Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Ahmad, Ajaz; Khan, Rao Muzaffar A.; Alkharfy, Khalid M.

doi:10.1097/fjc.0b013e3182927e47

Cited by 27 publications

(15 citation statements)

References 146 publications

(174 reference statements)

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“…The overproduction of ROS is thought to be involved in diseases, such as cardiovascular and thrombotic diseases [1,4,17,25,34]. Human platelet aggregation has been shown to be very sensitive to oxidative stress, although platelets also require ROS generation during their activation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

et al. 2015

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Beneficial effects of the antioxidant L-ascorbic acid (Asc) in human health are well known. Its particular role in hemostasis deserves further consideration, since it has been described a dose-dependent effect of Asc in platelet activity. Contrary, it has been demonstrated that phenolic compounds have inhibitory effects on platelet aggregation stimulated by the physiological agonist thrombin (Thr). Here, we have evaluated the actions of three synthetic phenolic esters of Asc: L-ascorbyl 6-protocatechuate (Prot Asc), L-ascorbyl 6-gallate (Gal Asc), and L-ascorbyl 6-caffeate (Caf Asc). All these Asc derivatives exhibited greater radical scavenging activity than Asc, and in experiments using human platelets from healthy subjects, they do not evoke changes in platelet viability upon their administration. Nevertheless, these compounds altered platelet calcium homeostasis in response to Thr, although Prot Asc induced a smaller effect than Gal Asc, Caf Asc, and Asc. As a consequence, platelet aggregation was also impaired by these compounds, reporting Prot Asc and Caf Asc a weaker antiaggregant action than Gal Asc and Asc. Treatments with Gal Asc and Caf Asc altered in larger extent the phosphorylation pattern of pp60(Src) and mammalian target of rapamycin (mTOR) evoked by stimulating human platelets with Thr. Summarizing, Prot Asc is the ascorbyl phenolic ester with the strongest antioxidant properties and weakest antiaggregant actions, and its use as antioxidant may be safer than the rest of derivatives in order to prevent thrombotic alteration in patients that need treatment with antioxidant therapies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

et al. 2015

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“…Because allicin suppressed the degradation of Iκ‐B, it was suggested that inhibition of the NF‐κB pathway of allicin would probably diminish the amplification of NF‐κB‐mediated cytokine secretion . However, allicin is generally considered as an unstable compound .…”

Section: Discussionmentioning

confidence: 99%

The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor‐kappa B activation in human gingival fibroblasts

Tsai

Chin

et al. 2014

J of Periodontal Research

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“…The concentration used is based on a previous study [7] . Allicin was considered the main active constituent of GE [8] .…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

Reda

Fattah

Helmi

et al. 2017

Journal of Medical Histology

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Background and Objectives: Chronic wounds represent a significant health problem. Novel therapeutic approaches to wound healing are required. Garlic (Allium sativum) was considered to exert antioxidant, antibacterial, and anticholesterol activities. Aim of the work: The present work aimed at investigating the possible therapeutic effect of garlic extract (GE) on induced wound in male albino rat. The possible role of endogenous stem cells was also determined. Materials and Methods: 26 adult male albino rats were divided into Group I (Control group): 6 rats not exposed to wound induction.Group II (Wounded group): 10 rats were exposed to wound induction and subdivided into subgroups IIa and IIb, 5 animals each, were sacrificed 2 and 3 weeks following wound induction. Group III (Wounded and GE treated group): 10 rats were exposed to wound induction and subdivided as in group II. 0.5 ml of 1% GE was locally applied following wound induction. Skin specimens (including the wound and a margin of normal skin around) were subjected to histological, immunohistochemical, morphometric and statistical studies. Results: Morphological changes, indicating inflammation and degeneration, were found in wounded rats. These changes regressed remarkably by the use of GE. The regression of apoptosis was confirmed by caspase3 immunostaining and the activation of stem cells was proved by CD44 immunostaining. Conclusions: GE therapeutic effect was proved to be related to both caspase3 pathway inactivation and MSC migration activation. GE was suggested to be applied in appropriate concentrations in the preparation of pharmaceutical products to be used safely on epithelial cells in wound care.

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Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Cited by 27 publications

References 146 publications

Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor‐kappa B activation in human gingival fibroblasts

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

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