Effects of Selected Antioxidant Vitamins on Lipid Profile in Early Pregnancy

Iribhogbe, Osede Ignis; Aigbiremol, A.; Akpamu, U; Emordi, J.E.; Nwoke, E.O.

doi:10.3923/ajsr.2011.62.70

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study with human subjects, vitamin C supplementation increased plasma lipid-standardized α-tocopherol [ 30 ]. Iribhogbe et al [ 31 ] concluded that the synergetic potential of antioxidant vitamin combinations appears to be beneficial in the management of pregnancy-related hyperlipidemic states.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

Torkzahrani

Heidari

Mostafavi‐Pour

et al. 2014

Clin Exp Reprod Med

View full text Add to dashboard Cite

ObjectiveCombined oral contraceptives (COCs) have some adverse effects on the serum lipid profile. Because hyperlipidemia is one of the risk factors in cardiovascular diseases, lipid abnormalities should be evaluated in women consuming COCs. Vitamins E and C are known to have beneficial effects on serum lipid profiles. Therefore, in this study, we evaluated the effects of vitamins E and C on serum lipids in women using COCs.MethodsThe study compared changes in lipid parameters with and without vitamin therapy in women consuming COCs compared to those of a control group (40 non-contraceptive users or NCU) for 4 weeks. Total cholesterol and triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels along with HDL/LDL ratios were measured for all participants.ResultsCOC users experienced significantly higher increases in the levels of triglycerides and LDL than non-users (p<0.05). However, no significant differences were noted in the total cholesterol and HDL levels. In the treated COC group receiving vitamins E and C, the HDL level and the HDL/LDL ratio increased and the LDL and triglycerides levels decreased significantly compared with those of the other groups.ConclusionThe results of our study indicate that supplementation with antioxidant vitamins E and C restores a normal lipid profile in COC users.

show abstract

Section: Discussionmentioning

confidence: 99%

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

Torkzahrani

Heidari

Mostafavi‐Pour

et al. 2014

Clin Exp Reprod Med

View full text Add to dashboard Cite

show abstract

“…Administration of MTX induces oxidative stress and significantly reduces antioxidant enzymes such as superoxide dismutase; however, it is known that cells are protected against oxidative stress by the action of certain enzymes, vitamins, and other substances, collectively known as antioxidants [3]. Vitamins are ideal antioxidants to increase tissue protection from oxidative stress due to their easy, effective and safe dietary administration in a large range of concentrations without harmful side effect [4]. Vitamin A is a potent antioxidant and acts as a scavenger of free radicals either independently or as a part of large enzyme system [5].…”

mentioning

confidence: 99%

Study the Effects of Methotrexate with and without Vitamin A on Some Biochemical and Histological Parameters in Male Rabbits

Al-Lami¹,

Sail²,

Al-Chalabi³

et al. 2017

JoBRC

View full text Add to dashboard Cite

The present study aims to evaluate the effects of methotrexate (MTX) with and without vitamin A (Vit. A) on some biochemical parameters and histological structure in male rabbits liver. Twenty male rabbits weighing 1250-1480 gm were divided into four equal number groups. The first group was given 2 ml distilled water as control group. The second group was given MTX (20 mg/kg), the third group was given Vit. A (5000 IU), while the fourth group was given MTX (20 mg/kg) +Vit. A (5000 IU) in alternative days. Following four weeks of treatment, lipid profile total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), [low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL)]; in addition to thyroid hormones triiodothyronine (T3) and thyroxin (T4)] and liver enzymes [glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT)] were determined in the serum. Also, the histological examination of liver of all the experimental groups were carried out. The results were revealed that the treatment with MTX caused a significant P≤0.05 increases in TC, HDL, LDL, T4, and GPT when compared with the control group. The treatment with Vit. A did not cause any significant P≥0.05 differences in all the studied parameters. The MTX+Vit. A treated group showed a significant P≤0.05 increases only in GPT compared with the control group; while a significant P≤0.05 decreases was found in TC, HDL, T3, T4, and GOT when compared with the MTX treated group. The histological examination of the liver sections showed that MTX administration caused major histological changes in comparison with the control such as inflammatory cell infiltrations, vascular congestion, sinusoidal dilatation and granular degeneration of hepatocytes. Treatment with Vit. A showed a typical structure in liver tissue. While in MTX+Vit. A group, the histological changes were less severe than those in the MTX treated group; these changes were granular degeneration of hepatocytes and sinusoidal dilatation at low levels. The overall results of this study confirmed that administration of Vit. A decreased the side effects of MTX; this protective effect of Vit. A may have clinical applications in chemotherapy.

show abstract

Hepatoprotective Effect of Feeding Celery Leaves Mixed with Chicory Leaves and Barley Grains to Hypercholesterolemic Rats

Belal¹

2010

Asian J. of Clinical Nutrition

View full text Add to dashboard Cite

Effects of Selected Antioxidant Vitamins on Lipid Profile in Early Pregnancy

Cited by 4 publications

References 0 publications

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

Study the Effects of Methotrexate with and without Vitamin A on Some Biochemical and Histological Parameters in Male Rabbits

Hepatoprotective Effect of Feeding Celery Leaves Mixed with Chicory Leaves and Barley Grains to Hypercholesterolemic Rats

Contact Info

Product

Resources

About