Effects of Silk Fibroin Moisturizing Cream on Acetone/Ether-Induced Dry Skin Pruritus in Mice

He, Jianming; Tong, Yuling

doi:10.4236/jcdsa.2019.93021

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…SF-based hydrogels are highly flowable, which leads to self-healing and electrically conductive hydrogels [46]. Moreover SF provides a moisturizing effect to the wound site due to the amino acid content present in it [47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Oxidized alginate-gelatin (ADA-GEL)/silk fibroin/Cu-Ag doped mesoporous bioactive glass nanoparticle-based hydrogels for potential wound care treatments

Akhtar,

Nazneen,

Awais

et al. 2024

Biomed. Mater.

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The present work focuses on developing 5% w/v oxidized alginate (alginate di aldehyde, ADA)-7.5% w/v gelatin (GEL) hydrogels incorporating 0.25% w/v silk fibroin (SF) and loaded with 0.3% w/v Cu-Ag doped mesoporous bioactive glass nanoparticles (Cu-Ag MBGNs). Their microstructural, mechanical, and biological properties were characterized in detail. The porous microstructure of the developed ADA-GEL based hydrogels was confirmed by scanning electron microscopy, while the presence of Cu-Ag MBGNs in the synthesized hydrogels was determined using energy dispersive X-ray spectroscopy. The incorporation of 0.3% w/v Cu-Ag MBGNs reduced the mechanical properties of the synthesized hydrogels, as investigated using micro-tensile testing. The synthesized ADA- GEL loaded with 0.25% w/v SF and 0.3% w/v Cu-Ag MBGNs showed a potent antibacterial effect against Escherichia coli and Staphylococcus aureus. Cellular studies using NIH3T3-E1 fibroblast cell lines confirmed that ADA-GEL films incorporated with 0.3% w/v Cu-Ag MBGNs exhibited promising cellular viability as compared to pure ADA-GEL (determined by WST-8 assay). The addition of SF improved the biocompatibility, degradation rate, moisturizing effects, and stretchability of the developed hydrogels, as determined in vitro. Such multimaterial hydrogels can stimulate angiogenesis and exhibit desirable antibacterial properties. Therefore further (in vivo) tests are justified to assess the hydrogels’ potential for wound dressing and skin tissue healing applications.

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