Effects of Sesamin and<i>α</i>-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats

Gu, Jian; Nonaka, Michiko; Yamada, Koji; Yoshimura, Kazunari; Takasugi, Masayuki; Ito, Yuji; Sugano, Michihiro

doi:10.1271/bbb.58.1855

Cited by 23 publications

(15 citation statements)

References 5 publications

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“…CLA significantly reduced LTC 4 production in the lung but not in the spleen. A similar tissuespecific reduction of LTC 4 was observed in rats given sesamin and α-tocopherol simultaneously, while in the spleen LTB 4 but not LTC 4 was reduced (21,22). These observations suggest a complex interaction between dietary fat and antioxidants in the LT-producing system.…”

Section: Discussionsupporting

confidence: 67%

“…However, less is known of the effect that food components exert on this process. Although several food components have been shown to reduce eicosanoid production in vitro, in most cases it is practically unsatisfactory because of the limited efficacy (21,22). The results of the present study showed that CLA effectively controlled the production of LTB 4 , LTC 4 , and PGE 2 .…”

Section: Discussionmentioning

confidence: 45%

“…LTB 4 was measured as described elsewhere (20)(21)(22). PEC (2 × 10 6 cells) were suspended in Tyrode buffer containing 5 mM calcium ionophore A23187 (Sigma Chemical Co.).…”

mentioning

confidence: 99%

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Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats

Sugano

Tsujita

Yamasaki

et al. 1998

Lipids

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218

125

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The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CLA for 3 wk, there was a trend toward a reduction in the release of leukotriene B4 (LTB4) from the exudate cells in response to the dietary CLA levels. However, CLA did not appear to affect the release of histamine. A similar dose-response pattern also was observed in splenic LTB4, lung LTC4 and serum prostaglandin E2 levels, and the differences in these indices between the control and 1.0% CLA groups were all statistically significant. The reduction by CLA of the proportions of n-6 polyunsaturated fatty acids in peritoneal exudate cells and splenic lymphocyte total lipids seems to be responsible at least in part for the reduced eicosanoid levels. Splenic levels of immunoglobulin A (IgA), IgG, and IgM increased while those of IgE decreased significantly in animals fed the 1.0% CLA diet. This was reflected in the serum levels of immunoglobulins. The levels of IgA, IgG, and IgM in mesenteric lymph node lymphocytes increased in a dose-dependent manner, while IgE was reduced in those fed the higher CLA intake. However, no differences were seen in the proportion of T-lymphocyte subsets of mesenteric lymph node. These results support the view that CLA mitigates the food-induced allergic reaction.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 45%

See 1 more Smart Citation

Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats

Sugano

Tsujita

Yamasaki

et al. 1998

Lipids

Self Cite

218

125

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“…It has also been reported that oral administration of Toc derivatives induces classspecific regulation of immunoglobulin (Ig) production, for instance, down-regulation of IgE production and up-regulation of IgA and IgG production (Gu et al, 1994Kaku et al, 1999). In addition, Toc derivatives exert an anti-allergic effect through the suppression of 4-series LT production (Gu et al, 1994;. The above studies showed that T3 exerts similar, but somewhat different immunoregulatory effects as Toc.…”

mentioning

confidence: 94%

“…It has been reported that various food components such as unsaturated fatty acids, antioxidants and dietary fibers affect the above immune functions (for review, see Yamada et al, 1999). It has also been reported that oral administration of Toc derivatives induces classspecific regulation of immunoglobulin (Ig) production, for instance, down-regulation of IgE production and up-regulation of IgA and IgG production (Gu et al, 1994Kaku et al, 1999). In addition, Toc derivatives exert an anti-allergic effect through the suppression of 4-series LT production (Gu et al, 1994;.…”

mentioning

confidence: 99%

Dietary Effect of .ALPHA.-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats.

Yamada

Okabe

Ohkura

et al. 2002

FSTR

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Eight-month-old male Sprague Dawley rats were fed diets containing ␣-tocopherol (Toc) or tocotrienol (T3) mixture (composed of 20.5% ␣-Toc, 21.4% ␣-T3, 36.5% ␥-T3 and other analogs) at the 0.1 or 0.5% level for 3 weeks to examine their dietary effects on lipid metabolism and immune indices. Feeding of ␣-Toc and T3 significantly decreased liver phosphatidylcholine peroxide and serum phospholipid levels. In the regulation of immunoglobulin level, significant increase in serum IgA level was observed in the rats fed ␣-Toc or T3, but the effect on immunoglobulin productivity from spleen and mesenteric lymph node (MLN) was not as marked. Feeding of ␣-Toc and T3 significantly decreased LTB 4 -releasing activity of peritoneal exudate cells without decreasing arachidonic acid level. The suppression of LTB 4 release was more marked in the rats fed 0.1% ␣-Toc or T3 than in these fed them at the 0.5% level. When animals were killed after 10 h of fasting, T3 was detected only in MLN and epidydimal adipose tissue. These results suggest that T3 modulates lipid metabolism and immune functions as well as ␣-Toc, and that MLN and adipose tissue are the main target tissues of T3.

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Recent topics in anti‐oxidative factors

Yamada

Tachibana

2000

BioFactors

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Lipids and anti-oxidative factors regulate immune functions such as immunoglobulin production and chemical mediator release. For example, polyunsaturated fatty acids (PUFA) enhance IgE production of isolated rat lymphocytes, but not in the presence of alpha-tocopherol. In addition, anti-oxidative factors such as tea polyphenols and flavonoids exert inhibitory effect on chemical mediator release from rat peritoneal exudate cells (PEC). Some of these immunoregulatory activities of food components could be expressed in vivo. Oral administrations of perilla and fish oils or tea polyphenols led to a significant decrease of LTB4 releasing activity of rat PEC, but IgE production enhancing activity of PUFA was not expressed in vivo. On the other hand, alpha-tocopherol feeding enhanced serum IgA level as well as IgA productivity of mesenteric lymph node lymphocytes. These results suggest that dietary fats and antioxidants are effective for the alleviation of allergic symptom and activation of immune functions.

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Effects of Sesamin andα-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats

Cited by 23 publications

References 5 publications

Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats

Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats

Dietary Effect of .ALPHA.-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats.

Recent topics in anti‐oxidative factors

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