Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnant Women and Their Infants

Yang, Hui; Hu, Bin; Zhan, Sudong; Yang, Li; Xiong, Guoping

doi:10.5858/arpa.2020-0232-sa

Cited by 38 publications

(36 citation statements)

References 20 publications

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“…Neonatal death was reported in 5 (2.0%) of 251 COVID-19 pregnancies (3 due to prematurity and 2 due to sepsis), and only one (0.4%) of 251 live-born newborns was RT-PCR positive after birth [10]. In the study conducted by Zhu et al, one of the babies of nine COVID-19 positive mothers died, while five were hospitalized in the neonatal intensive care unit [25]. In their study, Yang et al reported neonatal death in only 1.2% [11].…”

Section: Discussionmentioning

confidence: 99%

Clinical findings, treatments and obstetric results of pregnant women diagnosed with coronavirus disease 2019

Elçi¹,

Çakmak²,

Elçi³

et al. 2021

Journal of Surgery and Medicine

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Background/Aim: Coronavirus disease 2019 , which causes acute respiratory disease, is an emergency that concerns global public health. Limited data are available on coronavirus disease 2019 in pregnant women. We aimed to evaluate the characteristic features and perinatal results of pregnant women diagnosed with COVID-19. Methods: This retrospective cohort study was conducted in a Training and Research Hospital. Clinical records and perinatal results of 84 pregnant women and 46 newborns diagnosed with coronavirus disease 2019 in a pandemic hospital on the Asian side of Istanbul between March 29-June 30, 2020, were retrospectively analyzed. Results: The mean maternal age of the patients was 28.8 (5.6) (17-43) years. The most common symptoms were cough (41.7%), shortness of breath (26.2%), fever (19%), myalgia and malaise (19%). Fifteen percent of patients were in the first trimester, 20.2% were in the second and 64.3% were in the third trimester. Sixtytwo percent of the pregnant women were PCR positive and 38.1% had clinical or radiological findings. CT was performed in 27 patients, and lung findings were observed in 23. Among all, 29.8% of the patients received inpatient treatment and 70.2% received outpatient treatment or follow-up. Medical treatment was given to 42.9% of the patients. Sixty percent of the hospitalized pregnant women were admitted to the adult intensive care unit and 3.6% (3/84) resulted in maternal death. Thirteen newborns (28.2%) were admitted to the neonatal intensive care unit. Fever was seen in 6.5% (3/46), dyspnea, in 15.2% (7/46), and pneumonia, in 13% (6/46) of the hospitalized newborns. PCR was performed only in newborns admitted to the neonatal unit. All neonatal PCR tests were negative. Death due to sepsis was seen in 3 newborns. Conclusion: COVID-19 can cause preterm labor in pregnant women. Lymphocyte, thrombocyte, and CRP values may be useful in clinical follow-up and treatment. PCR positivity decrease and CT findings increase with clinical severity.

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Section: Discussionmentioning

confidence: 99%

Clinical findings, treatments and obstetric results of pregnant women diagnosed with coronavirus disease 2019

Elçi¹,

Çakmak²,

Elçi³

et al. 2021

Journal of Surgery and Medicine

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show abstract

“…With reference to the laboratory findings, in our study, 15.7% of the pregnant patients had lymphopenia, and elevated ALT and AST were observed in 24.2% and 11.2% of the patients, respectively, and 10% had elevated D-dimer. Several studies have reported lymphopenia in both the general population affected by COVID-19 [36] and also in pregnant women affected by COVID-19 [17, 37]. Similarly, a retrospective study found the likelihood of lymphopenia as well as increased concentrations of ALT or AST as one of the clinical manifestations [13].…”

Section: Discussionmentioning

confidence: 99%

Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait

Ayed

Embaireeg

Benawadth³

et al. 2020

Preprint

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Background: In late December of 2019, a novel coronavirus (SARS-CoV-2) was identified in the Chinese city Wuhan among a cluster of pneumonia patients. While it is known that pregnant women have reduced immunity and they are at risk for COVID-19 infection during the current pandemic, it is not clear if the disease manifestation would be different in pregnant women from non-pregnant women. Objectives: To describe the maternal and neonatal clinical features as well as outcome of pregnancies complicated with SARS-CoV-2 infection. Methods: In this retrospective national-based study, we analyzed the medical records of all SARS-CoV-2 positive pregnant patients and their neonates who were admitted to New-Jahra Hospital, Kuwait, between March 15th 2020 and May 31st 2020. The outcomes of pregnancies were assessed until the end date of follow-up (June 15th 2020). Results: A total of 185 pregnant women were enrolled with a median age of 31 years (interquartile range, IQR: 27.5-34), and median gestational age at diagnosis was 29 weeks (IQR: 18-34). The majority (88%) of the patients had mild symptoms, with fever (58%) being the most common presenting symptom followed by cough (50.6%). During the study period, 141 (76.2%) patients continued their pregnancy, 3 (1.6%) had a miscarriage, 1 (0.5%) had intrauterine fetal death and only 2 (1.1%) patients developed severe pneumonia and required intensive care. Most of the neonates were asymptomatic, and only 2 (5%) of them tested positive on day 5 by nasopharyngeal swab testing. Conclusion: Pregnant women do not appear to be at higher risk to the COVID-19 than the general population. The clinical features of pregnant women with SARS-CoV-2 infection were similar to those of the general population having SARS-CoV-2 infection. Favorable maternal and neonatal outcomes reinforce the existing evidence and may guide healthcare professionals in the management of pregnancies complicated with SARS-CoV-2 infection.

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“…disease with the majority of cases occurring in the late second and third trimesters. 10,31,[44][45][46]49,60,[84][85][86][87][88][89][90] Little data are available on the effects of infection occurring in the first or early second trimesters.…”

Section: Maternal Mortalitymentioning

confidence: 99%

COVID‐19‐related disease severity in pregnancy

Thompson

Nguyen

Noble

et al. 2020

American J Rep Immunol

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The pandemic caused by COVID-19 is affecting populations and healthcare systems worldwide. As we gain experience managing COVID-19, more data become available on disease severity, course, and treatment in patients infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, data in pregnancy remain limited. This narrative review of COVID-19 during pregnancy underscores key knowledge gaps in our understanding of the impact of this viral infection on reproductive health. Current data suggest that pregnant people have similar disease course and outcomes compared to nonpregnant people, with the majority experiencing mild disease; however, pregnant people may have increased risk of hospitalization and intensive care unit (ICU) admission. Among patients who develop severe and critical disease, major maternal morbidity and mortality have been described including cardiomyopathy, mechanical ventilation, extracorporeal membrane oxygenation, and death. Many questions remain regarding maternal severity of disease in COVID-19. Further research is needed to better understand disease course in pregnancy. Additionally, the inclusion of pregnant patients in therapeutic trials will provide vital data on treatment options for patients. As we continue to treat more patients affected by SARS-CoV-2, multidisciplinary care and continued research are both needed to achieve optimal outcomes for mother and fetus.

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Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnant Women and Their Infants

Cited by 38 publications

References 20 publications

Clinical findings, treatments and obstetric results of pregnant women diagnosed with coronavirus disease 2019

Clinical findings, treatments and obstetric results of pregnant women diagnosed with coronavirus disease 2019

Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait

COVID‐19‐related disease severity in pregnancy

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