Effects of short-term exposures to ultrafine particles near an airport in healthy subjects

Lammers, Ariana; Janssen, Nicole; Boere, A. John F.; Berger, M.; Longo, Cristina; Vijverberg, Susanne; Neerincx, Anne H.; Zee, Anke‐Hilse Maitland‐van der; Cassee, Flemming R.

doi:10.1016/j.envint.2020.105779

Cited by 46 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Pirhadi et al. , 5 h averages of total PNC ranged between 10,500 and 173,200/cm 3 at the exposure site ( Lammers et al., 2020 ), with aviation activity contributing most to PNC exposure for the majority of the study period and individuals ( Fig. 2 A–B) ( Pirhadi et al., 2020 ).…”

Section: Resultsmentioning

confidence: 62%

“…Participants were aged between 20 and 23 years, were predominantly female (81%) and had BMIs within healthy range (22.6 kg/m 2 ± 2.4). All participants had normal cardiopulmonary function as determined by measurements of forced expiratory volume (FEV 1 ), forced vital capacity (FVC), peak expiratory flow (PEF), fractional exhaled nitric oxide (FeNO), blood pressure, heart rate and oxygen saturation (presented previously in Table 2 of Lammers et al. 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…Details of the model and instruments used to collect the input data are provided by Pirhadi et al. (2020) ( Pirhadi et al., 2020 ) and Lammers et al. (2020) ( Lammers et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…(2020) ( Pirhadi et al., 2020 ) and Lammers et al. (2020) ( Lammers et al., 2020 ). To summarise the sources of the UFP, air within the exposure chamber was sampled continuously and subjected to measurement for particle number concentrations (PNCs) and PM mass (gravimetrically), carbon monoxide (CO), black carbon (BC) and nitrogen oxides (NO x ).…”

Section: Methodsmentioning

confidence: 99%

“…Heightened concentrations of pro-inflammatory mediator IL-6 were also observed in the blood of asthmatic adults following a 2-h walk in the high UFP-zone surrounding Los Angeles International Airport (LAX) ( Habre et al., 2018 ). Supported by evidence that exposure to UFP from Amsterdam Airport Schiphol associates with mild reductions in lung and cardiac function (decreased forced vital capacity and prolonged QTc intervals) in healthy young individuals ( Lammers et al., 2020 ). While studies of adverse health effects and UFP exposure in airport workers remain scarce and inconclusive ( Merzenich et al., 2021 ), the adverse effects that we see in these interventional and in vitro studies are consistent with those induced by diesel exhaust particles (DEP) ( Bendtsen et al., 2021 ).Together with evidence that ultrafine DEP and aviation UFP have similar physicochemical properties ( Bendtsen et al., 2021 ), these findings confirm the credibility of concern regarding aviation-related UFP exposure and health.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport

Selley

Lammers

Guennec

et al. 2021

International Journal of Hygiene and Environmental Health

View full text Add to dashboard Cite

Background Inflammation, oxidative stress and reduced cardiopulmonary function following exposure to ultrafine particles (UFP) from airports has been reported but the biological pathways underlying these toxicological endpoints remain to be explored. Urinary metabolomics offers a robust method by which changes in cellular pathway activity can be characterised following environmental exposures. Objective We assessed the impact of short-term exposures to UFP from different sources at a major airport on the human urinary metabolome. Methods 21 healthy, non-smoking volunteers (aged 19–27 years) were repeatedly (2–5 visits) exposed for 5h to ambient air at Amsterdam Airport Schiphol, while performing intermittent, moderate exercise. Pre- to-post exposure changes in urinary metabolite concentrations were assessed via 1 H NMR spectroscopy and related to total and source-specific particle number concentrations (PNC) using linear mixed effects models. Results Total PNC at the exposure site was on average, 53,500 particles/cm 3 (range 10,500–173,200) and associated with significant reductions in urinary taurine (−0.262 AU, 95% CI: −0.507 to −0.020) and dimethylamine concentrations (−0.021 AU, 95% CI: −0.040 to −0.067). Aviation UFP exposure accounted for these changes, with the reductions in taurine and dimethylamine associating with UFP produced during both aircraft landing and take-off. Significant reductions in pyroglutamate concentration were also associated with aviation UFP specifically, (−0.005 AU, 95% CI: −0.010 – <0.000) again, with contributions from both landing and take-off UFP exposure. While non-aviation UFPs induced small changes to the urinary metabolome, their effects did not significantly impact the overall response to airport UFP exposure. Discussion Following short-term exposures at a major airport, aviation-related UFP caused the greatest changes to the urinary metabolome. These were consistent with a heightened antioxidant response and altered nitric oxide synthesis. Although some of these responses could be adaptive, they appeared after short-term exposures in healthy adults. Further study is required to determine whether long-term exposures induce injurious effects.

show abstract

Section: Resultsmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

“…Details of the model and instruments used to collect the input data are provided by Pirhadi et al. (2020) ( Pirhadi et al., 2020 ) and Lammers et al. (2020) ( Lammers et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport

Selley

Lammers

Guennec

et al. 2021

International Journal of Hygiene and Environmental Health

View full text Add to dashboard Cite

show abstract

PM2.5 decadal data in cold vs. mild climate airports: COVID-19 era and a call for sustainable air quality policy

Rangel-Alvarado

Pal

Ariya

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Airports are identified hotspots for air pollution, notably for fine particles (PM 2.5 ) that are pivotal in aerosol-cloud interaction processes of climate change and human health. We herein studied the field observation and statistical analysis of 10-year data of PM 2.5 and selected emitted co-pollutants (CO, NO x , and O 3 ), in the vicinity of three major Canadian airports, with moderate to cold climates. The decadal data analysis indicated that in colder climate airports, pollutants like PM 2.5 and CO accumulate disproportionally to their emissions in fall and winter, in comparison to airports in milder climates. Decadal daily averages and standard errors of PM 2.5 concentrations were as follows: Vancouver, 5.31 ± 0.017; Toronto, 6.71 ± 0.199; and Montreal, 7.52 ± 0.023 μg/m 3 . The smallest and the coldest airport with the least flights/passengers had the highest PM 2.5 concentration. QQQ-ICP-MS/MS and HR-S/TEM analysis of aerosols near Montreal Airport indicated a wide range of emerging contaminants (Cd, Mo, Co, As, Ni, Cr, and Pb) ranging from 0.90 to 622 μg/L, which were also observed in the atmosphere. During the lockdown, a pronounced decrease in the concentrations of PM 2.5 and submicron particles, including nanoparticles , in residential areas close to airports was observed, conforming with the recommended workplace health thresholds (~ 2 × 10 4 cm −3 ), while before the lockdown, condensable particles were up to ~ 1 × 10 5 cm −3 . Targeted reduction of PM 2.5 emission is recommended for cold climate regions. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11356-022-19708-8.

show abstract

Estimating the economic value of ultrafine particle information: a contingent valuation method

Cho

2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Effects of short-term exposures to ultrafine particles near an airport in healthy subjects

Cited by 46 publications

References 43 publications

Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport

Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport

PM2.5 decadal data in cold vs. mild climate airports: COVID-19 era and a call for sustainable air quality policy

Estimating the economic value of ultrafine particle information: a contingent valuation method

Contact Info

Product

Resources

About