Effects of sequential aeromedical evacuations following traumatic brain injury in swine

Arnaud, Françoise; Haque, LT Ashraful; Barkei, MAJ Erica; Morris, MAJ Erin; Hubbell, Jordan N.; Coschigano, Natalie; Gosztyla, LCDR Carolyn; Malone, Col Debra L.; Scultetus, Anke

doi:10.1016/j.injury.2022.09.004

Injury

2022

DOI: 10.1016/j.injury.2022.09.004

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Effects of sequential aeromedical evacuations following traumatic brain injury in swine

Françoise Arnaud

LT Ashraful Haque²,

MAJ Erica Barkei³

et al.

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2024

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Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Факторами, які впливають на стан пацієнтів, також є гіповолемія та вентиляція з позитивним тиском, які погіршують венозне повернення посилюючи артеріальну гіпотензію. Важливо, щоб нестабільні пацієнти були компенсовані перед переведенням, а вазопресори були доступні під час транспортування [3,4].…”

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Особливості Змін Показників Гемодинаміки У Постраждалих Із Мінно-Вибуховими Проникаючими Пораненнями Голови Під Час Проведення Аеромедичної Евакуації

Хитрий,

Ухач

2023

Перспективи та інновації науки

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Особливості Змін Показників Гемодинаміки У Постраждалих Із Мінно-Вибуховими Проникаючими Пораненнями Голови Під Час Проведення Аеромедичної Евакуації

Хитрий,

Ухач

2023

Перспективи та інновації науки

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Aeromedical evacuation-relevant hypobaria following traumatic brain injury in rats contributes to cerebral blood flow depression, altered neurochemistry, and increased neuroinflammation

Proctor,

Xu,

Guo

et al. 2024

J Cereb Blood Flow Metab

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Aircraft cabins are routinely pressurized to the equivalent of 8000 ft altitude. Exposure of lab animals to aeromedical evacuation relevant hypobaria after traumatic brain injury worsens neurological outcomes, which is paradoxically exacerbated by hyperoxia. This study tested the hypothesis that exposure of rats to hypobaria following cortical impact reduces cerebral blood flow, increases neuroinflammation, and alters brain neurochemistry. Rats were exposed to simulated ground (normobaric) or air (hypobaric 8000 ft) transport, under normoxia or hyperoxia, 24 hr after trauma. Hypobaria exposure resulted in lower cerebral blood flow to the contralateral cortex and bilateral thalamus during flight and increased delayed cortical inflammation (ED1 immunoreactivity) at 14 days post injury. Impacted rats exposed to hypobaria had higher cortical creatine levels compared rats maintained at sea level. Exposure to the combination of hyperoxia and hypobaria resulted in the greatest reduction in cortical blood flow and total creatine during flight which persisted up to two weeks. In conclusion, hypoperfusion during hypobaria exposure could contribute to worsening of neuroinflammation and neurochemical imbalances. The presence of excessive O2 during hypobaria results in long-term suppression of cerebral blood flow, indicating that supplemental O2 should be titrated during hypobaria to maintain normoxia.

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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma

Kapapa,

Wernheimer,

Hoffmann

et al. 2024

Cells

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Traumatic brain injury (TBI) remains one of the leading causes of death. Because of the individual nature of the trauma (brain, circumstances and forces), humans experience individual TBIs. This makes it difficult to generalise therapies. Clinical management issues such as whether intracranial pressure (ICP), cerebral perfusion pressure (CPP) or decompressive craniectomy improve patient outcome remain partly unanswered. Experimental drug approaches for the treatment of secondary brain injury (SBI) have not found clinical application. The complex, cellular and molecular pathways of SBI remain incompletely understood, and there are insufficient experimental (animal) models that reflect the pathophysiology of human TBI to develop translational therapeutic approaches. Therefore, we investigated different injury patterns after acute subdural hematoma (ASDH) as TBI in a post-hoc approach to assess the impact on SBI in a long-term, human-sized porcine TBI animal model. Post-mortem brain tissue analysis, after ASDH, bilateral ICP, CPP, cerebral oxygenation and temperature monitoring, and biomarker analysis were performed. Extracerebral, intraparenchymal–extraventricular and intraventricular blood, combined with brainstem and basal ganglia injury, influenced the experiment and its outcome. Basal ganglia injury affects the duration of the experiment. Recognition of these different injury patterns is important for translational interpretation of results in this animal model of SBI after TBI.

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Effects of sequential aeromedical evacuations following traumatic brain injury in swine

Cited by 3 publications

References 35 publications

Особливості Змін Показників Гемодинаміки У Постраждалих Із Мінно-Вибуховими Проникаючими Пораненнями Голови Під Час Проведення Аеромедичної Евакуації

Особливості Змін Показників Гемодинаміки У Постраждалих Із Мінно-Вибуховими Проникаючими Пораненнями Голови Під Час Проведення Аеромедичної Евакуації

Aeromedical evacuation-relevant hypobaria following traumatic brain injury in rats contributes to cerebral blood flow depression, altered neurochemistry, and increased neuroinflammation

Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma

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