Effects of Short-Term Inhaled Nitric Oxide on Interleukin-8 Release After Single-Lung Transplantation in Pigs

Inhaled Nitric Oxide for Modulation of Ischemia–Reperfusion Injury in Lung Transplantation

“…35 In keeping with our previous findings, BAL IL-8 levels correlated significantly with the development of PGD. 36 However, we could not demonstrate any significant impact of the prophylactic administration of NO on IL-8 expression/up-regulation during reperfusion.…”

Technical Pearls for Swine Lung Transplantation

“…Swine is the most commonly used large animal model of lung transplantation; often in studies of drug effects on ischemia/reperfusion injury [3,[7][8][9][10], EVLP [1,3] and in xenotransplantation [11,12]. An adequate understanding of pig lung anatomy is important for those beginning experimental protocols.…”

“…An adequate understanding of pig lung anatomy is important for those beginning experimental protocols. In our review of the literature, we could not find an article dedicated to the technique of swine lung transplantation; nevertheless, several articles briefly describe their donor and recipient preparation [1,[7][8][9][10]12]. In our described model, a single stage cross-clamp is applied to the left pulmonary hilum and obviates the need for sequential clamping.…”

Cell-Cell Junctions and Vascular Endothelial Growth Factor in Rat Lung as Affected by Ischemia/Reperfusion and Preconditioning With Inhaled Nitric Oxide

“…The release of NO is one of the essential steps in the trigger mechanism of preconditioning [9,10] and, consequently, the shortterm inhalation of NO before the onset of ischemia has been demonstrated to protect the lung against I/R injury [11][12][13][14][15][16], which includes protection against impairment of the permeability barrier [11][12][13].…”