Effects of sevoflurane on respiratory rhythm oscillators in the medulla oblongata

Takita, Kensuke; Morimoto, Yuji

doi:10.1016/j.resp.2010.06.016

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…In contrast, barbiturates, such as sodium pentobarbital, decrease respiratory burst frequency, suggesting that rhythm-generating neurons are altered (Tarasiuk et al , 1991; Fregosi et al , 2004). Brainstem-spinal cord preparations are also used to examine the effects of different anesthetic drugs on brainstem respiratory neuron function, such as propofol (Kashiwagi et al , 2004), enflurane, halothane, and isoflurane (Otsuka 1998), and sevoflurane (Takita and Morimoto, 2010). The results with sevoflurane are particularly interesting because sevoflurane (at a specific concentration) inhibits pre-I neurons within the pFRG with minimal effects on other brainstem respiratory neurons, which may permit testing whether pre-I neurons are necessary for rhythm generation (Takita and Morimoto, 2010).…”

Section: Brainstem-spinal Cord Preparations Permit Rapid Screeningmentioning

confidence: 99%

“…Brainstem-spinal cord preparations are also used to examine the effects of different anesthetic drugs on brainstem respiratory neuron function, such as propofol (Kashiwagi et al , 2004), enflurane, halothane, and isoflurane (Otsuka 1998), and sevoflurane (Takita and Morimoto, 2010). The results with sevoflurane are particularly interesting because sevoflurane (at a specific concentration) inhibits pre-I neurons within the pFRG with minimal effects on other brainstem respiratory neurons, which may permit testing whether pre-I neurons are necessary for rhythm generation (Takita and Morimoto, 2010). Each drug appears to alter specific components of the brainstem respiratory control network and does not simply cause a global depression within the entire network.…”

Section: Brainstem-spinal Cord Preparations Permit Rapid Screeningmentioning

confidence: 99%

See 1 more Smart Citation

Isolated in vitro brainstem–spinal cord preparations remain important tools in respiratory neurobiology

Johnson¹,

Turner²,

Huxtable³

et al. 2012

Respiratory Physiology & Neurobiology

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Isolated in vitro brainstem-spinal cord preparations are used extensively in respiratory neurobiology because the respiratory network in the pons and medulla is intact, monosynaptic descending inputs to spinal motoneurons can be activated, brainstem and spinal cord tissue can be bathed with different solutions, and the responses of cervical, thoracic, and lumbar spinal motoneurons to experimental perturbations can be compared. The caveats and limitations of in vitro brainstem-spinal cord preparations are well-documented. However, isolated brainstem-spinal cords are still valuable experimental preparations that can be used to study neuronal connectivity within the brainstem, development of motor networks with lethal genetic mutations, deleterious effects of pathological drugs and conditions, respiratory spinal motor plasticity, and interactions with other motor behaviors. Our goal is to show how isolated brainstem-spinal cord preparations still have a lot to offer scientifically and experimentally to address questions within and outside the field of respiratory neurobiology.

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Section: Brainstem-spinal Cord Preparations Permit Rapid Screeningmentioning

confidence: 99%

Section: Brainstem-spinal Cord Preparations Permit Rapid Screeningmentioning

confidence: 99%

Isolated in vitro brainstem–spinal cord preparations remain important tools in respiratory neurobiology

Johnson¹,

Turner²,

Huxtable³

et al. 2012

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

show abstract

“…One possible explanation would be that sevoflurane can facilitate the activity of excitatory neurons within a spatially distributed brainstem network and thereby increase inspiratory drive. Indeed, Takita and Morimoto ( 2010 ) showed that in an in vitro newborn rat brainstem‐spinal cord preparation, sevoflurane has a hidden stimulant effect on the respiratory rhythm oscillators.…”

