Effects of Sevoflurane and Isoflurane on Cardiac and Coronary Dynamics in Chronically Instrumented Dogs

Bernard, Jean-Marc; Wouters, Patrick; Doursout, Marie–Françoise; Florence, B.; Chelly, Jacques E.; Merin, Robert G.

doi:10.1097/00000542-199004000-00014

Cited by 199 publications

(117 citation statements)

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“…Further study is needed using more sophisticated methodology, such as echocardiography, or by assessing more load-independent indices of contractility. 4 In summary, sevoflurane plus N20 increased cardiac filling pressures, a finding which was not consistent with the volunteer study, 1 whereas isoflurane plus N20 did not. Whether these effects of N20 were ascribable to surgical stimulation is uncertain.…”

Section: Discussionmentioning

confidence: 66%

Haemodynamic comparison of sevoflurane and isoflurane anaesthesia in surgical patients

Inada

Kawachi

et al. 1997

Can J Anaesth

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Purpose:To compare the haemodynamic responses to surgical incision during sevoflurane and isoflurane anaesthesia and to compare the haemodynamic effects of each anaesthetic alone with those obtained using an equipotent mixture of each anaesthetic plus N20 during steady-state surgical stimulation. Methods: Twenty-four patients undergoing gastrectomy were randomized to receive sevoflurane (n --12) or isoflurane (n = 12). At 1.5 MAC, haemodynamic measurements were performed before and after surgical incision. During intestinal anastomosis, patients in each group were given (in random order) either 1.5 MAC of the designated anaesthetic or 0.85 MAC of the volatile plus 0.65 MAC N20. Haemodynamic measurements were repeated under each condition. R~.sults: One patient in the sevoflurane group and two in the isoflurane group were excluded from the incision study because of hypotension. In both groups, incision increased the heart rate (HR), mean arterial pressure, mean pulmonary arterial pressure (MPAP), pulmonary capillary wedge pressure (PC~), cardiac index, and systemic vascular resistance index (SVRI). There were no intergroup differences in the effects of incision. Inclusion of N20 resulted in an increase of NPAP (P <0.05) in both groups, an increase of central venous pressure and PCVVP in the sevoflurane group (P < 0.005), and a decrease of I-IR (P <0.005) and an increase of SVRI (P <0.05) in the isoflurane group. There were no intergroup differences in the effects of N20. Conclusions: At 1.5 MAC, sevoflurane and isoflurane do not prevent the haemodynamic response to incision. The haemodynamic effects of each volatile anaesthetic with N20 are minimal compared with those of equi-lAC volatile alone.Objcctifs : Comparer les rEponses hEmodynamiques ~ I'incision chirurgicale pendant I'anesthEsie au --~votiurane et ~ risoflurane; comparer les effets hEmodynamiques de chacun de ces anesthEsiques seuls avec ceux d'un melange 6quipotent de chacun associ6 au N20 pendant une stimulation chirurgicale une fois rEtat d'Equilibre atteint. MEthodes : Vingt-quatre patients subissant une gastrectomie Etaient rEpartis alEatoirement pour recevoir du sEvoflurane (n = 12) ou de I'isoflurane (n= 12). ik 1,5 MAC, les mesures hEmodynamiques Etaient effectuEes avant et aprEs I'incision, Pendant I'anastomose intestinale, les patients de chaque groupe recevaient (de fagon alEatoire) soit 1,5 MAC de I'agent dEsign6 ou 0,85 MAC de I'agent volatile plus 0,65 MAC de N20. Les mesures hEmodynamique Etaient alors rEpEtEes, I~.sultats : Un patient du groupe sEvoflurane et deux patients du groupe isoflurane ont EtE exclus parce qu'ils Etaient hypotendus au moment de I'incision. Dans les deux groupes, rincision a provoclu4 une accElEration de la frEquence cardiaque (FC), une augmentation de la pression artErielle moyenne, de la pression art6rielle pulmonaire moyenne (PAPN), de la pression capillaire bloquEe (PCB), de I'index cardiaque et de la resistance vasculaire systEmique indexEe (RVSI), II n'y avait pas de differences entre les groupes en ce qui c...

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Section: Discussionmentioning

confidence: 66%

Haemodynamic comparison of sevoflurane and isoflurane anaesthesia in surgical patients

Inada

Kawachi

et al. 1997

Can J Anaesth

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“…24 Sevoflurane has been demonstrated to induce few changes in heart rate in patients concomitantly administered sevoflurane and fentanyl during CABG, 21,28 in healthy human volunteers or when 0.4 to 1.5 MAC sevoflurane was administered to animals. 31,32 Hemodynamics Cardiac index did not differ between the awake and anesthetized states; furthermore, cardiac index did not differ between the two groups before bypass. This may be attributed to maintenance of similar loading conditions (preload, systemic vascular resistance) before and after induction of anesthesia in each group and secondly, the low concentrations of inhaled anesthetic agent causing minimal myocardial depression.…”

Section: Heart Ratementioning

confidence: 89%

“…31,[34][35][36][37] Because of their negative inotropic effects, both halothane and sevoflurane reduce myocardial oxygen demand in a dose dependent manner. 34 These reductions in demand would be expected to lead to decreases in coronary blood flow.…”

Section: Myocardial Ischemiamentioning

confidence: 99%

Sevoflurane or halothane with target-controlled sufentanil infusions for coronary artery bypass surgery

