Effects of Single or Repeated Administrations of Methamphetamine on Immune Response in Mice

Saito, Masayoshi; Terada, Masaru; Kawata, Tetsuya; Ito, Hisao; Shigematsu, Naoyuki; Kromkhun, Pudcharaporn; Yokosuka, Makoto; Saitô, Tôru

doi:10.1538/expanim.57.35

Cited by 33 publications

(31 citation statements)

References 30 publications

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“…Additionally, increased quantities of pro-inflammatory cytokines, IFN-γ, TNF-α, IL-6, and IL-12, correlate with a sustained cellular inflammatory response and tissue injury. Similar to previous studies, METH reduced the distribution of splenic T lymphocyte and produces immunosuppression (Saito, Terada et al 2008; Martinez, Mihu et al 2009), which could also contribute to the higher rate of infections in METH users. In this regard, METH induces cell death of the splenic lymphocytes via apoptosis (Iwasa, Maeno et al 1996).…”

Section: Discussionsupporting

confidence: 86%

Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues

et al. 2013

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Methamphetamine (METH) is a potent and highly addictive central nervous system (CNS) stimulant. Additionally, METH adversely impacts immunological responses, which might contribute to the higher rate and more rapid progression of certain infections in drug abusers. However no studies have shown the impact of METH on inflammation within specific organs, cellular participation and cytokine production. Using a murine model of METH administration, we demonstrated that METH modifies, with variable degrees, leukocyte recruitment and alters cellular mediators in the lungs, liver, spleen and kidneys of mice. Our findings demonstrate the pleotropic effects of METH on the immune response within diverse tissues. These alterations have profound implications on tissue homeostasis and the capacity of the host to respond to diverse insults, including invading pathogens.

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Section: Discussionsupporting

confidence: 86%

Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues

et al. 2013

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“…Prenatal METH exposure results in sex-dependent deficits in hippocampal-dependent memory tasks [11]. Sex differences have also been observed in METH-induced immune responses [12] and hypothalamic-pituitary-adrenal (HPA) axis activation [13]. Yet, the influence of sex on acute METH-induced hyperactivity in mice has not been thoroughly examined.…”

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confidence: 99%

Sex differences in the acute locomotor response to methamphetamine in BALB/c mice

Ohia-Nwoko

Haile

Kosten

2017

Behavioural Brain Research

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Women use methamphetamine more frequently than men and are more vulnerable to its negative psychological effects. Rodent models have been an essential tool for evaluating the sex-dependent effects of psychostimulants; however, evidence of sex differences in the behavioral responses to methamphetamine in mice is lacking. In the present study, we investigated acute methamphetamine-induced (1 mg/kg and 4 mg/kg) locomotor activation in female and male BALB/c mice. We also evaluated whether basal locomotor activity was associated with the methamphetamine-induced locomotor response. The results indicated that female BALB/c mice displayed enhanced methamphetamine-induced locomotor activity compared to males, while basal locomotor activity was positively correlated with methamphetamine-induced activity in males, but not females. This study is the first to show sex-dependent locomotor effects of methamphetamine in BALB/c mice. Our observations emphasize the importance of considering sex when assessing behavioral responses to methamphetamine.

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“…Previous studies have demonstrated additional immunosuppressive effects of methamphetamine, including decreased proliferation, decreased NK activity by splenic lymphocytes of mice (Saito et al, 2008; Yu et al, 2002) and increased T cell dysfunction in human cells after passive methamphetamine treatment (Potula et al, 2010). However, methamphetamine effects on circulating levels of cytokines have been more difficult to demonstrate (Buchanan et al, 2010; Loftis et al, 2011; Valencia et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies involve acute, passive (experimenter administered) treatments with high doses of methamphetamine and these protocols show increased production of serum IFN-γ and TNF-α impaired proliferation and function in splenocytes, and enhanced cytokine levels in the striatum and other brain regions of mice (Flora et al, 2002; Goncalves et al, 2008; Saito et al, 2008; Valencia et al, 2012; Yu et al, 2002). However, these immunosuppressive effects of methamphetamine have not been investigated using contingent, self-administration protocols.…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse

Mata

Napier

Graves

et al. 2015

European Journal of Pharmacology

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The reason co-morbid methamphetamine use and HIV infection lead to more rapid progression to AIDS is unclear. We used a model of methamphetamine self-administration to measure the effect of methamphetamine on the systemic immune system to better understand the comorbidity of methamphetamine and HIV. Catheters were implanted into the jugular veins of male, Sprague Dawley rats so they could self-administer methamphetamine (n = 18) or be given saline (control; n = 16) for 14 days. One day after the last self-administration session, blood and spleens were collected. We measured serum levels of pro-inflammatory cytokines, intracellular IFN-γand TNF-α, and frequencies of CD4+, CD8+, CD200+ and CD11b/c+ lymphocytes in the spleen. Rats that self-administer methamphetamine had a lower frequency of CD4+ T cells, but more of these cells produced IFN-γ. Methamphetamine did not alter the frequency of TNF-α-producing CD4+ T cells. Methamphetamine using rats had a higher frequency of CD8+ T cells, but fewer of them produced TNF-α. CD11b/c and CD200 expression were unchanged. Serum cytokine levels of IFN-γ, TNF-α and IL-6 in methamphetamine rats were unchanged. Methamphetamine lifetime dose inversely correlated with serum TNF-α levels. Or data suggest that methamphetamine abuse may exacerbate HIV disease progression by activating CD4 T cells, making them more susceptible to HIV infection, and contributing to their premature demise. Methamphetamine may also increase susceptibility to HIV infection, explaining why African American men who have sex with men (MSM) and frequently use methamphetamine are at the highest risk of HIV infection.

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Effects of Single or Repeated Administrations of Methamphetamine on Immune Response in Mice

Abstract: The present study aimed to clarify the connection between immune responses and the administration frequency of methamphetamine (MAP) in

Cited by 33 publications

References 30 publications

Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues

Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues

Sex differences in the acute locomotor response to methamphetamine in BALB/c mice

Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse

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