Section: Discussionmentioning

confidence: 99%

Changes in breathing pattern during severe hypothermia and autoresuscitation from hypothermic respiratory arrest in anesthetized mice

et al. 2021

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Some evidence suggests that both hypothermia and anesthesia can exert similar effects on metabolism and ventilation. This study examined the synergistic effects of anesthesia and hypothermia on ventilation in spontaneously breathing adult mice under three different conditions, that is, (1) pentobarbital group ( n = 7) in which mice were anesthetized with intraperitoneal pentobarbital of 80 mg/kg, (2) sevoflurane‐continued group ( n = 7) in which mice were anesthetized with 1 MAC sevoflurane, and (3) sevoflurane‐discontinued group ( n = 7) in which sevoflurane was discontinued at a body temperature below 22˚C. We cooled mice in each group until breathing ceased and followed this with artificial rewarming while measuring changes in respiratory variables and heart rate. We found that the body temperature at which respiration arrested is much lower in the sevoflurane‐discontinued group (13.8 ± 2.0˚C) than that in the sevoflurane‐continued group (16.7 ± 1.2˚C) and the pentobarbital group (17.0 ± 1.4˚C). Upon rewarming, all animals in all three groups spontaneously recovered from respiratory arrest. There was a considerable difference in breathing patterns between sevoflurane‐anesthetized mice and pentobarbital‐anesthetized mice during progressive hypothermia in terms of changes in tidal volume and respiratory frequency. The changes in the respiratory pattern during rewarming are nearly mirrored images of the changes observed during cooling in all three groups. These observations indicate that adult mice are capable of autoresuscitation from hypothermic respiratory arrest and that anesthesia and hypothermia exert synergistic effects on the occurrence of respiratory arrest while the type of anesthetic affects the breathing pattern that occurs during progressive hypothermia leading to respiratory arrest.

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“…The suppression effect of anesthetics on the forebrain, including the cortex and the thalamus, is stronger than that on the brainstem [35]. Meanwhile, studies have shown that the preBötzinger complex, the involuntary respiratory control center, is less susceptible to the anesthetics [36,37]. These relations suggest that under deeper level of anesthesia, the non-rhythmic respiratory is more suppressed than the rhythmic respiratory center.…”

Section: Perspective From Physiologymentioning

confidence: 99%

The Modeling and Quantification of Rhythmic to Non-rhythmic Phenomenon in Electrocardiography during Anesthesia

Lin¹

2015

Preprint

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Variations of instantaneous heart rate appears regularly oscillatory in deeper levels of anesthesia and less regular in lighter levels of anesthesia. It is impossible to observe this "rhythmic-to-non-rhythmic" phenomenon from raw electrocardiography waveform in current standard anesthesia monitors. To explore the possible clinical value, I proposed the adaptive harmonic model, which fits the descriptive property in physiology, and provides adequate mathematical conditions for the quantification. Based on the adaptive harmonic model, multitaper Synchrosqueezing transform was used to provide time-varying power spectrum, which facilitates to compute the quantitative index: "Non-rhythmicto-Rhythmic Ratio" index (NRR index). I then used a clinical database to analyze the behavior of NRR index and compare it with other standard indices of anesthetic depth.The positive statistical results suggest that NRR index provides addition clinical information regarding motor reaction, which aligns with current standard tools. Furthermore, the ability to indicates the noxious stimulation is an additional finding. Lastly, I have proposed an real-time interpolation scheme to contribute my study further as a clinical application.

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Effects of sevoflurane on respiratory rhythm oscillators in the medulla oblongata

Cited by 14 publications

References 33 publications

Isolated in vitro brainstem–spinal cord preparations remain important tools in respiratory neurobiology

Isolated in vitro brainstem–spinal cord preparations remain important tools in respiratory neurobiology

Changes in breathing pattern during severe hypothermia and autoresuscitation from hypothermic respiratory arrest in anesthetized mice

The Modeling and Quantification of Rhythmic to Non-rhythmic Phenomenon in Electrocardiography during Anesthesia

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