Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat

Ayaz, Murat; Özdemir, Semir; Uğur, Mehmet; Vassort, Guy; Turan, Belma

doi:10.1016/j.abb.2004.03.030

Cited by 67 publications

(69 citation statements)

References 37 publications

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“…Several studies demonstrated that Se prevents or alleviates the adverse effects that diabetes has on cardiac and renal functions, vascular complications, and atherosclerosis progression. 229,230 Observational studies on Se supplementation have shown that the element can have insulin-mimetic properties, being effective in the stimulation of glucose uptake both in vitro and in vivo, the regulation of glycolysis, gluconeogenesis, fatty acid synthesis and the pentose phosphate pathway. 231 Selenate in particular has been proposed to influence two important mechanisms involved in insulin resistance: firstly it reduces the activity of liver cytosolic protein tyrosine phosphatases (PTPs) as negative regulators of insulin signalling; and secondly it increases the expression of the peroxisome proliferatoractivated receptor gamma (PPARg).…”

Section: Diabetesmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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Section: Diabetesmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

View full text Add to dashboard Cite

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“…PKC is known to phosphorylate a number of proteins that are directly involved in cardiac excitation-contraction coupling (8,24,25). Therefore, upregulation of cardiac RAS and increased PKC activity in diabetic animals suggest the importance of these pathways in the development of cardiac complications.Defects in cardiac intracellular Ca 2ϩ have been proposed as one possible contributory factor to the depressed myocardial contractile activity in diabetic cardiomyopathy (1,32). Most alterations were attributed to anomalous sarcoplasmic reticulum (SR) pump activity (15), SR-Ca 2ϩ storage (5), and partly to alterations in RyR2 properties (3,27,35,49,51).…”

mentioning

confidence: 99%

“…Defects in cardiac intracellular Ca 2ϩ have been proposed as one possible contributory factor to the depressed myocardial contractile activity in diabetic cardiomyopathy (1,32). Most alterations were attributed to anomalous sarcoplasmic reticulum (SR) pump activity (15), SR-Ca 2ϩ storage (5), and partly to alterations in RyR2 properties (3,27,35,49,51).…”

mentioning

confidence: 99%

Restoration of diabetes-induced abnormal local Ca²⁺release in cardiomyocytes by angiotensin II receptor blockade

Yaraş

Bilginoglu²,

Vassort³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Stimulation of local renin-angiotensin system and increased levels of oxidants characterize the diabetic heart. Downregulation of ANG II type 1 receptors (AT1) and enhancement in PKC activity in the heart point out the role of AT1 blockers in diabetes. The purpose of this study was to evaluate a potential role of an AT1 blocker, candesartan, on abnormal Ca 2ϩ release mechanisms and its relationship with PKC in the cardiomyocytes from streptozotocin-induced diabetic rats. Cardiomyocytes were isolated enzymatically and then incubated with either candesartan or a nonspecific PKC inhibitor bisindolylmaleimide I (BIM) for 6 -8 h at 37°C. Both candesartan and BIM applied on diabetic cardiomyocytes significantly restored the altered kinetic parameters of Ca 2ϩ transients, as well as depressed Ca 2ϩ loading of sarcoplasmic reticulum, basal Ca 2ϩ level, and spatiotemporal properties of the Ca 2ϩ sparks. In addition, candesartan and BIM significantly antagonized the hyperphosphorylation of cardiac ryanodine receptor (RyR2) and restored the depleted protein levels of both RyR2 and FK506 binding protein 12.6 (FKBP12.6). Furthermore, candesartan and BIM also reduced the increased PKC levels and oxidized protein thiol level in membrane fraction of diabetic rat cardiomyocytes. Taken together, these data demonstrate that AT 1 receptor blockade protects cardiomyocytes from development of cellular alterations typically associated with Ca 2ϩ release mechanisms in diabetes mellitus. Prevention of these alterations by candesartan may present a useful pharmacological strategy for the treatment of diabetic cardiomyopathy.heart; candesartan; Type 1 diabetes; thiol oxidation CHRONIC DIABETES ALTERS the structure and function of the human heart, and individuals with diabetes mellitus usually develop a specific cardiac dysfunction known as diabetic cardiomyopathy (37). Several mechanisms involved in the development of cardiomyopathy have been postulated, including alterations in intracellular ion homeostasis and glucose metabolism and enhanced oxidative stress. Although alteration of Ca 2ϩ signaling via changes in critical processes that regulate intracellular Ca 2ϩ has become a hallmark of this type of cardiomyopathy, controversies, currently going on, relate to specific alterations in Ca 2ϩ signaling pathways contributing to the cardiac defects in diabetes (7,20). Recently, we reported that these defects result partially from altered local Ca 2ϩ signaling due to a dysfunction of cardiac PKA-mediated ryanodine receptor Ca 2ϩ release channel (RyR2) (51).Several mechanisms have been proposed to explain how all of the pathologies involved in the progression of diabetic cardiomyopathy might result from hyperglycemia. Increased PKC isoform expression and increased polyol pathway flux are two main hypotheses presented to describe how hyperglycemia might cause all of the diabetic complications (6). Furthermore, it has been demonstrated that hyperglycemia activates the local renin-angiotensin system (RAS) and enhanced RAS activity in diabetes (3...

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“…15) In addition, it is reported that extracellular selenite may affect to ion channels of cardiac muscles and change ion currents. [16][17][18] Selenite is more toxic than selenate in general. The SeC model in this experiment was chronically exposed to selenate in drinking water with 0.1 mg selenium/l from the pregnant of their mother.…”

Section: Discussionmentioning

confidence: 99%

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Matsumoto

Ariyoshi

Terada

et al. 2006

JOURNAL OF HEALTH SCIENCE

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Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat

Cited by 67 publications

References 37 publications

Selenium biochemistry and its role for human health

Selenium biochemistry and its role for human health

Restoration of diabetes-induced abnormal local Ca²⁺release in cardiomyocytes by angiotensin II receptor blockade

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

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Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat

Cited by 67 publications

References 37 publications

Selenium biochemistry and its role for human health

Selenium biochemistry and its role for human health

Restoration of diabetes-induced abnormal local Ca2+release in cardiomyocytes by angiotensin II receptor blockade

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

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Restoration of diabetes-induced abnormal local Ca²⁺release in cardiomyocytes by angiotensin II receptor blockade