2023
DOI: 10.1101/2023.07.05.547871
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Effects of sexual dimorphism and estrous cycle onC. difficileinfections in rodent models

Jacqueline R. Phan,
McKenzie Washington,
Dung M. Do
et al.

Abstract: Clostridioides difficile infection (CDI) is responsible for the majority of identifiable hospital-related antibiotic-associated diarrhea. Susceptibility to CDI and severity of disease varies depending on a variety of factors such as aggressive use of broad-spectrum antibiotics, age, and immune status. Epidemiological studies have consistently shown that female patients are more at risk for CDI than their male counterparts. In this study, we show that female mice developed more severe CDI than their male counte… Show more

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