Effects of sediment-associated copper to the deposit-feeding snail, Potamopyrgus antipodarum: A comparison of Cu added in aqueous form or as nano- and micro-CuO particles

Pang, Chengfang; Selck, Henriette; Misra, Superb K.; Berhanu, Déborah; Dybowska, Agnieszka; Valsami-Jones, Eugénia; Forbes, Valery E.

doi:10.1016/j.aquatox.2011.10.005

Cited by 77 publications

(66 citation statements)

References 52 publications

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“…Mortality in the 6-nm CuO treatment was almost twice as high as in the aqueous Cu treatment and 10 times higher than in the 100-nm CuO treatment by the end of the exposure period, suggesting that the toxicity of CuO nanoparticles was not only related to dissolution and release of Cu 2þ ions. These results are consistent with another study on CuO nanoparticle effects on the reproduction in P. antipodarum [16], which showed that 6-nm CuO nanoparticles added to sediment had greater effects on reproduction than Cu added to sediment in aqueous form. The higher toxicity of small CuO nanoparticles compared with aqueous Cu may be due to a different cellular uptake route of particulate versus aqueous Cu by P. antipodarum.…”

Section: Toxicokineticssupporting

confidence: 95%

“…These concentrations were chosen on the basis of previous work [16] to cover a range of Cu concentrations at which effects were likely to occur but not result in substantial snail mortality, and at which Cu body burdens would be detectable. Stock sediments of the different Cu forms were made by adding Cu dissolved (aqueous)/dispersed (micro-and nanoCuO) in deionized water to wet sediment, which was mixed for 24 h on a shaking table.…”

Section: Sediment Spikingmentioning

confidence: 99%

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Bioaccumulation, toxicokinetics, and effects of copper from sediment spiked with aqueous Cu, nano-CuO, or micro-CuO in the deposit-feeding snail, Potamopyrgus antipodarum

Pang

Selck

Banta

et al. 2013

Environmental Toxicology and Chemistry

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The present study examined the relative importance of copper (aqueous Cu and CuO particles of different sizes) added to sediment to determine the bioaccumulation, toxicokinetics, and effects in the deposit feeder Potamopyrgus antipodarum. In experiment 1, the bioaccumulation of Cu (240 µg Cu/g dry wt of sediment) added as aqueous Cu (CuCl2 ), nano- (6 nm, 100 nm), or micro- (<5 µm) CuO particles in adult snails was measured. In experiment 2, a more comprehensive analysis of the toxicokinetics of Cu (aqueous Cu, 6 nm, or 100 nm) was conducted. In experiment 3, the effects of Cu form (aqueous Cu and 6 nm CuO) on juvenile growth and survival at 0, 30, 60, 120, and 240 µg Cu/g dry weight sediment were assessed. Snails took up less of the 5-µm CuO particles than nano-CuO or aqueous Cu. A substantial fraction of Cu taken up was associated with shell, and this was rapidly lost when snails were transferred to clean sediment. Net uptake rates from sediment amended with 6 nm CuO and aqueous Cu were significantly higher (∼40-50%) than from sediment amended with 100 nm CuO. During 2 wk of depuration, there were no significant differences in depuration rates (kd ) among forms (aqueous Cu: kd = -0.12 wk(-1) ; 6 nm CuO: kd = -0.22 wk(-1) ; 100 nm CuO: kd = -0.2 wk(-1) ). Average juvenile growth was reduced by 0.11 mm (41%) at measured exposure concentrations of 127.2 µg Cu/g dry weight sediment for aqueous Cu and 71.9 µg Cu/g dry weight sediment for 6 nm CuO compared with control; however, differences between forms were not statistically significant. Juvenile snails in the highest exposure concentrations (aqueous Cu and 6-nm CuO groups pooled) reduced their growth by 0.18 mm on average (67%) compared with the control group. Although we observed minor differences in toxicity among Cu forms, effects on juvenile snail growth occurred at bulk sediment concentrations lower than those in the Canadian interim sediment quality guidelines. Characterization of the CuO particles showed that particle size distributions of commercially prepared particles deviated substantially from the manufacturers' specifications and highlighted the importance of fully characterizing particles when using them in toxicity tests.

