Effects of selective inner hair cell loss on auditory nerve fiber threshold, tuning and spontaneous and driven discharge rate

Auditory Neuropathy/Dys-synchrony and Its Perceptual Consequences

“…When outer hair cells are damaged by aminoglycosides or acoustic over-stimulation, for example, the result is a significant broadening of both psychophysical and neural tuning curves (i.e., reduced frequency resolution ability) (Ryan and Dallos, 1975;Evans and Harrison, 1976;Liberman et al, 1986). In contrast, damage to the inner hair cells through carboplatin treatment results in significant loss of sensitivity but normal frequency resolution ability provided there is full outer hair cell retention and provided the active process mechanisms-typically inferred in animal studies from the presence of otoacoustic emissions-are functional (Wang et al, 1997;Salvi et al, 1999).…”

Resting Potential and Submembrane Calcium Concentration of Inner Hair Cells in the Isolated Mouse Cochlea Are Set by KCNQ-Type Potassium Channels

“…Alternatively, hearing loss in DFNA2 may result from a defective afferent signal transmission, from either a defective central auditory pathway whose neurons are known to express KCNQ4 (Kharkovets et al, 2000) or functional defects in inner hair cells (IHCs) (Takeno et al, 1994;Wang et al, 1997). Information on expression of KCNQ4 in IHCs, however, has been contradictory.…”

A novel cochlea partition model based on asynchronous bifurcation processor

“…8 in Fig Figure 10 shows conceptual sketches of the characteristics of two cochlea partitions of a chinchilla cat for input sound frequencies [5]. It can be seen that the cochlea partitions work as nonlinear band-pass filters and thus the characteristics curves in Fig.…”

“…The spiral ganglion cells encode the receptor potential V I of the inner hair cell into parallel spike-trains, which are transmitted to the central nervous system. Due to its high nonlinearities, the whole cochlea (i.e., connected compartments of cochlea partition) exhibits a huge variety of nonlinear responses such as nonlinear DC response [4], nonlinear band-pass filtering [5][6][7], adaptation of spike density [8], multi-tone suppression [9,10], spike density modulation [11], missing fundamental, first pitch shift, second pitch shift, and so on (see also reviews in [1][2][3]). Among them, the nonlinear DC response, the nonlinear band-pass filtering, and the adaptation of spike density are important research topics when the cochlea partition is to be investigated like this paper since the other nonlinear responses are caused by connections of the compartments of the cochlea partition.…”

“…Among them, the nonlinear DC response, the nonlinear band-pass filtering, and the adaptation of spike density are important research topics when the cochlea partition is to be investigated like this paper since the other nonlinear responses are caused by connections of the compartments of the cochlea partition. In order to understand such complicated nonlinear responses of the cochlea partition and the whole cochlea, many mathematical models have been presented and analyzed intensively [1][2][3][4][5][6][7][8][9][10][11].…”