Effects of sex hormones on genioglossal muscle contractility and SR Ca2+-ATPase activity in aged rat

Liu, Yuehua; Qi, Juan; Hou, Yu-xia; Wang, Fei

doi:10.1016/j.archoralbio.2007.10.009

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…The present study is the first to compare the in vivo effects of the phytoestrogens, genistein and coumestrol, on the contractile properties of genioglossus from ovariectomized rats with CIH. The twitch tension and initial tetanic tension were very similar in the three study groups, which is consistent with the results of our previous studies on the effects of sex hormones on genioglossus contractility (16, 41, 42). Furthermore, we observed that genistein and coumestrol could improve the fatigue resistance of genioglossus in female rats, which was also similar to the effect of estrogen on rat genioglossus (16, 41–43).…”

Section: Discussionsupporting

confidence: 91%

“…The twitch tension and initial tetanic tension were very similar in the three study groups, which is consistent with the results of our previous studies on the effects of sex hormones on genioglossus contractility (16, 41, 42). Furthermore, we observed that genistein and coumestrol could improve the fatigue resistance of genioglossus in female rats, which was also similar to the effect of estrogen on rat genioglossus (16, 41–43). We previously investigated the effects of estrogen on the contractile properties of the genioglossus in male rats (41, 42) and in ovariectomized female rats (16, 43), with or without CIH.…”

Section: Discussionsupporting

confidence: 91%

“…Furthermore, we observed that genistein and coumestrol could improve the fatigue resistance of genioglossus in female rats, which was also similar to the effect of estrogen on rat genioglossus (16,(41)(42)(43). We previously investigated the effects of estrogen on the contractile properties of the genioglossus in male rats (41,42) and in ovariectomized female rats (16,43), with or without CIH. On the whole, estrogen could improve the genioglossus contractile properties, especially the fatigue resistance, in both male and female rats.…”

Section: Discussionmentioning

confidence: 68%

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Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Huang

Liu

2011

European Journal of Oral Sciences

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Chronic intermittent hypoxia (CIH) is a frequent feature of obstructive sleep apnea/hypopnea syndrome (OSAHS), and it may alter upper airway muscle endurance. We have previously reported the positive effects of estrogen on genioglossus fatigue resistance in rats. Our present study was designed to evaluate the effects of two phytoestrogens - genistein and coumestrol - on genioglossus contractile function and estrogen receptor (ER) expression in female rats exposed to CIH. Eight-wk-old female rats were ovariectomized and exposed to CIH for 5 wk. Genistein and coumestrol, respectively, were administered by intraperitoneal injection, at a dose of 2.5 mg kg(-1) d(-1), during the last 4 d of exposure to CIH. The contractile properties of the genioglossus were measured. Real-time RT-PCR and western blotting were performed to determine the expression of ERs in the genioglossus. Phytoestrogens were found to significantly increase genioglossus fatigue resistance, the effect of genistein being more powerful than that of coumestrol. However, higher levels of ER mRNA and protein were detected in the coumestrol group than in the genistein group. We conclude that phytoestrogens, especially genistein, could improve the endurance of the genioglossus muscle in ovariectomized rats exposed to CIH, and this effect is, in part, not related to its estrogenic action.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 68%

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Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Huang

Liu

2011

European Journal of Oral Sciences

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“…To our knowledge, only one study (Liu et al . ) has examined the effects of sex hormones on skeletal muscle Ca 2+ handling. In aged male rats, oestrogen injections had little effect on genioglossal muscle SR Ca 2+ ‐ATPase activity (Liu et al .…”

Section: Discussionmentioning

confidence: 99%

Effects of type 1 diabetes, sprint training and sex on skeletal muscle sarcoplasmic reticulum Ca²⁺ uptake and Ca²⁺‐ATPase activity