Levin

Coetzee

Coetzer³

et al. 2007

Southern African Journal of Anaesthesia and Analgesia

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ObjectivesComparison of hemodynamics, circulatory efficiency, myocardial ischemia and recall during and after sevoflurane or halothane (0.6 MAC {Minimum Alveolar Concentration} inspired) combined with a target-controlled sufentanil infusion (2 ng.ml -1 ) for coronary artery bypass grafting. MethodsProspective randomised non-blinded study in a university teaching hospital of 45 patients undergoing on-pump surgery. Inhalation anesthetic agent was delivered before, during and after cardiopulmonary bypass. ResultsIntraoperative hemodynamics were maintained within predetermined limits using vasoactive and cardioactive drugs. Heart rate was unchanged from baseline, however the sevoflurane-sufentanil group required more glycopyrrollate, indicating a tendency towards a slower heart rate. In both groups, similar low incidences of myocardial ischemia were detected. After induction of anesthesia, as well as intraoperatively, oxygen consumption decreased by up to 36.6% compared with the awake values in both groups. Oxygen delivery remained unchanged during all measuring periods. Mixed venous oxygen tensions rose after induction, even in patients with cardiac indices below 2.2 L.min -1 .m -2 , indicating maintenance of an effective circulation when utilising these techniques. Twelve hours postoperatively, oxygen consumption exceeded awake values by 31%. No explicit recall was reported by any patient on enquiry on the third postoperative day. ConclusionsLow concentrations of sevoflurane or halothane, supplementing target-controlled sufentanil infusions, were both suitable for providing anesthesia for coronary bypass surgery.

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“…A decrease in blood pressure, cardiac output and systemic vascular resistance can cause an increase in HR due to baroreceptor reflex (Stoelting, 1999). Several studies indicated an increase in heart rate in dogs (Bernard et al, 1990;Ebert et al, 1995;Mutoh et al, 1997) whereas heart rate remained unchanged in humans, sheep and goats (Ebert et al, 1995;Hikasa et al, 1998; during sevoflurane anesthesia. In dogs, it has been suggested that the differences in vagolytic activity of the inhalation anesthetics is responsible for the increase in HR observed (Steffey and Mama, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…An increase in heart rate has been reported in dogs (Bernard et al, 1990;Ebert et al, 1995;Mutoh et al, 1997) whereas it remained unchanged in humans, sheep and goats (Ebert et al, 1995;Hikasa et al, 1998; during sevoflurane anesthesia. At 1 Minimum Alveolar Concentration (MAC), both sevoflurane and isoflurane cause a dose dependent decrease in respiratory rate and an increase in end-tidal partial pressures of carbon dioxide (PETCO2) in dogs, sheep and goats (Galloway et al, 2004;Hikasa et al, 1998;Johnson et al, 1998;Mutoh et al, 1997).…”

Section: Introductionmentioning

confidence: 96%

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Sellers

Lin

Chamorro

et al. 2013

American Journal of Animal and Veterinary Sciences

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Isoflurane and sevoflurane are the two most commonly used inhalation anesthetics in veterinary medicine today. This study compared the anesthetic effects between isoflurane and sevoflurane in 17 calves undergoing surgery for placement of portal and jugular vein cannulas. Using a randomized control trial, calves were assigned to receive sevoflurane or isoflurane. Anesthesia was induced with xylazine and ketamine then maintained with the assigned inhalation anesthetic. Parameters for heart rate, respiratory rate, indirect blood pressures, oxygen hemoglobin saturation and end-tidal carbon dioxide were monitored and recorded during surgery. The anesthetic concentrations of the vaporizers were adjusted according to the calves' responses, e.g., blood pressure, eye position, respiratory and heart rate, to surgical stimulation. Upon discontinuation of the inhalation anesthetic, calves were placed in sternal recumbency and recovery variables including time to extubation, time to first movement, attempts to stand and time to standing were observed and recorded. Statistical analysis was performed using a two-sample t-test on the recorded variables. There were no statistical differences between isoflurane and sevoflurane for any of the parameters recorded during anesthetic maintenance or recovery. The results of this study showed a faster time to first movement and extubation, 3.38±1.85 min and 11.75±3.73 min for sevoflurane compared to 7.56±5.34 min and 15.56±8.69 min for isoflurane, respectively. Attempts to stand were 3.00±2.14 for sevoflurane and 3.22±1.79 for isoflurane. Though the time to standing during recovery was not statistically different between anesthetics, the values did indicate a quicker trend of recovery from sevoflurane. Both inhalation anesthetics produced comparable anesthetic qualities and there were no statistical differences between the parameters recorded during maintenance of anesthesia. On the basis of the reported results, sevoflurane and isoflurane are suitable inhalation anesthetics for use in calves. However, present cost of sevoflurane is a limiting factor for its use in food animals.

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Effects of Sevoflurane and Isoflurane on Cardiac and Coronary Dynamics in Chronically Instrumented Dogs

Cited by 199 publications

References 0 publications

Haemodynamic comparison of sevoflurane and isoflurane anaesthesia in surgical patients

Haemodynamic comparison of sevoflurane and isoflurane anaesthesia in surgical patients

Sevoflurane or halothane with target-controlled sufentanil infusions for coronary artery bypass surgery

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

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