Effects of Simulated Increases in Body Weight on the Growth of Limb Bones in Hypophysectomized Rats

Simon, Margit H.; Holmes, Kate; Olsen, Aart M.

doi:10.1159/000145932

Cited by 3 publications

(2 citation statements)

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“…1984a] suggested that the value of g and the time spent at centrifugation are both significant factors in the effects of simulated increases in body weight on limb bone growth. In our second study using constant centrifugation, male and female hypophysectomized weanling rats were used [Simon et al, 1984b], The results of that study suggested that simulated in creases of body weight within the range of 1.1-2.0 g produced enhanced bone growth, in absolute values. This result was especially significant, considering that the control animals had a statistically significant (p <0.05) greater body weight than any of the experi mental animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of Simulated Increases in Body Weight from Birth on the Growth of Limb Bones in Rats

Simon

Holmes

Olsen³

1985

Cells Tissues Organs

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The purpose of this study was to subject groups of newborn male and female Sprague-Dawley rats each to a specific 10% simulated increase in body weight, to a maximum of a doubling of body weight, to study the effects of quantified, increased, intermittent, compressive forces on limb bone growth. Chronic centrifugation was employed. After 90 days of centrifugation the rats were sacrificed. The humerus, radius, ulna, femur, and tibia were removed from each animal, cleared of all soft tissues, measured and weighed. Tukey’s Studentized multiple range test was performed to identify aggregations (sets) of force groups between which there are significant differences. The data suggest that newborn male and female rats subjected to simulated increases in body weight, within the range used for this study, undergo enhanced general body growth and limb bone growth.

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Section: Introductionmentioning

confidence: 99%

Effects of Simulated Increases in Body Weight from Birth on the Growth of Limb Bones in Rats

Simon

Holmes

Olsen³

1985

Cells Tissues Organs

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“…In a series of recent investigations in this laboratory, groups of rats were subjected to centrifugation within the range 1.1-2.0 g [Simon et al, 1984[Simon et al, . 1985a.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Simulated Increases in Body Weight on the Developing Rat Tibia: A Histologic Study

Simon¹,

Holmes²

1985

Cells Tissues Organs

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Groups of weanling and newborn Sprague-Dawley rats were each subjected to a specific 10% simulated increase in body weight to a maximum of a doubling of body weight, using constant centrifugation, to study the effects of quantified, increased, intermittent, compressive forces on the histomorphology of the proximal tibial epiphysial growth plate. The weanling rats were sacrificed after 30 and 60 days of centrifugation; the newborn rats were sacrificed after 90 days of centrifugation. The results demonstrated no prominent changes in histomorphology, when compared to the controls, in the weanling rats sacrificed at 30 days of centrifugation, or in newborn rats subjected to 90 days of centrifugation; however, a prominent thinning of the growth plates was observed in the weanling rats sacrificed at 60 days of centrifugation.

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Pathomechanics and Classification of Cartilage Lesions, Facilitation of Repair

Walker¹

1998

J Orthop Sports Phys Ther

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Joan M. Walker J oint forces have a high potential to promote degenerative changes in articular cartilage, which initially are subclinical and may not ever produce symptoms. Repetitive impulsive loading of activities throughout the lifespan, but especially in adolescence and young adulthood, has potential consequences in later life. An individual who runs or jogs 20 miles per week over 30 years delivers some 50 million shock waves through his/her body across joint surfaces (65). Workers in industry may spend decades standing and moving on unyielding concrete floors; they also subject joint surfaces to potentially damaging loads. This paper will review the knowledge of why articular cartilage breaks down, pathomechanics, how cartilage lesions are classified i n vitro and i n vivo, and its capacity for repair, with the primary focus on procedures that impact rehabilitation. Other papers in this issue (Cohen et al, Buckwalter, Gillogly et al) should be consulted for detail on the structure and function of articular cartilage, its response to injury, and surgical repair procedures. joint forces have a high potential to promote degenerative changes in articular cartilage. Researchers have not yet developed a material that simulates natural articular cartilage, and replacement procedures have finite lives. In all patients, regardless of diagnostic category, the impact of rehabilitative procedures on the integrity and health of articular cartilage should be a consideration. In this paper, I will review why articular cartilage breaks down, how cartilage lesions are classified in vitro and in vivo, as well as cartilage's capacity for repair and repair enhancement. The primary focus will be on processes and procedures that impact physical therapy. Review sources included common computer-based search instruments and literature in all languages. This research showed that most studies have been conducted on animals, which differ in important respects from humans. Such studies, however, provide guidelines for physical therapists. Unloading and overloading are detrimental to articular cartilage. Research indicates value in controlled, progressive regimes that alternate load and non-load conditions.

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Effects of Simulated Increases in Body Weight on the Growth of Limb Bones in Hypophysectomized Rats

Cited by 3 publications

References 4 publications

Effects of Simulated Increases in Body Weight from Birth on the Growth of Limb Bones in Rats

Effects of Simulated Increases in Body Weight from Birth on the Growth of Limb Bones in Rats

The Effects of Simulated Increases in Body Weight on the Developing Rat Tibia: A Histologic Study

Pathomechanics and Classification of Cartilage Lesions, Facilitation of Repair

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