Effects of short <scp>RNA</scp> structural analogues against hepatitis <scp>C</scp> virus genotypes 2, 3 and 4 in replicon cells

Elshaffei, Ismail Mohamed; Gupta, Nidhi; Wu, Catherine H.; Wu, David C; Hammad, Lamiaa N.; Abo-Elmatty, Dina M.; Mesbah, Noha M.; Wu, George Y.

doi:10.1111/1751-2980.12250

J of Digest Diseases

2015

DOI: 10.1111/1751-2980.12250

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Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells

Ismail Mohamed Elshaffei

Nidhi Gupta²,

Catherine H. Wu³

et al.

Abstract: Despite substantial sequence dissimilarity, HCV RNA genotype 1b X region analogues cross-inhibited the replication of HCV genotypes 2a, 3a and 4a. Particular conformations and not the sequence of the stem-loops of the X region are involved in HCV replication.

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Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells

Abstract: Despite substantial sequence dissimilarity, HCV RNA genotype 1b X region analogues cross-inhibited the replication of HCV genotypes 2a, 3a and 4a. Particular conformations and not the sequence of the stem-loops of the X region are involved in HCV replication.

Cited by 0 publications

References 21 publications

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