common and well established task used to assess cognitive activation during near-infrared spectroscopy. Recent functional neuroimaging studies have shown that the orbitofrontal cortex and other brain regions, including the dorsolateral prefrontal cortex, may play important roles in the pathophysiology of obsessive-compulsive disorder (OCD). This study aimed to evaluate hemodynamic responses in the dorsolateral prefrontal cortex in patients with OCD using near-infrared spectroscopy during the verbal fluency task and to compare these with dorsolateral prefrontal cortex responses in healthy controls.MethodsTwenty patients with OCD and 20 controls matched for age, gender, handedness, and estimated intelligence quotient participated in this study. The verbal fluency task was used to elicit near-infrared spectroscopic activation and consisted of a 30-second pre-task, followed by three repetitions of a 20-second verbal fluency task (total 60 seconds), followed by a 70-second post-task period. The near-infrared spectroscopy experiment was conducted on the same day as surveys of obsessive-compulsive symptoms, depression, and anxiety. Z-scores for changes in the concentration of oxygenated hemoglobin were compared between the OCD patients and controls in 14 channels set over the left and right dorsolateral prefrontal cortex and frontopolar areas.ResultsDuring the verbal fluency task, significant task-related activation was detected in both the OCD group and the controls. Changes in oxygenated hemoglobin concentration in the right dorsolateral prefrontal cortex were significantly smaller in the OCD group than in the controls, but were not statistically significant after correction for multiple comparisons.ConclusionPatients with OCD have reduced prefrontal, especially right dorsolateral prefrontal, cortical hemodynamic responses as measured by near-infrared spectroscopy during the verbal fluency task. These results support the hypothesis that the dorsolateral prefrontal cortex plays a role in the pathophysiology of OCD.

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“…Previous studies have shown that acetylcholine-esterase inhibitors influence neurovascular coupling [47]. Other studies have reported that administration of antidepressants have influence on [oxy-Hb] changes [48-50]. However, a review of neuroimaging studies on bipolar disorder by Phillip et al [51] reported neither significant nor ameliorative effects of psychotropic medications on abnormal structural and functional neuroimaging measures.…”

Section: Discussionmentioning

confidence: 99%

Comparison of alterations in cerebral hemoglobin oxygenation in late life depression and Alzheimer’s disease as assessed by near-infrared spectroscopy

Kito

Ryokawa

Kinoshita

et al. 2014

Behavioral and Brain Functions

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BackgroundPatients with Alzheimer’s disease (AD) often present with apathy symptoms resembling the decreased motivation observed in depressed patients. Therefore, differentiating the initial phase of AD from late life depression may be difficult in some cases. Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that uses near-infrared light to measure changes in hemoglobin concentration on the cortical surface during activation tasks. The objective of this study was to investigate differences in brain activation associated with late life depression and with AD by means of NIRS.MethodsNIRS was performed in 30 patients with depression, 28 patients with AD, and 33 healthy controls, all aged 60 years or older. During two tasks, a verbal fluency task and a visuospatial task, changes in oxygenated hemoglobin concentration in the frontal and parietal cortices were investigated.ResultsIn the visuospatial task, cortical activation was lower in the depressed group than in the AD group, and significant differences were observed in the parietal cortex.ConclusionsNIRS can detect differences in brain activation between patients with late life depression and those with AD. NIRS is a promising tool for the differential diagnosis of late life depression and AD.

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Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study

Abstract: Administration of mirtazapine for eight consecutive days affected oxy-Hb changes on NIRS. This result indicates that researchers should consider how certain types of antidepressant could influence brain function when the brain activity of patients with psychiatric disorders is assessed.

Cited by 27 publications

References 28 publications

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study

High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study

Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Comparison of alterations in cerebral hemoglobin oxygenation in late life depression and Alzheimer’s disease as assessed by near-infrared spectroscopy

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