Effects of Serotonin on Blood Glucose and Insulin Levels of Glucose- and Streptozotocin-Treated Mice

Sugimoto, Yukihiko; Kimura, Ikuko; Yamada, Jun; Watanabe, Yoshinori; Takeuchi, Naoko; Horisaka, Kazuyoshi

doi:10.1254/jjp.54.93

Cited by 41 publications

(30 citation statements)

References 14 publications

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“…Several lines of evidence suggest a role for serotonin in the regulation of energy balance, specifically in relation to glucose and fatty acid metabolism. Serotonin is known to induce hepatic regeneration (Lesurtel et al 2006), glucose secretion from the liver, and insulin secretion by the pancreas (Sugimoto et al 1990, Watanabe et al 2011 as well as liver glucose uptake mechanisms (Moore et al 2004(Moore et al , 2005 and glycogen metabolism (Papadimas et al 2012). Furthermore, serotonin has been shown to regulate glucose-stimulated insulin secretion by the b cells of the pancreas during pregnancy, and it is critical for glucosestimulated insulin secretion in an insulin-resistant state (Ohara-Imaizumi et al 2013, Kim et al 2015.…”

Section: Discussionmentioning

confidence: 99%

“…The liver expresses TPH1 and several serotonin receptor subtypes (Papadimas et al 2012). Serotonin is thought to mediate hepatic regeneration (Lesurtel et al 2006) as well as glucose and insulin secretion (Sugimoto et al 1990). Studies have shown that serotonin is involved in liver glucose uptake mechanisms (Moore et al 2005) and glycogen metabolism (Papadimas et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Laporta

Moore

Weaver

et al. 2015

Journal of Endocrinology

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A 4!4 Latin square design in which varied doses (0, 0.5, 1.0, and 1.5 mg/kg) of 5-hydroxy-L-tryptophan (5-HTP, a serotonin precursor) were intravenously infused into late-lactation, non-pregnant Holstein dairy cows was used to determine the effects of serotonin on calcium and energy metabolism. Infusion periods lasted 4 days, with a 5-day washout between periods. Cows were infused at a constant rate for 1 h each day. Blood was collected pre-and 5, 10, 30, 60, 90, and 120 min post-infusion, urine was collected pre-and post-infusion, and milk was collected daily. All of the 5-HTP doses increased systemic serotonin as compared to the 0 mg/kg dose, and the 1.0 and 1.5 mg/kg doses increased circulating glucose and non-esterified fatty acids (NEFA) and decreased beta-hydroxybutyrate (bHBA) concentrations. Treatment of cows with either 1.0 or 1.5 mg/kg 5-HTP doses decreased urine calcium elimination, and the 1.5 mg/kg dose increased milk calcium concentrations. No differences were detected in the heart rates, respiration rates, or body temperatures of the cows; however, manure scores and defecation frequency were affected. Indeed, cows that received 5-HTP defecated more, and the consistency of their manure was softer. Treatment of late-lactation dairy cows with 5-HTP improved energy metabolism, decreased loss of calcium into urine, and increased calcium secretion into milk. Further research should target the effects of increasing serotonin during the transition period to determine any benefits for post-parturient calcium and glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Laporta

Moore

Weaver

et al. 2015

Journal of Endocrinology

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“…Evidence of insulin-dependent hypoglycemic effect of serotonin (Yamada et al, 1989;Sugimoto et al, 1990), SSRIs, or monoamine oxidase inhibitors (Lundquist et al, 1971;Furman, 1974;Smith and Pogson, 1977;Wilson and Furman, 1982;Gomez et al, 2001;Pollak et al, 2001) has been provided in many previous studies. Not all of the SSRIs lowered the plasma glucose in association with the increase of plasma insulin level (Erenmemisoglu et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Serotonin enhances β-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats

Chi

Chen

et al. 2007

Life Sciences

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“…Recently, Weaver et al (2016) and Hernández-Castellano et al (2017) demonstrated that the infusion of the 5-HT precursor 5-hydroxytryptophan (5-HTP) during the last days before parturition improved blood calcium concentrations around parturition. Additionally, 5-HT has been shown to influence several metabolites related to glucose and lipid metabolism such as glucose, insulin, triglyceride, cholesterol, and fatty acid concentrations in mice (Sugimoto et al, 1990;Watanabe et al, 2010) and sheep (Watanabe et al, 2014). Moreover, 5-HT promotes the proliferation and activation of B cells in mice (Iken et al, 1995), and therefore the IgG concentration could also be affected by the increased 5-HT concentration in blood.…”

Section: Introductionmentioning

confidence: 99%

Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

Hernández-Castellano

Hernández

Sauerwein

et al. 2017

Journal of Dairy Science

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Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period. In this study, 20 Holstein dairy cows were randomly assigned to 2 experimental groups. Both groups received a daily i.v. infusion of 1 L of either 0.9% NaCl (control group; n = 10) or 0.9% NaCl containing 1 mg of 5-HTP/kg of BW (5-HTP group, n = 10). Infusions started d 10 before estimated parturition date and ended the day of parturition, resulting in a minimum of 4 d of infusion (8.4 ± 0.7 d of infusion). Until parturition, blood samples were collected before the daily infusions, and postpartum daily until d 7, and on d 30. Plasma concentrations of parathyroid hormone (PTH) were transiently increased at parturition and on d 1 in control cows. In the 5-HTP group PTH remained unchanged. The concentration of pyridinoline (PYD), an established marker for calcium release from the bone to the bloodstream, increased on d 1 postpartum only in the 5-HTP group. In control cows, PYD concentrations did not change on d 1 postpartum. Melatonin concentrations were slightly but significantly increased in the 5-HTP group compared with the control group. Insulin concentrations decreased in both groups postpartum. Before parturition, leptin concentrations decreased in both groups and remained at this level until d 30 postpartum. Plasma IgG concentrations decreased in both groups on d -1 postpartum. Haptoglobin increased in both groups on d -1 and remained at this level until d 7 postpartum. No differences between groups were observed for insulin, glucagon, IgG, leptin, adiponectin, and haptoglobin concentrations. The results obtained in the present study evidenced that 5-HT is regulating calcium homeostasis independent of PTH. The lack of treatment effects on IgG and on other hormones and metabolites indicates that 5-HTP did not affect these other metabolic pathways and the IgG concentration during the transition period.

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Effects of Serotonin on Blood Glucose and Insulin Levels of Glucose- and Streptozotocin-Treated Mice

Cited by 41 publications

References 14 publications

Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Serotonin enhances β-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats

Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

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