Effects of Shiftwork on Sleep Patterns of Nurses

Ss, Hwang; Sb, Hong; Yw, Hwang; Hwang, Eun Jung; Ju, Hwang; Rg, Hwang; Hy, Hwang; Park, Jin Gyu; Ju, Young Seok; Sj, Lee; Sung, Jae Hoon; Kang, Daehee; Cho, Seung-Hun; Dr, Yun

doi:10.35371/kjoem.1998.10.1.1

Cited by 12 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This process targets them for degradation by cytosolic proteasomes. ERAD has multiple components such as HRD1, EDEM, SEL1, and OS-9 [137]. Each of them has a different function in ERAD.…”

Section: Erad In Cardiovascular Diseasementioning

confidence: 99%

Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

Zhang

Wang

Gillette

et al. 2019

CTMC

View full text Add to dashboard Cite

Cardiovascular disease is the leading cause of death worldwide. Despite overwhelming socioeconomic impact and mounting clinical needs, our understanding of the underlying pathophysiology remains incomplete. Multiple forms of cardiovascular disease involve an acute or chronic disturbance in cardiac myocytes, which may lead to potent activation of the Unfolded Protein Response (UPR), a cellular adaptive reaction to accommodate protein-folding stress. Accumulation of unfolded or misfolded proteins in the Endoplasmic Reticulum (ER) elicits three signaling branches of the UPR, which otherwise remain quiescent. This ER stress response then transiently suppresses global protein translation, augments production of protein-folding chaperones, and enhances ER-associated protein degradation, with an aim to restore cellular homeostasis. Ample evidence has established that the UPR is strongly induced in heart disease. Recently, the mechanisms of action and multiple pharmacological means to favorably modulate the UPR are emerging to curb the initiation and progression of cardiovascular disease. Here, we review the current understanding of the UPR in cardiovascular disease and discuss existing therapeutic explorations and future directions.

show abstract

“…This process targets them for degradation by cytosolic proteasomes. ERAD has multiple components such as HRD1, EDEM, SEL1, and OS-9 [137]. Each of them has a different function in ERAD.…”

Section: Erad In Cardiovascular Diseasementioning

confidence: 99%

Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

Zhang

Wang

Gillette

et al. 2019

CTMC

View full text Add to dashboard Cite

show abstract

“…Despite the location and subtype, collagens share a triple-helical supersecondary structure with three polypeptide chains that unfold at body temperature following initial protease cleavage. [13][14][15] Conventional methods to detect collagen include histological staining and immunohistochemistry (IHC). Specifically, histological staining of collagen relies on strong binding between ionic dyes with collagen proteins, such as Picrosirius red, which stains all collagens irrespective of sub-type or structural integrity.…”

Section: Introductionmentioning

confidence: 99%

“…They have been shown to specifically bind to collagens degraded or destroyed by a variety of factors including enzymatic digestion, heat denaturing, and mechanical injury via triple helix hybridization. [13][14][15]24,25 The CHP method, outlined in Figure 1b, provides a number of advantages over common histological methods, such as operational simplicity and protocol efficiency ( Figure 1c).…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection and Assessment of Intervertebral Disc Degeneration via a Collagen Hybridizing Peptide

Xiao

Majumdar

Dai

et al. 2019

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

During aging, wear, and tear of intervertebral discs, human discs undergo a series of morphological and biochemical changes. Degradation of extracellular matrix proteins, e.g., collagen, arises as an important contributor and accelerator in this process. Existing methods to detect collagen degradation at the tissue level include histology and immunohistochemistry. Unfortunately, most of these methods only depict overall collagen content without the ability to specifically discern degraded collagen and to assess the severity of degeneration. To fill this technological gap, we developed a robust and simple approach to detect and assess early disc degeneration with a collagen hybridizing peptide (CHP) that hybridizes with the flawed triple

show abstract

“…1 Since then, over thirty rocaglate natural products have been identified with unique structures and intriguing biological activities. 2,3,4 For instance, silvestrol (1, Figure 1) 5 was identified as an excellent translation inhibitor for cancer chemotherapy, 6 whereas other related natural products and analogues (2)(3)(4) displayed similar activities. 7 In our previous studies, translation inhibition was found to be associated with inhibition of the DEAD box RNA helicase eIF4A.…”

Section: Introductionmentioning

confidence: 99%

Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection

Zhang

Maïga³

et al. 2018

J. Am. Chem. Soc.

View full text Add to dashboard Cite

As a unique rocaglate (flavagline) natural product, aglaroxin C displays intriguing biological activity by inhibiting HCV viral entry. To further elucidate structure-activity relationships and diversify the pyrimidinone scaffold, we report a concise synthesis of aglaroxin C utilizing a highly regioselective pyrimidinone condensation. We have prepared more than forty aglaroxin C analogues utilizing various amidine condensation partners. Through biological evaluation of analogues, we have discovered two lead compounds, CMLD012043 and CMLD012044, which show preferential bias for the inhibition of HCV viral entry vs. translation inhibition. Overall, the study demonstrates the power of chemical synthesis to produce natural product variants with both target inhibition bias and improved therapeutic indexes.

show abstract

Effects of Shiftwork on Sleep Patterns of Nurses

Cited by 12 publications

References 0 publications

Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

Molecular Detection and Assessment of Intervertebral Disc Degeneration via a Collagen Hybridizing Peptide

Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection

Contact Info

Product

Resources

About