“…The pleiotropic effects of SeMet have resulted in therapeutic benefits and protective effects on drug toxicities in several xenograft models [ 28 ]. However, in our phase II clinical trial [ 27 ], Se supplement decreased the incidence of acute side effects during concurrent chemoradiotherapy, but did not improve the efficacy of chemoradiotherapy in patients with cervical cancer. More clinical trials are needed in the future to determine whether Se can effectively improve the therapeutic efficacy of anticancer drug.…”