Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats

Chiang, Tzu-Yi; Wang, Hong-Jaan; Wang, Yen-Cih; Tan, Elise Chia‐Hui; Lee, I-Jung; Yun, Chul‐Ho; Ueng, Yune-Fang

doi:10.1016/j.jep.2021.113914

Cited by 10 publications

(21 citation statements)

References 41 publications

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“…SMS selectively suppressed intestinal, but not hepatic, nifedipine oxidation (a CYP3A marker reaction) activity in a dose-and time-dependent manner. Three-week SMS treatment decreased the maximal velocity of intestinal nifedipine oxidation by 50%, while the CYP3A protein level remained unchanged; among the SMS component herbs, the decoction of Ophiopogonis Radix decreased the intestinal nifedipine oxidation activity [195]. Based on an inhibition kinetic investigation of various UGT isoforms, ophiopogonin D was found to noncompetitively inhibit UGT1A6 (K i , 20.6 µmol/L) and competitively inhibit UGT1A8 (40.1 µmol/L); ophiopogonin D' noncompetitively inhibited UGT1A6 (5.3 µmol/L) and UGT1A10 (9.0 µmol/L); and ruscorectal competitively inhibited UGT1A4 (0.02 µmol/L) [106].…”

Section: Shengmai Formulamentioning

confidence: 92%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines.

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Section: Shengmai Formulamentioning

confidence: 92%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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“…A 1-h pretreatment of rats with SMS decreased nifedipine clearance, accompanied by decreased hepatic oxidation activity, which was primarily catalyzed by CYP3A [ 133 ]. However, 3-week repeated oral treatments with SMS suppressed rat intestinal, but not hepatic, nifedipine oxidation activity [ 134 ]. Accordingly, nifedipine clearance decreased and AUC t increased.…”

Section: Potential Hdis Between Tcm Formulas and Prescribed Cvd Drugsmentioning

confidence: 99%

Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases

Liang¹,

Hsu²,

Chang³

et al. 2022

Journal of Food and Drug Analysis

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Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb–drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of cardiovascular disease (CVD), which is currently the leading cause of disease-related mortality worldwide. A total of 55 HDIs are summarized, and their potential underlying mechanisms are examined. The pharmacokinetic (PK) and pharmacodynamic (PD) effects of three single herbs (Danshen, Ginseng, and Ginkgo) and four compound prescriptions (Shenmai injection, Shengmai-San, Shu-Jing-Hwo-Shiee-Tang, and Wu-Chu-Yu-Tang) are discussed. Due to the complex compositions and PK/PD profiles of TCMs, the determinants of significant HDIs have been listed to further define the pros and cons of HDIs in medical care.

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“…of S. chinensis extract (equivalent to 15 mg/kg schisandrol B), the oral absolute bioavailability of schisandrol B was approximately 18.73% and 68.12%, respectively [16]. Schisandrin B could modulate cytochrome P450 3A activity (CYP3A) in vivo in rats and also altered the pharmacokinetic profiles of other CYP3A substrates [17]. The tissue distribution studies showed that schisandrin B [18] and schisandrol B were distributed throughout several tested tissues and accumulated mainly in in the liver and kidneys [16,18].…”

Section: Bioavailability Of Schisandra Chinensis Fruit Extract and Its Constituentsmentioning

confidence: 99%

“…Antioxidants 2021, 10, x FOR PEER REVIEW 3 of 11 other CYP3A substrates [17]. The tissue distribution studies showed that schisandrin B [18] and schisandrol B were distributed throughout several tested tissues and accumulated mainly in in the liver and kidneys [16,18].…”

Section: Biological Activity Of Schisandra Chinensis Fruit Extract and Its Constituents: Main Mechanisms Of Actionmentioning

confidence: 99%

Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents

Kopustinskienė

Bernatonienė

2021

Antioxidants

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Schisandra chinensis Turcz. (Baill.) fruits, their extracts, and bioactive compounds are used in alternative medicine as adaptogens and ergogens protecting against numerous neurological, cardiovascular, gastrointestinal, liver, and skin disorders. S. chinensis fruit extracts and their active compounds are potent antioxidants and mitoprotectors exerting anti-inflammatory, antiviral, anticancer, and anti-aging effects. S. chinensis polyphenolic compounds—flavonoids, phenolic acids and the major constituents dibenzocyclooctadiene lignans are responsible for the S. chinensis antioxidant activities. This review will focus on the direct and indirect antioxidant effects of S. chinensis fruit extract and its bioactive compounds in the cells during normal and pathological conditions.

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Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats

Cited by 10 publications

References 41 publications

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases

Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents

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