Effects of Singlet Oxygen on the Biological Activity of DNA and Its Involvement in Single Strand-Break Formation

Wefers, Heribert; Mascio, Paolo Di; Do-Thi, Hong-Phuc; Schulte‐Frohlinde, D.; Sies, Helmut

doi:10.1007/978-1-4684-5568-7_73

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Polyuridylic Acid and Polycytidylic Acid1

Introduction1

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1990

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“…To explain this phenomenon it was proposed that in the latter case, the radical cation of the uracil moiety reacts rapidly with water thereby forming predominantly OH-adduct radicals of the base (von Sonntag, 1987;SchulteFrohlinde, 1989). This was demonstrated experimentally by Schulte-Frohlinde and Hildenbrand (1989).…”

Section: Polyuridylic Acid and Polycytidylic Acidmentioning

confidence: 99%

“…One of the motivations behind these photoionization studies is to gain a better understanding of the direct effects of high-energy radiation on DNA which leads to strand breaks (SchulteFrohlinde, 1986a(SchulteFrohlinde, , 1986b(SchulteFrohlinde, , 1989. The radiationinduced double-strand breaks are the most serious damage to DNA in cells which, if unrepaired, lead to cell transformation, mutation and cell death (Ward, 1975(Ward, , 1990Schulte-Frohlinde, 1987a, 1987b.…”

Section: Introductionmentioning

confidence: 99%

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