Effects of short- and long-term exposure to air pollution and meteorological factors on Meniere’s disease

Abstract

The association between air pollutants and Meniere’s disease has not been explored. The present study investigated the relationship between meteorological factors and air pollutants on Meniere’s disease. Participants, aged ≥ 40 years, of the Korean National Health Insurance Service-Health Screening Cohort were included in this study. The 7725 patients with Meniere’s disease were matched with 30,900 control participants. The moving average meteorological and air pollution data of the previous 7 days, 1 month, 3 months, and 6 months before the onset of Meniere’s disease were compared between the Meniere’s disease and control groups using conditional logistic regression analyses. Additional analyses were conducted according to age, sex, income, and residential area. Temperature range; ambient atmospheric pressure; sunshine duration; and levels of SO2, NO2, O3, CO, and PM10 for 1 month and 6 months were associated with Meniere’s disease. Adjusted ORs (odds ratios with 95% confidence interval [CI]) for 1 and 6 months of O3 concentration were 1.29 (95% CI 1.23–1.35) and 1.31 (95% CI 1.22–1.42), respectively; that for the 1 and 6 months of CO concentration were 3.34 (95% CI 2.39–4.68) and 4.19 (95% CI 2.79–6.30), respectively. Subgroup analyses indicated a steady relationship of O3 and CO concentrations with Meniere’s disease. Meteorological factors and air pollutants were associated with the rate of Meniere’s disease. In particular, CO and O3 concentrations were positively related to the occurrence of Meniere’s disease.

Meteorological extremes and their impact on tinnitus-related emergency room visits: a time-series analysis

“…Atmospheric pressure has been the best-described meteorological factor influencing MD attacks and tinnitus severity. Higher atmospheric pressure was positively correlated with the diagnosis of MD in a large-scale study analyzing over 7000 cases in South Korea [ 30 ]. Another prospective study identified increases in atmospheric pressure as risk factors for an MD episode on the following day [ 29 ].…”

“…Another link has been drawn between high relative humidity and increased frequency of Ménière’s attacks and tinnitus [ 21 , 30 ]. Our study found comparable results for tinnitus-related EVs independent of MD with extremely low relative humidity reducing EV risk within one day and a same-day increase in risk under extremely humid conditions.…”

Acute effects of ambient air pollution on daily neurology clinic visits for vertigo: a time-series study in Wuhan, China

“…One study conducted in Korea revealed that O 3 exposure was associated with high incidence of Ménière's disease. Groundlevel O 3 in Wuhan is mainly produced by photochemical reactions of nitrogen oxides and volatile organic compounds (Choi et al, 2021). As the powerful inhaled oxidizing agent, studies showed that oxidative stress induced by O 3 exposure intimately linked with brain lipid peroxidation, neuroin ammation and subsequent neuron damage and impaired cerebral vascular endothelial injury (Cai et al, 2016;Yang et al, 2019).…”

Acute effects of ambient air pollution on daily neurology clinic visits for vertigo: a time-series study in Wuhan, China

“…One study conducted in Korea revealed that O 3 exposure was associated with high incidence of Ménière's disease. Groundlevel O 3 in Wuhan is mainly produced by photochemical reactions of nitrogen oxides and volatile organic compounds (Choi et al, 2021). As the powerful inhaled oxidizing agent, studies showed that oxidative stress induced by O 3 exposure intimately linked with brain lipid peroxidation, neuroin ammation and subsequent neuron damage and impaired cerebral vascular endothelial injury (Cai et al, 2016;Yang et al, 2019).…”