Effects Of Simultaneous Prenatal Exposures To Organophosphate And Synthetic Pyrethroid Insecticides On Infant Neurodevelopment At Three Months Of Age

Fluegge, Keith; Nishioka, Marcia; Wilkins, J. R.

doi:10.5281/zenodo.218417

Cited by 13 publications

(3 citation statements)

References 41 publications

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“…Pyrethroid pesticide exposure and ADHD association were reported as having increased and were the cause for hyperactive-impulsive symptoms in children aged 8–11 years old and had deleterious effects on the children's neurodevelopment ( 99 , 100 ). Fluegge et al found that prenatal PYRs exposure exerts heterogeneous effects by class on mental, but not motor, functioning at 3 months of age ( 101 ).…”

Section: Resultsmentioning

confidence: 99%

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

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Pesticides are any mix of ingredients and substances used to eliminate or control unwanted vegetable or animal species recognized as plagues. Its use has been discussed in research due to the scarcity of strong scientific evidence about its health effects. International literature is still insufficient to establish a global recommendation through public policy. This study aims to explore international evidence of the presence of pesticides in urine samples from children and their effects on health through a scoping review based on the methodology described by Arksey and O‘Malley. The number of articles resulting from the keyword combination was 454, and a total of 93 manuscripts were included in the results and 22 were complementary. Keywords included in the search were: urinary, pesticide, children, and childhood. Children are exposed to pesticide residues through a fruit and vegetable intake environment and household insecticide use. Behavioral effects of neural damage, diabetes, obesity, and pulmonary function are health outcomes for children that are commonly studied. Gas and liquid chromatography-tandem mass spectrometry methods are used predominantly for metabolite-pesticide detection in urine samples. Dialkylphosphates (DAP) are common in organophosphate (OP) metabolite studies. First-morning spot samples are recommended to most accurately characterize OP dose in children. International evidence in PubMed supports that organic diets in children are successful interventions that decrease the urinary levels of pesticides. Several urinary pesticide studies were found throughout the world's population. However, there is a knowledge gap that is important to address (public policy), due to farming activities that are predominant in these territories.

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Section: Resultsmentioning

confidence: 99%

Frequency of urinary pesticides in children: a scoping review

Guzman-Torres,

Sandoval-Pinto,

Cremades

et al. 2023

Front. Public Health

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“…On the other hand, 3-PBA is also the most frequently detected biomarker as it covers a large number of pyrethroids pesticides while other measured metabolites are speci c for certain pyrethroids (Lin et al 2021). 3-PBA is a common metabolite of permethrin, cypermethrin, fenvalerate, deltamethrin, cyhalothrin, fenpropathrin, and other commonly used pyrethroid insecticides (Fluegge et al 2016). Notably, 3-PBA has been extensively used as a biomarker re ecting human pyrethroid exposure levels.…”

Section: Measurement Of Pyrethroidmentioning

confidence: 99%

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

Guo

Wang

et al. 2022

Preprint

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Objectives: The evidence interpreting the association between environmental pyrethroid exposure and asthma is limited. The objective of this study was to examine the association between pyrethroid exposure and asthma among U.S. children and adults. Methods: Participants were collected from the National Health and Nutrition Examination Survey (NHANES, 2007-2014), including children and adults. 3-phenoxybenzoic acid (3-PBA) was used as a biomarker for pyrethroid metabolites. Multiple logistic regression models were constructed to estimate the association of urinary 3-PBA with asthma among children and adults and to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Additionally, a restricted cubic spline plot with three knots was applied to assess the potential nonlinear relationship between pyrethroid exposure and asthma.Results: Collectively, 7,776 participants were enrolled, including 2,236 children and 5,540 adults. The weighted prevalence of asthma in children and adults was 12.23% and 8.66% respectively. After adjusting for age, sex, race/ethnicity, poverty income ratio (PIR), body mass index (BMI), serum cotinine, urinary creatinine and family history of asthma, our results indicated that higher levels of 3-PBA was positively related to the risk of asthma among children (OR: 1.395; 95%CI: 0.880, 2.210) and adults (OR: 1.177; 95%CI: 0.778, 1.781). This positive association seemed to be more pronounced among 12-19-years old children and girls. Furthermore, the restricted cubic spline plot showed a linear relationship between levels of 3-PBA and asthma among children and adults (p for nonlinearity was 0.693 and 0.691 respectively).Conclusions: Our study observed a positive association between 3-PBA and asthma among children and adults while this positive association was more pronounced among children. However, we can not role out the possibility that the possible role of other co-occurring pesticides and other chemicals in the observed trends in asthma incidence. Therefore, further studies are needed to evaluate the possible pathogenic role of pyrethroid insecticides in asthma.

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“…These broad-spectrum insecticides pose a major risk to humans especially children and pregnant women [ 22 ]. Where the acute and chronic exposure to OPs and pyrethroids can cause deaths or adverse health effects such as neurological symptoms, respiratory diseases, neurodevelopmental syndrome, hormonal and reproductive disturbance, chronic diseases, and cancer risks [ 23 – 24 ]. This risk has necessitated periodic and comprehensive monitoring of insecticide resistance in insect vectors, including Cx.…”

Section: Introductionmentioning

confidence: 99%

First comprehensive report of the resistance of Culex quinquefasciatus Say (Diptera: Culicidae) to commonly used insecticides in Riyadh, Saudi Arabia

Hafez

2023

Heliyon

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Effects Of Simultaneous Prenatal Exposures To Organophosphate And Synthetic Pyrethroid Insecticides On Infant Neurodevelopment At Three Months Of Age

Cited by 13 publications

References 41 publications

Frequency of urinary pesticides in children: a scoping review

Frequency of urinary pesticides in children: a scoping review

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

First comprehensive report of the resistance of Culex quinquefasciatus Say (Diptera: Culicidae) to commonly used insecticides in Riyadh, Saudi Arabia

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