Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents

Hiio, Kelli; Merenäkk, Liis; Nordquist, Niklas; Parik, Jüri; Oreland, Lars; Veidebaum, Toomas; Harro, Jaanus

doi:10.1097/ypg.0b013e32834371e8

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…The 5-HTTLPR ss genotype had a negative impact on mental health after childhood abuse only in patients with the BDNF Val/Val genotype 6. A genegene interaction on conscientiousness in adolescence was found in BDNF Val66Met Met allele carriers, with participants with the 5-HTTLPR ss genotype having the lowest conscientiousness scores 32. These studies support that a 5-HTTLPR and BDNF Val66Met gene-gene interaction plays a role on the phenotypes related to mood disorders and personality.…”

Section: Discussionmentioning

confidence: 51%

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Lee

Jeong

Kim

et al. 2014

Psychiatry Investig

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ObjectiveWe investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression.MethodsFinal analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed.ResultsThe 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing.ConclusionThis result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.

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Section: Discussionmentioning

confidence: 51%

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Lee

Jeong

Kim

et al. 2014

Psychiatry Investig

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“…Nonetheless, there is evidence, albeit mixed, of potential different central nervous system characteristics between those low and high in conscientiousness, which may suggest there may be a specifically biological explanation for the observed effects. Specifically, Hiio and colleagues (Hiio et al, 2011) reported that low conscientiousness is a characteristic of carriers of the brain-derived neurotrophic factor (BDNF) Val66Met genotype Met-allele and several studies have shown that the BDNF Met allele has been associated with an impairment in extinction learning in both mice (Soliman et al, 2010; Yu et al, 2009) and humans (Soliman et al, 2010), likely because of reduced ventromedial prefrontal activity and increased amygdala activity during extinction. Importantly, Yu and colleagues documented that this extinction learning deficit exhibited by BDNF met mice can be reversed by the administration of DCS (Yu et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: Prognostic and prescriptive variables.

Smits¹,

Hofmann²,

Rosenfield³

et al. 2013

Journal of Consulting and Clinical Psychology

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Objective The aim of the current study was to identify individual characteristics that (1) predict symptom improvement with group cognitive behavioral therapy (CBT) for social anxiety disorder (SAD; i.e., prognostic variables) or (2) moderate the effects of d-cycloserine vs. placebo augmentation of CBT for SAD (i.e., prescriptive variables). Method Adults with SAD (N=169) provided Liebowitz Social Anxiety Scale (LSAS) scores in a trial evaluating DCS augmentation of group CBT. Rate of symptom improvement during therapy and posttreatment symptom severity were evaluated using multilevel modeling. As predictors of these two parameters, we selected the range of variables assessed at baseline (demographic characteristics, clinical characteristics, personality traits). Using step-wise analyses, we first identified prognostic and prescriptive variables within each of these domains and then entered these significant predictors simultaneously in one final model. Results African American ethnicity and cohabitation status were associated with greater overall rates of improvement during therapy and lower posttreatment severity. Higher initial severity was associated with a greater improvement during therapy, but also higher posttreatment severity (the greater improvement was not enough to overcome the initial higher severity). D-cycloserine augmentation was evident only among individuals low in conscientiousness and high in agreeableness. Conclusions African American ethnicity, cohabitation status, and initial severity are prognostic of favorable CBT outcomes in SAD. D-cycloserine augmentation appears particularly useful for patients low in conscientiousness and high in agreeableness. These findings can guide clinicians in making decisions about treatment strategies and can help direct research on the mechanisms of these treatments.

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“…Also epistasis effects between gene variants have to be considered, for example between the 5‐HTT , MAOA and DRD4 genes . Epistasis effects between variants of the 5‐HTT and BDNF genes have also been shown both in animal experiments (reviewed by, and in humans regarding the degree of neuroticism . For instance, Grabe et al .…”

Section: Studies On Humans With Some Focus On the Serotonergic Systemmentioning

confidence: 99%

“…[147][148][149] Epistasis effects between variants of the 5-HTT and BDNF genes have also been shown both in animal experiments (reviewed by, 150 and in humans regarding the degree of neuroticism. 151 For instance, Grabe et al 152 showed that, depending on the genotype of BDNF, which mediate neuronal plasticity, the 5-HTTLPR s allele showed either protective or risk properties with regard to depressive symptoms. Finally, a recent study of adolescents, aged between 17 and 18 years, showed that the 5-HTTLPR, MAOA-uVNTR and BDNF Val66Met genotypes interacted with each other, and with family conflict and sexual abuse to increase the likelihood of delinquency, and with a positive parent-child relationship to decrease the risk of delinquency.…”

Section: Studies On Monkeysmentioning

confidence: 99%

Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure

et al. 2017

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Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol-related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post-natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed. Special focus is put on the serotonergic system within developmental and gene-environment frameworks. The review also suggests guidelines for future studies and also summarizes some of to-be-answered questions of relevance to clinical practice. Contradictory findings and paucity of studies on the effects of exposure to low alcohol levels during foetal life for the offspring's neuropsychological development call for large prospective studies, as well as for studies including neuroimaging and multi-omics analyses to dissect the neurobiological underpinnings of alcohol exposure-related phenotypes and to identify biomarkers. Finally, it remains to be investigated whether any safe threshold of alcohol drinking during pregnancy can be identified.

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Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents

Cited by 12 publications

References 33 publications

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: Prognostic and prescriptive variables.

Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure

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