2011
DOI: 10.5798/diclemedj.0921.2011.02.0017
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•Effects of sildenafil on isoniazid and streptomycin neurotoxicity in rats

Abstract: Objectives: Neurotoxicity due to isoniazide (INH) and streptomycin has been reported. Experimental studies reported that sildenafil can reduce toxic effects of some drugs. The aim of this study was to investigate the possible toxic effects of long-term streptomycin and INH use and probable protective effects of sildenafil on the rat brain and cerebellum. Materials and methods: In this study, 78 rats were divided into eight groups as follows; control group (n=10), INH group (n=10), streptomycin group (n=10), IN… Show more

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