Effects of sensory overstimulation in postpartum rats

Porras, Abishag; Rodney-Hernández, Paolaenid; Nguyen, Christine; Rincón-Cortés, Millie

doi:10.1016/j.physbeh.2024.114547

Physiology & Behavior

2024

DOI: 10.1016/j.physbeh.2024.114547

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Effects of sensory overstimulation in postpartum rats

Abishag Porras,

Paolaenid Rodney-Hernández,

Christine Nguyen

et al.

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2024

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Cited by 2 publications

References 34 publications

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Effects of Early Life Scarcity‐Adversity on Maturational Milestones in Male and Female Rats

Lauraine,

Oak,

Nguyen

et al. 2024

Developmental Psychobiology

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Although many studies have shown a long‐term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex‐dependent even at an early age. In accordance, we hypothesized that early life scarcity‐adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity‐adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity‐adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex‐dependent manner.

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Effects of Early Life Scarcity‐Adversity on Maturational Milestones in Male and Female Rats

Lauraine,

Oak,

Nguyen

et al. 2024

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

Sex-dependent effects of early life sensory overstimulation on later life behavioral function in rats

Porras,

Rodney-Hernández,

Jackson

et al. 2024

Sci Rep

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Children today are immersed in electronic technology shortly after birth as they now begin regularly watching television earlier than they did in the past. Many new programs geared towards infants contain lots of lights, color, and sounds, which may constitute a form of sensory overstimulation (SOS) that leads to cognitive and behavioral changes in children and adolescents. Here, we examined the impact of early life SOS exposure on later life behavioral and cognitive function in rodents by exposing developing male and female rats to excessive audiovisual stimulation from postnatal days (PND) 10–40 and assessing anxiety-like behavior, social motivation, compulsive behavior, and spatial learning/cognition from PND 50–60. To evaluate potential SOS effects on hypothalamic–pituitary–adrenal (HPA)-axis function, levels of the stress hormone corticosterone (CORT) were measured at 3 timepoints (e.g., PND 23, 41, 61) post-SOS exposure. Sensory overstimulated males exhibited reduced anxiety-like and compulsive behavior compared to controls, whereas females exhibited reduced social motivation but enhanced spatial learning/cognition compared to controls. No differences in baseline CORT levels were found at any age tested, suggesting no impact of early life SOS on later life basal HPA-axis function. Our results demonstrate sex-specific effects of early life SOS on distinct behavioral domains in early adult rats.

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Effects of sensory overstimulation in postpartum rats

Cited by 2 publications

References 34 publications

Effects of Early Life Scarcity‐Adversity on Maturational Milestones in Male and Female Rats

Effects of Early Life Scarcity‐Adversity on Maturational Milestones in Male and Female Rats

Sex-dependent effects of early life sensory overstimulation on later life behavioral function in rats

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