Effects of Simple and Angular Chromones on Tumor Cell Respiration

Araya‐Maturana, Ramiro; Heredia-Moya, Jorge; Donoso‐Tauda, Oscar; Vera, Mario; Toledo, Jorge; Pavani, Mario; Pessoa‐Mahana, Hernán; Weiss-López, Boris; Ferreira, Jorge

doi:10.1177/1934578x0800300409

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…Similar anthraquinone glycosides have also been reported to stimulate cellular proliferation (Choi et al 2001;Lee et al 1997;Yagi et al 2002). It has been postulated that the proliferative effect of anthraquinone glycosides may be due to their high antioxidant activities (Araya-Maturana et al 2008;Gomes et al 2009). …”

Section: Wound Healingmentioning

confidence: 96%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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Plants of the genus Terminalia are amongst the most widely used plants for traditional medicinal purposes worldwide. Many species are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, antiinflammatory and anticancer activities. Wound healing and cardiovascular effects have also been credited to some species. Many Terminalia species have multiple beneficial effects for multiple diseases and ailments. Indeed, the Indian species Terminalia chebula is known as the king of plants in Ayurveda due to its broad range of medicinal uses. However, apart from the reported ethnopharmacological uses of many Terminalia species, surprisingly few studies have rigorously examined this important genus for their medical properties/mechanisms and phytochemistry. This is likely due to the high tannin content common to many Terminalia species and the perception that these tannins may be responsible for much of their beneficial properties. As the complexities of tannins make them poor candidates for drug design, most interest in Terminalia species has been for their pharmacognostic and nutraceutical value and they have often been overlooked as potentials for drug discovery. However, recent reports have identified many other interesting phytochemicals and demonstrated that these may be responsible for several of the reported bioactivities of the Terminalia species used in traditional medicinal systems. The last decade has seen a large increase in the number of studies into the use of Terminalia species as therapeutic agents. Several species used in Ayurvedic medicine (Terminalia arjuna, Terminalia bellerica, Terminalia catappa, T. chebula) in particular have received much recent attention. Similarly, recent reports have also highlighted the medicinal potential of species from Africa, Australia and the Americas. The aim of this report is to summarise the recent research into the medicinal properties, phytochemistry and therapeutic mechanisms of Terminalia species and thus to highlight and direct future areas of research into the medicinal activities of this important genus.

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Section: Wound Healingmentioning

confidence: 96%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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“…These compounds show moderate activity against both cell lines and exhibit very similar activities. In addition, when the formyl group in position 3 is replaced by a hydroxymethyl group, the activity is abolished . (c) From a series of heterocyclic-substituted chromones screened toward a diverse panel of cell lines, 6-chloro-2-(2-quinolyl)chromone (Figure C) emerged as an interesting compound as it display a significant activity toward Sarcoma 180 .…”

Section: Biological Interest Of Simple Chromonesmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

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“…The antioxidant activity of aloesin and various other chromones have also been extensively studied (Gomes et al 2009;Araya-Maturana et al 2008). In contrast, a literature search was unable to find any studies examining the potential prooxidant activity of these compounds.…”

Section: Chromonesmentioning

confidence: 99%

“…Therefore, β -sitosterol and β-sitosterol glucosides have potential applications in wound management in their reduced state. The Aloe chromone aloesin stimulates cellular proliferation (Yagi et al 2002;Choi et al 2001;Lee et al 1997) possibly due to its high antioxidant activity (Gomes et al 2009;Araya-Maturana et al 2008). In contrast, cinnamic acid has been shown to downregulate expression of cell proliferation and anti-apoptotic gene products, although the effects of both high and low concentrations were not examined (Aggarwal et al 2005;Liu et al 1995).…”

Section: Wound Healingmentioning

confidence: 99%

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

2015

Progress in Drug Research

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Effects of Simple and Angular Chromones on Tumor Cell Respiration

Cited by 6 publications

References 39 publications

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

Chromone: A Valid Scaffold in Medicinal Chemistry

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

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