Effects of Simvastatin and Metformin on Polycystic Ovary Syndrome after Six Months of Treatment

Banaszewska, Beata; Pawełczyk, Leszek; Spaczyński, Robert; Dulęba, Antoni J.

doi:10.1210/jc.2011-0501

Cited by 90 publications

(64 citation statements)

References 47 publications

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“…Metformin indicated considerably larger reduction in comparison with two other treatments. As the results imply, Metformin will be more useful in the patients with high FBS, whereas other studies did not show significant change in fasting glucose in the metformin[113] and simvastatin groups. [1] Therefore, the effect of metformin on FBS needs more research.…”

Section: Discussionmentioning

confidence: 85%

“…The effect of Simvastatin on TG reduction was significantly larger than two other treatments, however, in some studies metformin showed a significant effect on TG, whereas simvastanin did not. [1] In other study, TG decreased significant decrease in statin plus OC compared with OCP alone. [4] Therefore, simvastatin may be an appropriate treatment for the patients with high levels of TG.…”

Section: Discussionmentioning

confidence: 92%

“…[119] Depending on the definition, it can affect up to 25% of women in reproductive ages. [7] There are different treatments for PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…This may affect upto 10% of women of reproductive ages in different countries,[123] although the large number of studies in different countries has estimated its prevalence at 5-7% in diverse population,[456] depending on the definition, it can affect up to 25% of women of reproductive age. [7]…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome

et al. 2016

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Background:Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of reproductive ages. It is associated with a range of disorders, such as dyslipidemia, hypertension, insulin resistance (IR), compensatory hyperinsulinemia, gestational, and type 2 diabetes, and increased risk of cardiovascular morbidity. There are different treatments available for PCOS. The purpose of this study was to determine and compare the effects of metformin, flutamide plus oral contraceptives (OCs), and simvastatin on the metabolic consequences of PCOS.Materials and Methods:This study was a single-blind clinical trial. The subjects were selected from a group of patient with PCOS and metabolic syndrome, who were referred to the midwifery clinic of Al-Zahra Hospital and Beheshti Hospital, Isfahan, Iran. A total of 111 subjects were randomly assigned to three groups: metformin, flutamide plus OCs, and simvastatin groups. The measurements were performed at baseline and after 6 months of therapy. Paired t-test, analysis of variance (ANOVA), and chi-square test were applied in this study.Results:A total of 102 subjects were analyzed in this study, 34 subjects were allotted in each group. The prevalence of IR was statistically different between three groups (P-value = 0.001). After a 6-month course, metformin showed larger reduction in fasting blood sugar (FBS) level (P-value < 0.001). However, except for metformin, two other treatments reduced C-reactive protein (CRP) level significantly (both P-values < 0.001). The level of triglycerides (TGs) decreased considerably in all groups (all P-values < 0.001). Both metformin and simvastatin decreased BMI significantly (both P-values < 0.001). None of the treatments changed high-density lipoprotein (HDL) level (all P-values > 0.05).Conclusion:Metformin performed better in FBS reduction. Simvastatin had better performance in terms of reducing TG level and waist circumference.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 92%

“…[119] Depending on the definition, it can affect up to 25% of women in reproductive ages. [7] There are different treatments for PCOS.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome

et al. 2016

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“…The use of statins in PCOS might improve not only lipids but also hyperandrogenemia (87). Interestingly, it has been shown in a randomized controlled trial (RCT) in 40 PCOS patients that 12-week treatment with atorvastatin at a dose of 20 mg daily resulted in a significant increase in serum 25(OH)D concentrations that was independent of the lipid-lowering effect of atorvastatin (88).…”

Section: Womenmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Lerchbaum

Obermayer-Pietsch

2012

European Journal of Endocrinology

343

252

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Background: Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. Aim: The aim of this review was to assess the studies that evaluated the relationship between vitamin D and fertility in women and men as well as in animals. Methods: We performed a systematic literature search in Pubmed for relevant English language publications published until October 2011. Results and discussion: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vdr knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. In men, vitamin D is positively associated with semen quality and androgen status. Moreover, vitamin D treatment might increase testosterone levels. Testiculopathic men show low CYP21R expression, low 25(OH)D levels, and osteoporosis despite normal testosterone levels.

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Statins for women with polycystic ovary syndrome not actively trying to conceive

Xiong

Fraison

Kolibianaki

et al. 2023

Cochrane Database of Systematic Reviews

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Effects of Simvastatin and Metformin on Polycystic Ovary Syndrome after Six Months of Treatment

Abstract: Long-term treatment with simvastatin was superior to metformin. Improvement of ovarian hyperandrogenism continued throughout the duration of the study.

Cited by 90 publications

References 47 publications

Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome

Comparison of the effects of metformin, flutamide plus oral contraceptives, and simvastatin on the metabolic consequences of polycystic ovary syndrome

MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review

Statins for women with polycystic ovary syndrome not actively trying to conceive

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