Effects of single dose irradiation on pancreatic beta-cell function

Sarri, Y; Conill, Carles; Verger, E.; Tomás, C. Luzuriaga; Gomis, Ramón

doi:10.1016/0167-8140(91)90011-5

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…Data about radiation related pancreatic tissue toxicity in the literature are based mainly on animal studies or abdominal irradiation for pediatric solid tumors or total body irradiation (TBI) for bone marrow transplantation in hematologic malignancies [5][6][7][8][9][13][14][15][16][17][18]. Acinar cells of the pancreas are much more sensitive to radiation damage than islet cells and the pathophysiology of radiation damage is mainly due to chronic vascular injury with eventual fibrosis and atrophy of the gland [5][6][7][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Gemici

Sargın

Uygur-Bayramiçli

et al. 2013

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 99%

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Gemici

Sargın

Uygur-Bayramiçli

et al. 2013

Radiotherapy and Oncology

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“…Radiation could cause pancreatic insufficiency as evidence by degranulation, vacuolization, mitochondrial destruction, and impaired insulin secretion by the islet cells after exposure to radiation in animal studies. (27, 28) The relation between osteonecrosis and TBI has been reported. (29, 30) Osteonecrosis is likely due to vascular damage secondary to TBI.…”

Section: Discussionmentioning

confidence: 99%

Burden of Morbidity in 10+ Year Survivors of Hematopoietic Cell Transplantation: Report from the Bone Marrow Transplantation Survivor Study

Sun

Kersey

Francisco

et al. 2013

Biology of Blood and Marrow Transplantation

109

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Long-term morbidity after hematopoietic cell transplantation (HCT) is unknown. The risk of physical and psychological health in 324 patients who had survived 10 or more years after HCT, and a sibling comparison group (n=309) was evaluated. Using the CTCAE v3.0, the 15-year cumulative incidence of severe/life-threatening/fatal conditions was 41% (95%CI, 34–48%). HCT survivors were 5.7 times as likely to develop a severe/life-threatening condition (p<0.001), and 2.7 times as likely to report somatic distress (p<0.001) compared with siblings. Compared with allogeneic HCT recipients with no chronic GvHD, those with active chronic GvHD were at a 1.8-fold higher risk of severe/life-threatening health conditions (p=0.006), and 4.5-fold higher risk of somatic distress (p=0.04); allogeneic HCT recipients with resolved chronic GvHD were not at increased risk of morbidity compared with those with no chronic GvHD. Only 27% of the HCT survivors returned to the transplant center for their cancer-related care. The burden of long-term physical and emotional morbidity borne by survivors remains substantial, even beyond 10 years after HCT; however, specialized healthcare is underutilized. Patients, families and healthcare providers need to be made aware of the high burden, such that they can plan for post-HCT care, even many years after HCT.

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“…Small animal studies suggest that following radiation, the pancreatic islet cells show evidence of degranulation, vacuolization, mitochondrial destruction, and impaired insulin secretion. 29,30 Pancreatic insufficiency, relative or absolute, may result following irradiation. Of note, however, most survivors in our study who had DM following abdominal irradiation were either on oral medication or combination therapy, suggesting that if they have β-cell dysfunction, it is not absolute.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus in Long-term Survivors of Childhood Cancer

Meacham¹,

Sklar²,

Li³

et al. 2009

Arch Intern Med

286

124

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Background Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, this study aimed to compare the prevalence of diabetes mellitus (DM) in childhood cancer survivors and their siblings. Methods Participants included 8599 survivors in the Childhood Cancer Survivor Study (CCSS), a retrospectively ascertained North American cohort of long-term survivors who were diagnosed 1970–1986, and 2936 randomly selected siblings of CCSS survivors. The main outcome was self-reported DM. Results Survivors and siblings had mean ages of 31.5 years (range, 17.0–54.1) and 33.4 years (range, 9.6–58.4), respectively. DM was reported in 2.5% of survivors and 1.7% of siblings. Adjusting for body mass index (BMI), age, sex, race/ethnicity, household income, and insurance, survivors were 1.8 times more likely to report DM (95% confidence interval [CI], 1.3–2.5; P<0.001) than siblings, with survivors who received total body irradiation (odds ratio [OR], 12.6; 95% CI, 6.2–25.3; P<0.001), abdominal irradiation (OR, 3.4; 95% CI, 2.3–5.0; P<0.001) and cranial irradiation (OR, 1.6; 95% CI 1.0–2.3; P=0.03) at increased risk. In adjusted models, increased risk of DM was associated with: total body irradiation (OR 7.2; 95% CI, 3.4–15.0; P<0.001); abdominal irradiation (OR 2.7; 95% CI, 1.9–3.8; P<0.001); alkylating agents (OR 1.7; 95% CI, 1.2–2.3; P<0.01); and younger age at diagnosis (0–4 years; OR 2.4; 95% CI 1.3–4.6; P<0.01). Conclusions Childhood cancer survivors treated with total body or abdominal irradiation have an increased risk of diabetes that appears unrelated to BMI or physical inactivity.

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Effects of single dose irradiation on pancreatic beta-cell function

Cited by 15 publications

References 7 publications

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Burden of Morbidity in 10+ Year Survivors of Hematopoietic Cell Transplantation: Report from the Bone Marrow Transplantation Survivor Study

Diabetes Mellitus in Long-term Survivors of Childhood Cancer

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