Effects of Silymarin Plus® Versus Antibiotics on Improving Idiopathic Poor Conception and Pregnancy Rates of Mares.

Abstract

Furthermore, Silymarin is a powerful antioxidant through its free radical scavenger ability by decreasing the levels of reduced glutathione so preventing lipid peroxidation (Zhao et al., 2015), and inhibiting enzymes that catalyzing the production of leukotrienes and prostaglandins such as 5lipoxygenase and cyclooxygenase (Valenzuela and Garrido, 1994; Robak and Gryglewski, 1996 and de Groot and Rauen,1998). Also, it is a powerful iron chelator, thereby inhibiting the oxidation of linoleic acid catalyzed by Fe 2+ salts (Ferenci et al., 1989). Silymarin (SIL) protects the normal membrane fluidity by direct interaction with cell membrane components (Muriel and Mourelle, 1990); so it stabilizes cell membranes and makes cells more resisted to osmotic lysis (Ramellini et al., 1974). Moreover, Silymarin had structural similarity with the estrogen so it binds with estrogen receptors and modulates its activity (Khalil, 2002). It also stimulates follicle stimulating hormone (FSH) secretion.