Effects of sevoflurane on intracranial pressure, cerebral blood flow and cerebral metabolism: A dose‐response study in patients subjected to craniotomy for cerebral tumours

Bundgaard, Henning; Öettingen, Gorm von; Larsen, K. Kyllesbech; Landsfeldt, U.; Jensen, Katrine; Nielsen, Eva Amalie; Cold, Georg E.

doi:10.1111/j.1399-6576.1998.tb05292.x

Cited by 92 publications

(38 citation statements)

References 38 publications

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“…Four studies assessed CVR-CO 2 on the ipsilateral side of the cerebral pathology and found that reactivity was preserved during sevoflurane, isoflurane, and desflurane anesthesia. 36,38,40 One study found no differences in CVR-CO 2 between the normal and abnormal hemispheres in patients with brain tumors with isoflurane (1 MAC) or propofol (4 mg/kg/h) anesthesia. 41 Another study found that CVR-CO 2 was maintained in both the normal and abnormal hemisphere in patients undergoing AVM resection under isoflurane anesthesia.…”

Section: Intracranial Pathologymentioning

confidence: 98%

See 1 more Smart Citation

Cerebrovascular Reactivity to Carbon Dioxide Under Anesthesia

Mariappan

Mehta²,

Chui³

et al. 2015

Journal of Neurosurgical Anesthesiology

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Section: Intracranial Pathologymentioning

confidence: 98%

“…Six studies assessed the CVR-CO 2 in patients undergoing craniotomy for tumor removal 36,[38][39][40] or arteriovenous malformation (AVM) resection. 37 The CVR-CO 2 testing was performed after induction of anesthesia, before surgical incision.…”

Section: Intracranial Pathologymentioning

confidence: 99%

Cerebrovascular Reactivity to Carbon Dioxide Under Anesthesia

Mariappan

Mehta²,

Chui³

et al. 2015

Journal of Neurosurgical Anesthesiology

View full text Add to dashboard Cite

show abstract

“…Although inhalational agents do result in cerebral vasodilatation and are therefore likely to increase intracranial pressure, this is only a significant problem if the fraction of volatile agent used is high (i.e. > 1 MAC approx) [13][14][15]. Finally, the vast majority of respondents (90%) do not know that a rapid increase in the concentration of desflurane may be associated with sympathetic stimulation and hypertension [16].…”

Section: Discussionmentioning

confidence: 94%

Use of volatile anaesthetic agents in anaesthesia: A survey of practice in France in 2012

Benhamou

Constant

Longrois

et al. 2015

Anaesthesia Critical Care & Pain Medicine

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“…On the negative side, although several studies have shown that isoflurane does not alter ICP, Talke et al found that 0.5-1 MAC sevoflurane significantly increased cerebrospinal fluid (CSF) pressure in normocapnic patients who had no mass effect (19)(20)(21).…”

Section: Effects Of Sevoflurane and Isoflurane On Brain Injury 115mentioning

confidence: 98%

The Effects of Sevoflurane and Isoflurane on Intracranial Pressure and Cerebral Perfusion Pressure After Diffuse Brain Injury in Rats

Gören¹,

Kahveci²,

Alkan³

et al. 2001

Journal of Neurosurgical Anesthesiology

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Twenty-four adult male Wistar rats, weighing 220 to 290 g, were anesthetized with 30 mg/kg intraperitoneal sodium thiopental, then underwent a tracheostomy. After diffuse impact-acceleration brain injury (BI) was induced, each rat was paralyzed and mechanically ventilated with 30% O2 in nitrous oxide (N2O). The rats were assigned randomly to two groups, each of which received one of the two volatile anesthetic agents, sevoflurane or isoflurane. The anesthetics were administered at 0.5, 0.75, 1.0, and 1.25 minimal alveolar concentration (MAC) for 30 minutes each, respectively, and anesthesia was maintained at 0.75 MAC during the last hour of the study period. Intracranial pressure (ICP), mean arterial pressure (MAP), rectal and intrahemispheric temperatures, and end-tidal volatile anesthetic concentrations were monitored continuously throughout the 3 hours, with measurements recorded every 15 minutes. At baseline, there were no significant differences between the two groups regarding the monitored physiologic values. In the sevoflurane group, MAP fell significantly after 45 minutes, and a similar change was observed in the isoflurane group after 30 minutes (P < .05, P < .01, and P < .001, respectively). Intracranial pressure increased significantly at 45 minutes in the sevoflurane group (P < .01) and remained elevated from 60 minutes until the end of the study period (P < .01, P < .001). Although ICP increased in the isoflurane group, the change was not significant. Cerebral perfusion pressure (CPP) decreased in parallel with MAP, with the reduction in the sevoflurane group being more pronounced than that in the isoflurane group. The results demonstrated that, under the conditions of diffuse BI, animals that were anesthetized with sevoflurane had higher ICP and lower CPP levels than those anesthetized with isoflurane.

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Effects of sevoflurane on intracranial pressure, cerebral blood flow and cerebral metabolism: A dose‐response study in patients subjected to craniotomy for cerebral tumours

Abstract: Sevoflurane is a cerebral vasodilator in patients with cerebral tumours. Sevoflurane increases CBF and decreases CVR in a dose-dependent manner. CO2-reactivity is preserved during 1.5% and 2.5% sevoflurane.

Cited by 92 publications

References 38 publications

Cerebrovascular Reactivity to Carbon Dioxide Under Anesthesia

Cerebrovascular Reactivity to Carbon Dioxide Under Anesthesia

Use of volatile anaesthetic agents in anaesthesia: A survey of practice in France in 2012

The Effects of Sevoflurane and Isoflurane on Intracranial Pressure and Cerebral Perfusion Pressure After Diffuse Brain Injury in Rats

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