Effects of silymarin on hepatitis C virus and haem oxygenase‐1 gene expression in human hepatoma cells

Bonifaz, Vania; Shan, Ying; Lambrecht, Richard W.; Donohue, Susan E.; Moschenross, Darcy; Bonkovsky, Herbert L.

doi:10.1111/j.1478-3231.2008.01833.x

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…The decrease in the activity of HO-1 enzymes in the present study could be attributed to the excessive utilization of HO-1 enzyme in inactivating the free radicals generated during the metabolism of B(a)P. Our earlier reports in human erythrocytes show that the major ROS produced during B(a)P metabolism is hydrogen peroxide (Kiruthiga et al, 2007a). Silymarin has been reported to protect the liver by inducing the expression of HO-1 in human hepatoma cells against hepatitis C viral infections induced ROS (Bonifaz et al, 2009). Silibinin also provided DNA protection and reduced oxidative stress in a brain specific area, via the activation of the HO system.…”

mentioning

confidence: 75%

Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes

et al. 2013

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quinone oxidoreductase 1, sulfotransferases), cellular antioxidant enzyme heme oxygenase and total glutathione. The results reveal that silymarin possesses substantial protective effect against B(a)P-induced damages by inhibiting phase I detoxification enzyme CYP1A1 and modulating phase II conjugating enzymes, which were confirmed by histopathological analysis. Overall, the inhibition of CYP1A1 and the modulation of phase II enzymes may provide, in part, the molecular basis for the effect of silymarin against B(a)P.

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confidence: 75%

Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes

et al. 2013

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“…Silymarin can eliminate reactive oxygen species, protect against lipid peroxidation, maintain cell membrane fluidity, protect liver cell membranes and promote liver cell repair and regeneration, which all contribute to combat liver fibrosis (7). The present study aimed to investigate the effects of silymarin on pulmonary vascular dysfunction in a lung I/R injury rat model and assess its underlying molecular mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Jin

Zhao

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Silymarin is a traditional therapeutic used to protect the liver, acting to oppose lipid peroxidation, to enhance liver regeneration and functioning as an antioxidant. However, the effects of silymarin on pulmonary vascular dysfunction have not been investigated. In the present study, the modulatory effects of silymarin on pulmonary vascular dysfunction and the underlying mechanisms behind this were investigated in a lung ischemia-reperfusion (I/R) injury rat model. Male Sprague Dawley rats were randomly divided into 3 groups, including: i) A control group (n=10); ii) an I/R group (n=10); and iii) a silymarin-treated group (n=10). All experimental rats received 250 mg/kg/day of silymarin for 8 days. Silymarin was demonstrated to markedly improve lung I/R-induced pulmonary vascular dysfunction and lung moisture. Following silymarin treatment, inflammation and oxidative stress in the lung I/R-injury rats were demonstrably suppressed. Treatment with silymarin also inhibited the activation of caspase-3 and -9, and hypoxia inducible factor-1α (HIF-1α) and inducible nitric oxide synthase (iNOS) protein expression in the lung I/R-injury rats. Silymarin was concluded to impact upon pulmonary vascular dysfunction through the HIF-1α-iNOS pathway in the lung I/R injury rat model.

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“…Chemopreventive effects of silymarin have been demonstrated in rodents utilizing HCC models by HBV X transgenic mice [153] and N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis in rats [154]. In addition, silymarin has potential to inhibit HCV replication [155,156]. Thus, silymarin may be clinically useful for both eradication of HCV and prevention of HCC, when applied in patients with chronic HCV infection, although prospective, randomized, and controlled trials are necessary to prove it.…”

Section: Silymarinmentioning

confidence: 96%

Chemoprevention against hepatocellular carcinoma

Okano

Fujise

Abe

et al. 2011

Clin J Gastroenterol

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Since the majority of hepatocellular carcinoma (HCC) arises from a background of chronic liver diseases caused by infection with hepatitis C virus (HCV) and hepatitis B virus (HBV), chemoprevention targeting patients at high risk of HCC is feasible. In this review article, we summarize current knowledge of chemoprevention against HCC mostly using phytochemicals which have less toxicity than pharmaceutical agents. We describe in vivo and in vitro evidence and proposed mechanisms of beneficial effects of several compounds on the liver, including acyclic retinoid (ACR), angiotensin-converting enzyme inhibitors (ACEIs), caffeine, capsaicin, cepharanthine (CEP), cinnamaldehyde, curcumin, diallyl sulfide (DAS), eicosapentaenoic acid (EPA), epigallocatechin-3-gallate (EGCG), genistein, lycopene, resveratrol, silymarin, sulforaphane (SFN), and xanthohumol (XN). Because antihepatocarcinogenic effects by these compounds are mostly based on experimental studies, clinical evidence is urgently necessary.

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Effects of silymarin on hepatitis C virus and haem oxygenase‐1 gene expression in human hepatoma cells

Cited by 29 publications

References 38 publications

Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes

Silymarin prevents benzo(a)pyrene-induced toxicity in Wistar rats by modulating xenobiotic-metabolizing enzymes

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Chemoprevention against hepatocellular carcinoma

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