Effects of Selenium on Liver and Muscle Contents and Urinary Excretion of Zinc, Copper, Iron and Manganese

Monedero-Prieto, María José; González-Pérez, J.M.; González‐Reimers, Emilio; Hernández-Pérez, Onán; Monereo-Muñoz, María; Galindo-Martín, L.; Quintero-Platt, Geraldine; Abreu-González, Pedro

doi:10.1007/s12011-014-9928-4

Cited by 8 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, these authors revealed a slight tendency towards liver copper decrease in animals given selenium [19], which confirms the results of the current study. The negative relationship between selenium and copper is also supported by the study performed by Nwagha et al; they found that in the serum of pregnant women throughout the duration of pregnancy (1 st , 2 nd and 3 rd trimester), a selenium depletion was concomitant with an increase of copper [8].…”

Section: Discussionsupporting

confidence: 92%

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Kiełczykowska¹,

Kopciał²,

Marzec³

et al. 2017

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction and objective. Lithium and selenium have been the subjects of extensive research for many years. Concern about the physiological action of these elements results from the application of lithium in medicine, as well as the beneficial influence of selenium supplementation in different pathological states. However, little data are available concerning their effect on the homeostasis of essential microelements in organs. Therefore, the aim of the current study was to evaluate the influence of lithium and/or selenium administration on homeostasis of iron, zinc, copper and manganese in the liver of rats. Materials and method. The experiment was carried on 24 male Wistar rats (4 groups of 6 animals) subjected to the treatment with: group I (control) -saline; group II -lithium carbonate at a dose of 2.7 mg Li/kg b.w.; group III -sodium selenite at a dose of 0.5 mg Se/kg b.w.; group IV -both lithium carbonate and sodium selenite at the doses mentioned above. Administration was performed for 6 weeks, once a day by stomach tube, in the form of water solutions. Results. The tissue content of zinc, iron and manganese showed no statistical differences among the studied groups. Zn was slightly decreased in group III vs. control and group II. Fe was insignificantly enhanced in groups II and IV vs. control. Mn in group IV was slightly increased vs. groups II and III. Cu in group III was significantly decreased vs. group IV and slightly depleted vs. groups I and II. Conclusion. With the exception of Cu in the Se-treated group, lithium and/or selenium did not affect the studied microelements' liver homeostasis in a significant way. These results may contribute to the knowledge of essential microelements homeostasis in human organisms undergoing lithium therapy, and/or selenium supplementation.

show abstract

Section: Discussionsupporting

confidence: 92%

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Kiełczykowska¹,

Kopciał²,

Marzec³

et al. 2017

J Pre Clin Clin Res.

View full text Add to dashboard Cite

show abstract

“…The elevated Cu content in the diet resulted in increased Se content in liver and kidney of rats fed the normal Se diet; interestingly, no effects were reported for low or high levels of Se in the diet. Similarly, Monedero-Prieto et al (2014) investigated the response of Se supplementation in rats on Zn, Fe, Cu, and Mn levels in liver and muscle, as well as urinary excretion of these elements (Zn, Cu, Fe, and Mn) under oxidative stress (protein deficiency). Alterations in excretion and/or tissue deposition were observed only in the case of Cu and Fe.…”

Section: Introductionmentioning

confidence: 99%

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Myška¹,

Száková²,

Fučíková³

et al. 2016

CZECH J ANIM SCI

View full text Add to dashboard Cite

ABSTRACT:The effect of selenium-enriched defatted rapeseeds (DRS) added to the diet on Se uptake by rat organisms (whole blood, liver, kidney) was investigated in model conditions. Additionally, the response of other essential trace and major mineral elements (Cu, Ca, Fe, K, Mg, Mn, P, S, and Zn) in rat organisms on selenium and/or DRS addition was assessed. The experimental diets for the individual experimental groups were prepared as follows: group DRS 0 (control diet), group DRS 30 (30% of soybean meal in the diet replaced with DRS), group DRS60 (60% of soybean meal in the diet replaced with DRS), and group DRS100 (100% of soybean meal in the diet replaced with DRS), either unenriched or naturally fortified with Se. Whereas Se content in the blood and liver of the animals remained unchanged, increased Se levels were observed in kidney of the selenized DRS100 group compared to the others. Moreover, the results showed decreasing Cd content in the rat liver with increasing Se content in the diet, confirming antagonism of these elements. Concerning the essential elements, the application of the selenized DRS did not result in any serious imbalance in the utilization of these elements. In contrast, Se addition seems to be helpful for the improved utilization of essential elements such as P, S, and Zn, compared to the DRS-containing diet without Se fortification.

show abstract

“…The activity of more than 40 intracellular enzymes [8] disrupts because of the lack of zinc in food ration.…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Characteristics and Elemental Composition of Rat Liver Under Different Nutrient Provision

E.A.¹

2016

Geomate

View full text Add to dashboard Cite

ABSTRACT:The article presents research of structural and functional changes in the liver in the conditions of modeling of micronutrient deficiencies in the organism of experimental animals with subsequent inclusion of complex minerals into their food ration. The object of the study was the liver of rats «Wistar». The elemental composition of biological substrates has been studied using atomic emission and mass spectrometry (ICP-AES and ICP-MS) in the test laboratory ANO «Center for Biotic Medicine». It has been established that the addition of selenium to the ration increases the concentration of this element in the liver by 15,0% (p≤0,05) against the background of lowering nickel by 50,0% (p≤0,05) in the experimental group I relative to control. When you turn on zinc into the ration, the concentration of it increases by 14,3% (p≤0,05) in the experimental group II relative to the control. Inclusion of iodine in the ration contributed to the increase of the iodine concentration by 4,52% in the experimental group III relative to the control group. Thus, the intake by the animal organism of toxic elements (lead and cadmium salts) leads to a change in the structural elements of the liver, resulting in depletion of hepatocyte in glycogen, or its complete disappearance, in offensive vacuolization and necrosis of hepatocytes and in changes in vessels diameter microvasculature, i.e. structural and functional changes in the liver are identified. Introduction into the ration of complex of essential trace elements (I, Se, Zn) involves an increase in functional activity of the liver.

show abstract

Effects of Selenium on Liver and Muscle Contents and Urinary Excretion of Zinc, Copper, Iron and Manganese

Cited by 8 publications

References 25 publications

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Morphofunctional Characteristics and Elemental Composition of Rat Liver Under Different Nutrient Provision

Contact Info

Product

Resources

About