Effects of Short-Term Propylthiouracil Treatment on P Wave Duration and P Wave Dispersion in Patients with Overt Hypertyroidism

Katırcıbaşı, Mahmut Tuna; Denız, Ferhat; Pamukçu, Burak; Binici, Süleyman; Atar, İnci Aslı

doi:10.1055/s-2007-971066

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…1). 3 , 7–85 Fourteen of these articles utilized only a computer‐assisted technique for P‐wave evaluation.…”

Section: Resultsmentioning

confidence: 99%

Meta‐Analysis of P‐Wave Dispersion Values in Healthy Individuals: The Influence of Clinical Characteristics

Nussinovitch¹

2012

Noninvasive Electrocardiol

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Pd, Pmax, and Pmin span a wide range of values in healthy individuals. Seemingly, abnormal values were often reported in healthy adults. The high variability of P-wave parameters in healthy individuals, and overlapping of the results with those reported for patients with increased risk for atrial fibrillation, might suggest that this technique has limited sensitivity and specificity. The variability between studies may stem from methodological issues and, therefore, there is a definite need for methodological standardization of Pd measurements.

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“…1). 3 , 7–85 Fourteen of these articles utilized only a computer‐assisted technique for P‐wave evaluation.…”

Section: Resultsmentioning

confidence: 99%

Meta‐Analysis of P‐Wave Dispersion Values in Healthy Individuals: The Influence of Clinical Characteristics

Nussinovitch¹

2012

Noninvasive Electrocardiol

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“…Moreover, Guntekin et al 29 and Katircibasi et al 30 found that maximum P-wave duration and P-wave dispertion were increased in hyperthyroidism and treatment with PTU resulted in improvement in P-wave variables. A study by Aras and colleagues 6 reported that simply measuring P maximum and Pwave dispertion values could identify the patients with high risk for the development of atrial fibrillation.…”

Section: Discussionmentioning

confidence: 98%

“…A study by Aras and colleagues 6 reported that simply measuring P maximum and Pwave dispertion values could identify the patients with high risk for the development of atrial fibrillation. Moreover, Guntekin et al 29 and Katircibasi et al 30 found that maximum P-wave duration and P-wave dispertion were increased in hyperthyroidism and treatment with PTU resulted in improvement in P-wave variables. To the best of our knowledge, the effects of antithyroid therapy on atrial electromechanical coupling assessed by TDI was not studied before.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Antithyroid Treatment on Atrial Conduction Times in Patients with Subclinical Hyperthyroidism

Nacar

Acar²,

Yorgun

et al. 2012

Echocardiography

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“…The major portion of the PR interval includes the P wave duration, and there have been many studies regarding the P wave duration or dispersion related to aging, 18 uncontrolled hypertension, 1 diabetes, 2 or obesity. 19 Furthermore, a prolonged P wave duration and dispersion have been known to be associated with aortic stenosis, 20 mitral stenosis, 21 and coronary artery disease, 3 as well as hyperthyroidism, 22 obstructive sleep apnea, 23 or a higher incidence of AF. 24 In the current study, we found a close association between the PR interval and P wave duration, and a prolonged PR interval predicted the clinical recurrence of AF after catheter ablation.…”

Section: Pr Interval As Prognostic Parameter For Cardiac Disease and Afmentioning

confidence: 99%

Prolonged PR Interval Predicts Clinical Recurrence of Atrial Fibrillation After Catheter Ablation

Park

Kim

Lee

et al. 2014

JAHA

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BackgroundA prolonged PR interval is known to be a poor prognostic factor in cardiovascular disease. The aim of this study was to investigate the association between PR interval and clinical outcome in patients undergoing radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF).Methods and ResultsWe prospectively included 576 patients with AF (75.5% male, 57.8±11.6 years old, 68.8% paroxysmal AF) who underwent RFCA. We analyzed preprocedural sinus rhythm ECGs obtained in the absence of antiarrhythmic drug, and all enrolled patients were categorized into 4 groups based on the quartile values of the PR interval (166, 182, and 202 ms), and were analyzed according to the left atrium (LA) volume (CT; Computed tomography), LA voltage (NavX), and clinical outcome of AF ablation. Based on quartile value of PR interval, the highest quartile of PR interval (Q4; PR ≥202 ms) was oldest (P<0.001), and most likely to have persistent AF (P<0.001) and hypertension (P=0.013) compared with the other groups. However, there was no significant difference in LA conduction velocity and atrial effective refractory period. Q4 had the greatest LA dimension (P<0.001) and volume index (P<0.001), and lowest LA appendage‐emptying velocity (P<0.032) and LA voltage (P<0.001) compared with the others. For 13.1±7.5 months, the classification based on the PR interval was a significant predictor of AF recurrence after RFCA of AF (HR=1.969, 95% CI 1.343 to 2.886, P=0.001).ConclusionsThe PR interval was closely associated with advanced LA remodeling due to AF, and had a noninvasive significant predictive value of clinical recurrence of AF after RFCA.

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Effects of Short-Term Propylthiouracil Treatment on P Wave Duration and P Wave Dispersion in Patients with Overt Hypertyroidism

Abstract: P wave duration and PWD are found prolonged in hyperthyroid patients and propylthiouracil treatment decreased them effectively. This mechanism may establish how the anti-thyroid treatment may prevent the development of atrial fibrillation in hyperthyroid patients.

Cited by 9 publications

References 9 publications

Meta‐Analysis of P‐Wave Dispersion Values in Healthy Individuals: The Influence of Clinical Characteristics

Meta‐Analysis of P‐Wave Dispersion Values in Healthy Individuals: The Influence of Clinical Characteristics

The Effect of Antithyroid Treatment on Atrial Conduction Times in Patients with Subclinical Hyperthyroidism

Prolonged PR Interval Predicts Clinical Recurrence of Atrial Fibrillation After Catheter Ablation

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