Effects of sialic acid derivative on long circulation time and tumor concentration of liposomes

Yamauchi, Hitoshi; Yano, Toshiro; Kato, Takashi; Tanaka, Isao; Nakabayashi, Satoru; Higashi, Kunio; Miyoshi, Shiro; Yamada, Hirotoshi

doi:10.1016/0378-5173(94)00188-b

Cited by 41 publications

(19 citation statements)

References 16 publications

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“…33 Although the mechanism of liposomal surface protection by grafted synthetic polymers, like POZs, must be different from that of GM1, it was important to confirm that polyoxazoline-grafted liposomes exhibited plasma longevity and low hepatosplenic uptake in more than one species. From the experimental observations reported here and in our earlier communication, 15 it appears that POZs convey long circulation properties to liposomes in both rats and mice, similar to PEG.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§

Zalipsky¹,

Hansen

Oaks³

et al. 1996

Journal of Pharmaceutical Sciences

273

165

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Two amphipatic polymers of the poly(2-oxazoline) family, poly(2-methyl-2-oxazoline) (PMOZ) and poly(2-ethyl-2-oxazoline) (PEOZ), were synthesized with the carboxylic group positioned at either the initiation or termination ends of the polymer chains. Distearoylphosphatidylethanolamine was covalently linked to the carboxyl groups of the polymers, resulting in conjugates which incorporate readily into liposomes. Systematic evaluation of plasma clearance kinetics and biodistribution of liposomes containing hydrogenated soy phosphatidylcholine, cholesterol, and 5 mol % the polymer-lipid conjugates in mice revealed the following. Both polymers, PMOZ and PEOZ, exhibited long plasma lifetimes and low hepatosplenic uptake. PMOZ was more effective at decreasing blood clearance rates than PEOZ. The best results, which were quantitatively comparable to the results obtained with the optimized preparations of methoxypolyethylene glycol(PEG)-2000-grafted liposomes, were obtained with formulations containing PMOZ of molecular weight 3260.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§

Zalipsky¹,

Hansen

Oaks³

et al. 1996

Journal of Pharmaceutical Sciences

273

165

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“…This MPS-avoiding effect was reversed by the removal of the sialic acid moiety, demonstrating the important role played by this molecule in MPS-trapping avoidance (Yamauchi et al 1994). …”

Section: Long-circulating Liposomesmentioning

confidence: 95%

New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

2006

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Among several promising new drug-delivery systems, liposomes represent an advanced technology to deliver active molecules to the site of action, and at present several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles (“first-generation liposomes”) to “second-generation liposomes”, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. A significant step in the development of long-circulating liposomes came with inclusion of the synthetic polymer poly-(ethylene glycol) (PEG) in liposome composition. The presence of PEG on the surface of the liposomal carrier has been shown to extend blood-circulation time while reducing mononuclear phagocyte system uptake (stealth liposomes). This technology has resulted in a large number of liposome formulations encapsulating active molecules, with high target efficiency and activity. Further, by synthetic modification of the terminal PEG molecule, stealth liposomes can be actively targeted with monoclonal antibodies or ligands. This review focuses on stealth technology and summarizes pre-clinical and clinical data relating to the principal liposome formulations; it also discusses emerging trends of this promising technology.

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“…Stealth nanocarriers have been obtained using a variety of polysialic acid derivatives, including gangliosides [57–61], ganglioside derivatives, and glycophorin [62–64]. On the contrary, the coating with orosomucoid protein, a sialic acid rich protein, did not yield stealth poly(isobutylcyanoacrylate) nanoparticles.…”

Section: The Opsonisation Processmentioning

confidence: 99%

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Salmaso

Caliceti

2013

Journal of Drug Delivery

279

177

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Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.

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Effects of sialic acid derivative on long circulation time and tumor concentration of liposomes

Cited by 41 publications

References 16 publications

Evaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§

Evaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§

New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

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