Effects of sevoflurane on NF-кB and TNF-α expression in renal ischemia–reperfusion diabetic rats

Zhang, Yu; Hu, Fang; Wen, Jianghua; Wei, Xiao‐Hong; Zeng, Yanjun; Sun, Ying; Luo, Shunkui; Sun, Longhao

doi:10.1007/s00011-017-1071-1

Cited by 21 publications

(16 citation statements)

References 40 publications

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“…This was usually accompanied by the release of inflammatory cytokines, such as TNF-α, IL-1β and IL-6. Studies 4 , 24 showed that the inflammatory response induced by I/R injury was further exacerbated in diabetic rats, in which TNF-a and IL-1β levels in serum or renal tissues increased significantly. In this study, we have demonstrated that administration of resveratrol proved to be effective to inhibit the expression of the pro-inflammatory cytokines TNF-α and IL-1β elevated in the kidney of diabetic rats after I/R injury.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats

Wang

Chen

et al. 2020

Acta Cir. Bras.

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Purpose To examine effects of resveratrol on renal ischemia/ reperfusion injury (I/R) in a streptozotocin (STZ)-induced diabetic rat model. Methods Twenty-four male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: Sham group, I/R group and Resveratrol group (n=8). Resveratrol (RSV) was administered at a dose of 10 mg.kg-1.d-1 fourteen days prior to suffering from I/R. Renal function, histology, SOD, MDA, TUNEL assay and expression of TNF-α, IL-1β, NF-κB-P65, COX-2 and Caspase3, Bcl2 and Bax were analyzed. Results Administration of RSV significantly reduced the serum levels of renal dysfunction and injury markers, including creatinine, blood urea nitrogen and MDA; in the other hand, it significantly increased the serum levels of SOD. The protective effect of RSV was also reflected on histologic evaluation. RSV reduced the number of apoptotic cells as determined by TUNEL assay. RSV significantly reduced the protein expression of TNF-α, IL-1β, NF-κB-P65, COX-2 and Caspase3, and Bax. Meanwhile, RSV significantly increased the protein expression of Bcl2. Conclusion RSV attenuated I/R-induced renal injury in diabetic rats through the modulation of oxidative stress and TNF-α-stimulated inflammation.

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Section: Discussionmentioning

confidence: 99%

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats

Wang

Chen

et al. 2020

Acta Cir. Bras.

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“…Previous studies have reported that the accumulation of ROS plays a significant role in I/R-induced kidney injury in diabetic patients (34). a previous study reported increased levels of BUN, serum creatinine and proinflammatory cytokines in diabetic rats that had experienced i/r injury (6). in the present study, it was observed that diabetes aggravated renal i/r injury through acute tubular damage and exacerbated kidney dysfunction; these effects were reflected by the higher levels of Bun and serum creatinine.…”

Section: Discussionmentioning

confidence: 97%

“…evidence has accumulated supporting the fact that dM aggravates renal i/r injury (5). experimental studies have revealed that diabetic rats develop renal dysfunction faster following ir injury compared with non-diabetic rats (6,7). other research has revealed that progressive hyperglycemia can cause increased levels of reactive oxygen species (roS) in the diabetic kidney following i/r injury (8).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats

et al. 2019

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The aim of the present study was to investigate whether the diabetic kidney is more susceptible to ischemia/reperfusion (i/r) injury, and identify the potential mechanisms involved. an animal model of type 1 diabetes was created by treating rats with streptozotocin (STZ). This model was then used, along with healthy controls, to investigate the effect of diabetes mellitus (dM) on renal i/r injury. after 45 min of ischemia and 24 h of reperfusion, kidney and serum samples were acquired and used to evaluate function and histopathological injury in the kidneys. Western blotting was also used to determine the expression levels of key proteins. rats experiencing renal i/R exhibited significant characteristics of renal dysfunction, reduced levels of Sirtuin 1 (SirT1) protein (a key signaling protein in the kidneys), increased endoplasmic reticulum stress (erS) and pyroptosis. Furthermore, diabetic rats exhibited further reductions in the levels of SirT1 in response to renal i/r injury and an increase in the levels of erS. These effects were all alleviated by the administration of a SirT1 agonist. The present analysis revealed that the SirT1-mediated activation of er stress and pyroptosis played a pivotal role in diabetic rats subjected to renal i/r injury. downregulation of the SirT1 signaling pathway were exacerbated in response to renal i/r injury-induced acute kidney injury (aKi). The present data indicated that dM enhanced er stress and increased pyroptosis by downregulating the SirT1 signaling pathway.

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“…The inflammatory response is another important part of the pathophysiology implicated in kidney I/R injury [38] . Some proinflammatory cytokines such as IL-2, IL-6, TNF-α and IL-1β are released during kidney I/R injury [39,40] .…”

Section: Discussionmentioning

confidence: 99%

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

Güler¹,

Tanyeli²,

Eraslan³

et al. 2019

Kafkas Univ Vet Fak Derg

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The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion. ÖzBu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

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Effects of sevoflurane on NF-кB and TNF-α expression in renal ischemia–reperfusion diabetic rats

Abstract: Sevoflurane exerted a protective effect against renal injury by lowering the expression of NF-кB and TNF-α in renal I/R diabetic rats.

Cited by 21 publications

References 40 publications

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats

Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

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