Harmer

Ruell

Hunter

et al. 2014

The Journal of Physiology

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Key pointsr Skeletal muscle calcium resequestration and performance is increased in male rats with induced diabetes; and whilst muscle calcium resequestration is important during exercise, it has not been investigated in human diabetes or compared between sexes.r We show that Ca 2+ -ATPase activity and Ca 2+ uptake are higher among people with type 1 diabetes (T1D) compared with matched non-diabetic controls (CON), but that performance during intense exercise was similar; Ca 2+ -ATPase activity and Ca 2+ uptake are also higher among men than women.r We show that Ca 2+ -ATPase activity is reduced during intense exercise in men but not women, and is reduced by high-intensity exercise training (HIET) in T1D and CON.r Fatigue is commonly reported by people with diabetes, but our data show that muscle calcium resequestration and performance during intense exercise and after HIET is not impaired in T1D, and hence other physiological or psychological mechanisms for fatigue in diabetes must be sought.r Sex influences muscle calcium regulation.Abstract Calcium cycling is integral to muscle performance during the rapid muscle contraction and relaxation of high-intensity exercise. Ca 2+ handling is altered by diabetes mellitus, but has not previously been investigated in human skeletal muscle. We investigated effects of high-intensity exercise and sprint training on skeletal muscle Ca 2+ regulation among men and women with type 1 diabetes (T1D, n = 8, 3F, 5M) and matched non-diabetic controls (CON, n = 8, 3F, 5M). Secondarily, we examined sex differences in Ca 2+ regulation. Subjects undertook 7 weeks of three times-weekly cycle sprint training. Before and after training, performance was measured, and blood and muscle were sampled at rest and after high-intensity exercise. In T1D, higher Ca 2+ -ATPase activity (+28%) and Ca 2+ uptake (+21%) than in CON were evident across both times and days (P < 0.05), but performance was similar. In T1D, resting Ca 2+ -ATPase activity correlated with work performed until exhaustion (r = 0.7, P < 0.01). Ca 2+ -ATPase activity, but not Ca 2+ uptake, was lower (−24%, P < 0.05) among the women across both times and days. Intense exercise did not alter Ca 2+ -ATPase activity in T1D or CON. However, sex differences were evident: Ca 2+ -ATPase was reduced with exercise among men but increased among women across both days (time × sex interaction, P < 0.05). Sprint training reduced Ca 2+ -ATPase (−8%, P < 0.05), but not Ca 2+ uptake, in T1D and CON. In summary, skeletal muscle Ca 2+ resequestration capacity was increased in T1D, but performance was not greater than CON. Sprint training reduced

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“…Testosterone has been shown to affect SERCA (sarco-endoplasmic reticulum calcium ATPase) activity in vivo . Liu et al found that T inhibits SR Ca 2+ -ATPase pumping activity in a fast twitch muscle in mice (Liu et al, 2008). In this way a higher concentration of Ca 2+ binds troponin C and slows muscle relaxation overall.…”

Section: Discussionmentioning

confidence: 99%

Effects of testosterone on contractile properties of sexually dimorphic forelimb muscles in male bullfrogs (Rana catesbeiana, Shaw 1802)

Kampe

Peters

2013

Biology Open

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SummaryThis study examined the effects of testosterone (T) on the contractile properties of two sexually dimorphic forelimb muscles and one non-dimorphic muscle in male bullfrogs (Rana catesbeiana, Shaw 1802). The dimorphic muscles in castrated males with testosterone replacement (T+) achieved higher forces and lower fatigability than did castrated males without replaced testosterone (T0 males), but the magnitude of the differences was low and many of the pair-wise comparisons of each muscle property were not statistically significant. However, when taken as a whole, the means of seven contractile properties varied in the directions expected of masculine values in T+ animals in the sexually dimorphic muscles. Moreover, these data, compared with previous data on male and female bullfrogs, show that values for T+ males are similar to normal males and are significantly different from females. The T0 males tended to be intermediate in character between T+ males and females, generally retaining masculine values. This suggests that the exposure of young males to T in their first breeding season produces a masculinizing effect on the sexually dimorphic muscles that is not reversed between breeding seasons when T levels are low. The relatively minor differences in contractile properties between T+ and T0 males may indicate that as circulating T levels rise during breeding season in normal males, contractile properties can be enhanced rapidly to maximal functional levels for breeding success.

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Effects of sex hormones on genioglossal muscle contractility and SR Ca2+-ATPase activity in aged rat

Cited by 11 publications

References 34 publications

Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Effects of type 1 diabetes, sprint training and sex on skeletal muscle sarcoplasmic reticulum Ca²⁺ uptake and Ca²⁺‐ATPase activity

Effects of testosterone on contractile properties of sexually dimorphic forelimb muscles in male bullfrogs (Rana catesbeiana, Shaw 1802)

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Effects of sex hormones on genioglossal muscle contractility and SR Ca2+-ATPase activity in aged rat

Cited by 11 publications

References 34 publications

Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity

Effects of type 1 diabetes, sprint training and sex on skeletal muscle sarcoplasmic reticulum Ca2+ uptake and Ca2+‐ATPase activity

Effects of testosterone on contractile properties of sexually dimorphic forelimb muscles in male bullfrogs (Rana catesbeiana, Shaw 1802)

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Effects of type 1 diabetes, sprint training and sex on skeletal muscle sarcoplasmic reticulum Ca²⁺ uptake and Ca²⁺‐ATPase activity