Effects of Sequential Calcium Phosphate- Fluoride Rinses on Fluoride Uptake in Rats

Abstract

This study measured the effects of a calcium phosphate rinse followed by various fluoride rinses on fluoride uptake by enamel in rats. Calcium phosphate rinses promoted fluoride uptake by the enamel.

Effects of Flushings with an Acidic Calcium Phosphate Solution on Fluoride Binding and Caries in Rat Teeth

“…Inclusion of CPS in various fluoride re gimens increases the efficiency of fluoride uptake in this and previous investigations [Shern et al, 1979[Shern et al, , 1984b, Perhaps peri odic treatments with CPS could also aug ment the benefits accruing from extrane ous exposure to fluoride such as that avail able from the drinking water, foods, and oral hygiene products. If so, two impor tant therapeutic objectives would be achieved: keeping the fluoride in the area of its activity and increasing the effective ness of the fluoride with no increase of dosage.…”

“…No untoward effects were observed vis ually following use of the CPS solutions in this investigation or in our previously re ported animal and clinical studies [Shern et al, 1979[Shern et al, , 1984b[Shern et al, , 1986Chow et al, 1981]. These favorable responses were ex pected because both phosphoric acid and DC PD have been used safely for many years as components of foods, beverages, cosmetics and dietary mineral supple ments.…”

“…Findings from animal [Shern et al, 1979[Shern et al, , 1984b and clin ical studies [Chow et al, 1981;Shern et al, 1986] also suggest that the two-step proce dure is safe and versatile. The initial treat ment solution used in these studies was an acidic calcium phosphate solution (CPS) which was saturated with respect to dical cium phosphate dihydrate (DCPD), CaHP0 4 -2H20.…”

Apatitic Fluoride Increase in Enamel from a Topical Treatment Involving Intermediate CaHPO4·2H2O Formation, an in vivo Study

“…Since the NaF, API' and SnF2 solutions used were all concen trated enough to form CaF2 initially, it ap pears that the apatitic fluoride was formed from the reaction of CaF2 and DCPD de scribed earlier. In the studies by Shern et al [1979Shern et al [ , 1980, one group of animals received a pretreatment with DCPD followed by a rinse with distilled water. Significant fluoride uptakes were observed despite the fact that the only source of fluoride in this group was the diet (0.66 ppm F).…”

Effects of an Acidic Calcium Phosphate Solution and the Intraoral Fluoride-Releasing Device on Dental Caries and Fluoride Uptake in Rats

“…The CPS creates a surface rich in dicalcium phosphate di hydrate that binds readily with fluoride to form a fluoridc-rich apatite. CPS and fluoride solutions applied sequentially produced high levels of fluorapatite with no morphologic change in the tooth surface in vitro [Chow and Brown, 1975], in rats [Shern et al, 1979[Shern et al, , 1984a[Shern et al, , 1987Schreiber et al, 1988] and in humans [Chow et al, 1981].…”