Effects of simultaneous alcohol and toluene poisoning on the cardiovascular system of rats

Derivation of a chronic oral reference dose for cobalt

“…Pericardial effusion was observed in approximately 50% of the Co-treated animals, and myocardial degeneration without inflammatory cell infiltration was the most commonly reported lesion. Morvai et al (1993) reported that three weeks of exposure to 22.7 mg Co/kg-day (HED = 5.5 mg Co/kg-day) in rats resulted in cardiac damage, presenting as incipient, multifocal myocytolysis, with degeneration of myofibrilles. Following longer-term exposure (two to three months) of rats to 31.7 mg Co/kg-day (HED = 7.6 mg Co/kgday), an increase in heart weight was found (Domingo et al, 1984).…”

Oxidants antioxidants and alcohol implications for skeletal and cardiac muscle

“…In vivo studies examining the short term effects of alcohol have reported decreased myocardial blood flow, increased vascular resistance and ECG disturbances (66). Long-term effects of ischemia on the heart include structural alterations to mitochondria, damaged myofibrils and sarcoplasmic reticulum, and an increase in lipofuscin granules.…”

Report on respiratory symptoms and disease among cemented tungsten carbide workers.

“…Two studies in cemented tungsten carbide workers demonstrated an association between cobalt exposure and poor heart function (decreased left ventricular ejection fraction) [Horowitz et al 1988;D'Adda et al 1994]. Animal studies have confirmed this association [Mohiuddin et al 1970;Speijers et al 1982;Morvai et al 1993]. An allergic skin rash may result from skin exposure to cobalt.…”