Effects of Sevoflurane on Cerebral Circulation and Metabolism in Patients with Ischemic Cerebrovascular Disease

Kitaguchi, Katsuyasu; Ohsumi, Hisatoshi; Kuro, Masakazu; Nakajima, Toshito; Hayashi, Yukio

doi:10.1097/00000542-199310000-00011

Cited by 121 publications

(39 citation statements)

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“…Although Mielck et al [25] and Kitaguchi et al [26] showed no effect of 1 MAC sevofl urane on CO 2 reactivity, it is still possible that sevofl urane had some effects on CO 2 reactivity in the patients on insulin therapy in our study.…”

Section: Study Limitationscontrasting

confidence: 63%

Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia

Kikuchi

Goto

2007

J Anesth

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Section: Study Limitationscontrasting

confidence: 63%

Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia

Kikuchi

Goto

2007

J Anesth

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“…Since the differences in MAP between normocapnia and hypocapnia were small, the decline in CBF on hyperventilation indicates that none of the agents abolished CO 2 -reactivity at either MAC level although hypocapnia was induced after the intended steady-state concentration of inhalational agent had been achieved. In previous studies, sevoflurane (20,21) and desflurane (22) have both been reported not to abolish cerebral vasoreactivity to hypocapnia. Sevoflurane has also been found to resemble isoflurane with respect to dose-dependent impairment of hypocapnia-induced cerebral vasoconstriction in vitro (7).…”

Section: Cerebral Vasoreactivity To Hypocapniamentioning

confidence: 89%

Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs

Holmström¹,

Rosén

Åkeson³

2004

Acta Anaesthesiol Scand

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Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs. Link to publication Citation for published version (APA): Holmström, A., Rosén, I., & Åkeson, J. (2004). Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs. Acta Anaesthesiologica Scandinavica, 48(4), 400-404. DOI: 10.1111400-404. DOI: 10. /j.0001-5172.2004 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Background: In clinical neuroanaesthesia, the increase in cerebral blood flow (CBF) and intracranial pressure caused by the cerebral vasodilative effects of an inhalational anaesthetic agent is counteracted by the cerebral vasoconstriction induced by hypocapnia. Desflurane and sevoflurane may have advantages over the more traditionally used isoflurane in neuroanaesthesia but their dose-dependent vasodilative effects at hypocapnia have not been compared in the same model using truly equipotent minimal alveolar concentrations (MACs). Method: Desflurane, sevoflurane and isoflurane were administered in a randomized order to six pigs at 0.5 and 1.0 MAC. The intra-arterial xenon clearance technique was used to calculate CBF. Blood pressure was invasively monitored. Cerebral and systemic physiological variables were recorded first at normocapnia (PaCO 2 5.6 kPa) and then at hypocapnia (PaCO 2 3.5 kPa). Electroencephalographic (EEG) activity was continuously recorded. Results: None of the three agents abolished cerebrovascular reactivity to hyperventilation, and at 0.5 MAC all had similar

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“…In humans sevoflurane concentrations 1.5 MAC did not affect static cerebrovascular autoregulation. [20][21][22] However, studies in rats have shown that higher concentrations of sevoflurane (2.0 MAC) impair static cerebrovascular autoregulation in a fashion similar to other volatile anesthetics. 23 The dynamic component of cerebrovascular autoregulatory response, which appears to be a more sensitive indicator of altered physiology than the static component, was intact with 1.5 MAC sevoflurane, 24 but delayed with 2.0 MAC sevoflurane during the present investigation.…”

Section: Discussionmentioning

confidence: 99%

S(+)-ketamine/propofol maintain dynamic cerebrovascular autoregulation in humans

Engelhard

Werner

Möllenberg

et al. 2001

Can J Anesth/J Can Anesth

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Effects of Sevoflurane on Cerebral Circulation and Metabolism in Patients with Ischemic Cerebrovascular Disease

Cited by 121 publications

References 0 publications

Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia

Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia

Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs

S(+)-ketamine/propofol maintain dynamic cerebrovascular autoregulation in humans

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