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Section: Toxicokineticssupporting

confidence: 95%

Section: Sediment Spikingmentioning

confidence: 99%

Bioaccumulation, toxicokinetics, and effects of copper from sediment spiked with aqueous Cu, nano-CuO, or micro-CuO in the deposit-feeding snail, Potamopyrgus antipodarum

Pang

Selck

Banta

et al. 2013

Environmental Toxicology and Chemistry

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“…Both aqueous and CuO NP exposures are reported to induce behavioral impairments in clams, but only exposure to aqueous Cu (and not CuO NPs) is found to impair the burrowing activity in ragworms (Buffet et al, 2011). In contrast, Pang et al (2012) concluded that the bioavailability and toxicity of CuO NPs are greater to the gastropod Potamopyrgus antipodarum than Cu added as aqueous Cu or micro-sized CuO. These Cu form-and species-specific differences are presumably related to differences in feeding behavior and physiology (e.g., gut retention time, assimilation efficiency, and pH in gut).…”

Section: Introductionmentioning

confidence: 94%

“…There is evidence that Cu administered in both aqueous (i.e., Cu ions and other Cu species) and nanoparticulate forms are accumulated both from water and diet (including sediment) by a number of sediment-burrowing organisms, such as gastropods, clams and ragworms (Buffet et al, 2013;Pang et al, 2012). However, it remains unclear which Cu form is most bioavailable and toxic to invertebrates.…”

Section: Introductionmentioning

confidence: 98%

Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete – Part I: Relative importance of water and sediment as exposure routes

et al. 2015

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“…[1][2][3][4][5][6][7][8][9][10] Although in the vast nanotoxicological literature of the last decade studies concerned with the assessment of metal or metal-oxide NP toxicity are not at the top of the list, such publications are nevertheless quite numerous. To illustrate this, we may refer to several works devoted to NPs of the metals that were the subject-matter of our own studies considered below: iron oxide, [11][12][13][14][15][16][17][18][19][20] silver, gold, 24,[45][46][47][48][49][50][51][52][53][54][55][56][57][58] copper and copper oxide, 43,[59][60][61][62][63][64][65][66][67][68] nickel oxide, 65,[69]…”

mentioning

confidence: 99%

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

Katsnelson¹,

Privalova²,

Sutunkova³

et al. 2015

IJN

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The purpose of this paper is to overview and summarize previously published results of our experiments on white rats exposed to either a single intratracheal instillation or repeated intraperitoneal injections of silver, gold, iron oxide, copper oxide, nickel oxide, and manganese oxide nanoparticles (NPs) in stable water suspensions without any chemical additives. Based on these results and some corroborating data of other researchers we maintain that these NPs are much more noxious on both cellular and systemic levels as compared with their 1 μm or even submicron counterparts. However, within the nanometer range the dependence of systemic toxicity on particle size is intricate and non-unique due to complex and often contra-directional relationships between the intrinsic biological aggressiveness of the specific NPs, on the one hand, and complex mechanisms that control their biokinetics, on the other. Our data testify to the high activity of the pulmonary phagocytosis of NPs deposited in airways. This fact suggests that safe levels of exposure to airborne NPs are possible in principle. However, there are no reliable foundations for establishing different permissible exposure levels for particles of different size within the nanometric range. For workroom air, such permissible exposure levels of metallic NP can be proposed at this stage, even if tentatively, based on a sufficiently conservative approach of decreasing approximately tenfold the exposure limits officially established for respective micro-scale industrial aerosols. It was shown that against the background of adequately composed combinations of some bioactive agents (comprising pectin, multivitamin-multimineral preparations, some amino acids, and omega-3 polyunsaturated fatty acid) the systemic toxicity and even genotoxicity of metallic NPs could be markedly attenuated. Therefore we believe that, along with decreasing NP-exposures, enhancing organisms’ resistance to their adverse action with the help of such bioprotectors can prove an efficient auxiliary tool of health risk management in occupations connected with them.

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Effects of sediment-associated copper to the deposit-feeding snail, Potamopyrgus antipodarum: A comparison of Cu added in aqueous form or as nano- and micro-CuO particles

Cited by 77 publications

References 52 publications

Bioaccumulation, toxicokinetics, and effects of copper from sediment spiked with aqueous Cu, nano-CuO, or micro-CuO in the deposit-feeding snail, Potamopyrgus antipodarum

Bioaccumulation, toxicokinetics, and effects of copper from sediment spiked with aqueous Cu, nano-CuO, or micro-CuO in the deposit-feeding snail, Potamopyrgus antipodarum

Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete – Part I: Relative importance of water and sediment as exposure routes

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

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