Effects of Silver Sulfadiazine and Adibderm® Herbal Ointments in Treatment of Patients with Second Degree Burns: A Randomized Clinical Trial

Ala, Alireza; Bakhtavar, Hamideh Ebrahimi; Vahdati, Samad Shams; Rahmani, Farzad; Azargoun, Maryam; Bakhtavar, Haniyeh Ebrahimi

doi:10.5812/traumamon.13396

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…In Ala et al's trial, 10 the RO group experienced significantly faster rates of wound healing compared to the control group (7.53 ± 2.28 days vs. 11.83 ± 2.32 days, p < 0.001). The herbal ointment was well tolerated by patients with a significantly greater patient satisfaction score (7.83 ± 1.02 vs. 7.23 ± 1.19, p = 0.041) compared to control.…”

Section: Resultsmentioning

confidence: 89%

“…Ala et al's study 10 consisted of 60 patients presenting to the emergency department with second‐degree burns of 1%–10% in size, aged between 18 and 65 years, with a mean age of 33.7 years. The study employed a randomized controlled trial, with 30 patients in each group.…”

Section: Resultsmentioning

confidence: 99%

“…Valerón‐Almazán et al 9 found lower rates of erythema, dyschromia, and atrophy in postsurgical scars amongst the RO group compared to the control group. In Ala et al's trial, 10 the rosehip extract treatment showed significantly faster wound healing rates in second‐degree burns compared to silver sulfadiazine, a standard burn treatment. These findings demonstrate the potential healing effect of RO.…”

Section: Discussionmentioning

confidence: 99%

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Rosehip extract and wound healing: A review

Belkhelladi,

Bougrine

2023

J of Cosmetic Dermatology

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BackgroundEach year, over 100 million patients are afflicted with new scars from medical procedures worldwide. Natural compounds have shown promise in the treatment of scars and skin disorders. Rosehip oil (RO), produced from the pressed fruit of the rosehip (Rosa canina L.) plant, is used in the pharmaceutical, cosmetic, and food industries. The use of this plant in the treatment of scars has yet to be reviewed.AimsThis review aims to analyze the current findings on the use of RO in the treatment of postsurgical scars.MethodsThis literature search considered published journal articles (clinical trials or literature reviews). Studies were identified by searching electronic databases (PubMed and MEDLINE) and reference lists of respective articles. Additional articles were identified through Google Scholar. Only articles available in English were included in this review.ResultsThere is a scarcity of high‐quality studies assessing the therapeutic potential of RO. From the two human clinical trials using RO, there is some evidence to suggest its potential as an active ingredient in topical formulations for the treatment of wounds. Topical treatments containing RO extract may reduce the size and erythema of postsurgical scars through the polarization of macrophages and the inhibition of inflammatory cytokines.ConclusionsSome evidence suggests that RO may improve postsurgical scars. At present, there is insufficient evidence to recommend the use of RO for the treatment of wounds. Further investigation is required to establish its therapeutic effects on human skin and its potential use as an ingredient in topical formulations.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rosehip extract and wound healing: A review

Belkhelladi,

Bougrine

2023

J of Cosmetic Dermatology

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“…Adibderm ® ointment is a herbal preparation which includes chamomile and rose extracts, ascorbic acid, beeswax, and oleic and linoleic acids. The formulation activity was tested in a randomised clinical trial involving 60 patients with second-degree burns covering 1–10% of the total body surface area, which occurred within 2 h of admission to the emergency room [ 35 ]. Patients were randomly assigned to two groups where patients applied herbal ointment and 1% SSD cream every six hours.…”

Section: Resultsmentioning

confidence: 99%

The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn—A Review

Skowrońska

Bazylko

2023

Pharmaceutics

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Treating burns remains a challenge for modern medicine, especially in developing countries that cannot afford expensive, advanced therapies. This review article summarises clinical and animal model studies of botanical preparations and their mixtures in treating burn wounds and sunburn. Articles available in electronic databases such as PubMed, Scopus, Web of Science, Science Direct and Google Scholar, published in English in 2010–2022, were considered. In the described clinical trials, it was shown that some herbal preparations have better effectiveness in treating burn wounds, including shortening the healing time and reducing inflammation, than the conventional treatment used hitherto. These herbal preparations contained extracts from Albizia julibrissin, Alkanna tinctoria, Aloe vera, Arnebia euchroma, Betula pendula and Betula pubescens, Centella asiatica, Hippophaë rhamnoides, Juglans regia, Lawsonia inermis, and mixtures of Matricaria chamomilla and Rosa canina. Research on animal models shows that many extracts may potentially benefit the treatment of burn wounds and sunburn. Due to the diverse mechanism of action, antibacterial activity, the safety of use and cost-effectiveness, herbal preparations can compete with conventional treatment. The growing interest in alternative medicine and herbal medicine encourages further research. Not only single preparations but also their mixtures should be taken into account because the research conducted so far often suggests a synergistic effect of the ingredients.

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“…�urn ointments are o��ered at di��erent and high prices all over the world, while they do not have the desired e��ect, while the cost o� the Adib herbal burn ointment is much lower than that o� existing products. 22 Since in most parts o� Iran di��erent types o� plants are cultivated and their pharmaceutical processing is possible, in the case of identification of their effects accu� rately, they can be used in the treatment o� various diseases. I� the therapeutic e��ects o� the herbs are determined, the use o� these plants is �ar better than chemical drugs because chemical drugs have a lot o� harm�ul e��ects.…”

Section: Introductionmentioning

confidence: 99%

Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

2019

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Introduction The incidence of gastric ulcers in patients with abdominal stoma is high and affects the quality of patients’ life. Aim To evaluate the effect of Adib herbal ointment containing chamomile rose, black nightshade origin versus Comfeel and Conveen ointments on the skin of abdominal stoma. Material and methods This is a clinical study in which the volunteers were stoma patients. Study group consisted of 52 qualified subjects, 26 were included in the experimental group and 26 in the control group. A 2-part questionnaire was used for the data collection. The 1st part was demographic information. The 2nd part of the data collection was evaluated according to the pressure ulcer scale for healing (PUSH) tool, which used for examining skin ulcers around the stoma. P ≤ 0.05 was considered as a significant. Results and discussion The results of the Mann–Whitney test showed that between the mean score of the total score of the wound before intervention (P = 0.92) and on the 3rd day (P = 0.476), 6th (P = 0.222), 9th (P = 0.11) and 12th (P = 0.418), there was no significant difference between the control and test groups. Also, the Friedman test (intra-group) also showed that between the mean score of the total score of the wound before the intervention and the 3rd, 6th, 9th and 12th days in the control group (P = 0.0001) and in the experimental group (P = 0.0001) There was a significant statistical difference. Conclusions Based on the study, Adib herbal ointment could be recommended for the treatment of stoma to the skin as an herbal product as other common treatments.

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Effects of Silver Sulfadiazine and Adibderm® Herbal Ointments in Treatment of Patients with Second Degree Burns: A Randomized Clinical Trial

Cited by 4 publications

References 13 publications

Rosehip extract and wound healing: A review

Rosehip extract and wound healing: A review

The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn—A Review

Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

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